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Apple Valley, CA Office Spaces for Lease

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37 properties
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Remodeled Medical Office
Updated: Jul 6
Remodeled Medical Office

18387 US Highway 18, Apple Valley, CA 92307

$2,995/Mo
Three private medical exam rooms
Two lobby or waiting areas within the clinic layout
Administrative offices plus a private physician office with bathroom
Client parking at the front and employee parking at the rear
US Highway 18 frontage at Corwin Road
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Medical Office Near Hospital
Updated: Jun 16
Medical Office Near Hospital

15995 Tuscola, Apple Valley, CA 92307

Contact for pricing
975 sq. ft. medical office space
Near St Mary's Hospital
Just off HWY 18 in Apple Valley
Shared 20 parking spaces in front
2 handicap spaces
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Newer Office Space with Solar
Newer Office Space with Solar

16098 Kamana Road, Apple Valley, CA 92307

Contact for pricing

Office space in a 2014 building with central air and mountain views.

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Office Unit with New Flooring
Office Unit with New Flooring

18270 Siskiyou Rd Unit 2, Apple Valley, CA 92307

$1,707/Mo
3,392 sqft

Unoccupied second-floor office suite with an open layout, private restroom, and professional zoning.

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High-Visibility Storefront Space
High-Visibility Storefront Space

21065 Bear Valley, Apple Valley, CA 92308

$1,000/Mo
6,000 sqft

Highly visible storefront space suited for office or retail, with low walkability and minimal transit.

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Medical Office Suite with Exam Rooms
Medical Office Suite with Exam Rooms

110-18092 Wika Rd, Apple Valley, CA 92307

$1,960/Mo
1,400 sqft

Suite 110 features exam rooms, a spacious waiting area with reception window, and an administrative workspace with cabinetry.

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Office Suite with Elevator Access
Office Suite with Elevator Access

203-16070 Tuscola Rd, Apple Valley, CA 92307

$2,028/Mo
1,193 sqft

Second-floor suite features an open office plan, private restroom, and two access doors via elevator and stairs.

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Turnkey Medical Clinic Office
Turnkey Medical Clinic Office

18387 US Highway 18, Apple Valley, CA 92307

$2,995/Mo

Completely remodeled medical clinic with exam rooms, dedicated client and employee parking, and multiple private offices.

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Retail or Office Suite
Retail or Office Suite

13605 Central Rd, Apple Valley, CA 92308

Contact for pricing
11,230 sqft

Retail/office space offering approximately 1,497 sq ft and parking, near Hwy 18 for strong neighborhood accessibility.

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Medical Office Suite with Pool Area
Medical Office Suite with Pool Area

D-18145 Us Highway 18, Apple Valley, CA 92307

Contact for pricing
4,900 sqft

Suite D offers a flexible medical layout with multiple offices, exam rooms, restrooms, and an indoor pool area.

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Office Unit with Private Patio
Office Unit with Private Patio

16191 Kamana Rd Unit 203, Apple Valley, CA 92307

Contact for pricing
8,701 sqft

Professional second-floor workspace with private outdoor area, multiple enclosed offices, and convenient Highway 18 access.

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Two-Story Multi-Tenant Shopping Center
Two-Story Multi-Tenant Shopping Center

17993 Us Hwy 18 Unit 107, Apple Valley, CA 92307

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13,622 sqft

Available upstairs suite includes a reception area, private executive office, and open bullpen workspace.

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Medical Office Suite with Pool Area
Medical Office Suite with Pool Area

18145 US Hwy 18 Suite D, Apple Valley, CA 92307

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4,900 sqft

Suite D offers a large, flexible medical office layout with a dedicated waiting foyer and an indoor pool area requiring repairs.

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Office Suite with Hardwood Floors
Office Suite with Hardwood Floors

20600 Us Highway 18 Unit 194, Apple Valley, CA 92307

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64,784 sqft

Open-plan commercial suite with a private restroom and finished hardwood flooring.

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Apple Valley Professional/Medical Space
Apple Valley Professional/Medical Space

16070 Tuscola Rd 202, Apple Valley, CA 92307

$1,654/Mo
0.36 AC lot

Upstairs suite in prime location near Highway 18 and hospital.

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Medical Office Suite with Highway Frontage
Medical Office Suite with Highway Frontage

19195 Us Highway 18 Unit 106, Apple Valley, CA 92307

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16,340 sqft

First-floor suite offers a reception area, private office, open workspace, support rooms, and rear parking-lot access.

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Two-Story Multi-Tenant Retail Space
Two-Story Multi-Tenant Retail Space

2-17993 Us Hwy 18, Apple Valley, CA 92307

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1,122 sqft

Open front space combines with private rear rooms and dedicated shelving for on-site storage.

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First-Floor Medical Office Suite
First-Floor Medical Office Suite

106-19195 Us Highway 18, Apple Valley, CA 92307

Contact for pricing
2,000 sqft

Highway frontage, monument signage, and a flexible interior layout support a range of medical office functions.

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Apple Valley Office Space Available
Apple Valley Office Space Available

15099 Kamana Rd, Apple Valley, CA 92307

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4,685 sqft

Two-story office building near St. Mary’s Medical Center.

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Office Suite in Historic Inn
Office Suite in Historic Inn

102-20600 Us Highway 18, Apple Valley, CA 92307

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600 sqft

Its adaptable interior is suited to office or retail operations.

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Office/Retail Suite with In-Suite Restroom
Office/Retail Suite with In-Suite Restroom

175-20600 Us Highway 18, Apple Valley, CA 92307

Contact for pricing
700 sqft

Versatile office/retail suite with multiple rooms and an in-suite restroom inside the Apple Valley Inn.

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Medical Office Space with Veranda
Medical Office Space with Veranda

15099 Kamana Rd, Apple Valley, CA 92307

Contact for pricing
4,685 sqft 1.03 AC lot

Second floor medical office space with a large private veranda.

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Medical Office Suite with OR
Medical Office Suite with OR

18056 Wika Road D, Apple Valley, CA 92307

$2,958/Mo

Former surgical-center suite includes patient intake, examination, and procedure areas, with ambulance gurney access.

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Medical Office Space
Medical Office Space

202-15995 Tuscola Rd, Apple Valley, CA 92307

Contact for pricing
975 sqft

Medical office space with 20 shared front parking spaces and 12 rear spaces, near St Mary's Hospital.

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Apple Valley, CA Office Spaces Lease Rates & Market Statistics

Browse 37 Office Spaces for lease in Apple Valley, CA on Realmo, a commercial real estate marketplace serving the Apple Valley area. The current inventory totals 242,326 square feet of properties — an average of ~6,550 SF per listing.

Asking lease rates for Office Spaces in Apple Valley start at $2.00 SF/Yr, average $13.07 SF/Yr, and reach $20.40 SF/Yr at the top of the market. That's a 10x spread between entry-level and premium space, making side-by-side comparison of asking rents and lease terms essential. At $13.07 SF/Yr, the local average runs 47% below California's state average of $24.67 SF/Yr.

Apple Valley accounts for 7% of the 517 office spaces currently available across San Bernardino County, where nearby markets include Ontario and Rancho Cucamonga. By space type, the market includes 23 office units and 18 medical office space listings — office units typically offer the lowest entry point, while medical office space commands the highest rates.

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