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    Hesperia, CA Medical Office Space for Lease

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    Move-In Ready Office Suite
    Updated: Jul 9
    Move-In Ready Office Suite

    16455 Main Street, Hesperia, CA 92345

    Contact for pricing
    Move‑in ready Suite 15 in The Hesperia Center, built in 1991
    +/-1,500 SF available April 2026 with a front reception, two private offices, two additional rooms, and a large open workspace
    Suite includes 1 restroom
    Located on Main Street with immediate access to Hesperia Road and the High Desert trade area
    Abundant on‑site parking and signage exposure along a high‑traffic commercial corridor
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    Medical Office Suite with Three Offices
    Updated: Jul 4
    Medical Office Suite with Three Offices

    17151 Main St B, Hesperia, CA 92345

    $2,050/Mo
    1,500 sqft
    Suite B available for lease in a multi‑tenant commercial building built in 1981
    Suite B includes 3 offices built out plus a waiting room
    Rentable area +/-1,500 SF and usable area +/-1,275 SF for Suite B
    Base rent is $1,650/month plus NNN of $400/month ($2,050/month total), plus utilities
    Street frontage with pylon signage and high traffic count
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    Medical Office Suite with Waiting Room
    Medical Office Suite with Waiting Room

    B-17151 Main St, Hesperia, CA 92345

    $2,050/Mo
    1,500 sqft

    Multi-tenant building offers a built-out suite with three offices and a waiting room.

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    Turn-Key Dental Office Suites
    Turn-Key Dental Office Suites

    18361 Bear Valley Rd 2&3, Hesperia, CA 92345

    $3,200/Mo
    1,600 sqft

    Turn-key dental office suites available in a multi-tenant plaza with street visibility and pylon signage.

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    Freestanding Office Building
    Freestanding Office Building

    16303 Main, Hesperia, CA 92345

    $2,819/Mo

    Freestanding commercial building with a flexible interior plan, prominent monument/pylon signage, and ample on-site parking.

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    Medical Office Space Available
    Medical Office Space Available

    17450 Main St F, Hesperia, CA 92345

    Contact for pricing
    1,438 sqft

    Medical office space for rent in Hesperia, CA.

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    Medical Office Space Available
    Medical Office Space Available

    15462 Main St, Hesperia, CA 92345

    $17.76 SF/Yr
    678 sqft

    Private office space in medical professional building for rent.

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    Medical Office Space Available
    Medical Office Space Available

    15462 Main St C, Hesperia, CA 92345

    Contact for pricing
    678 sqft

    Private office space in medical building with exterior access.

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    Medical Office Suite with Private Entrance
    Medical Office Suite with Private Entrance

    D-17450 Main St, Hesperia, CA 92345

    $2,448/Mo

    Medical office suite with exam rooms, kitchenette, and dedicated front and rear entry for staff and patient access.

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    Medical Office Space Available
    Medical Office Space Available

    15462 Main St C, Hesperia, CA 92345

    Contact for pricing

    Private office space in medical building with exterior access.

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    Based on your search, we've compiled 21 Potential Opportunities for your consideration. Besides 10 Active listings in Hesperia, CA, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 3 Properties for Sales.

    Medical Office Space for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Premium Office Space Available
    Premium Office Space Available

    19341 Bear Valley Rd, Apple Valley, CA 92308

    $24 SF/Yr
    3,000 sqft

    Nearly 3,000 sq. ft. office space in Apple Valley.

    View details
    Medical Office Space
    Medical Office Space

    202-15995 Tuscola Rd, Apple Valley, CA 92307

    Contact for pricing
    975 sqft

    Medical office space with 20 shared front parking spaces and 12 rear spaces, near St Mary's Hospital.

    View details
    Renovated Medical Office Suite
    Renovated Medical Office Suite

    15980 Bear Valley Rd, Victorville, CA 92395

    Contact for pricing
    4,330 sqft

    Renovated medical office space with major system upgrades completed in 2017.

    View details
    Freestanding Medical Office Building
    Freestanding Medical Office Building

    Victorville, CA 92395

    Contact for pricing

    Freestanding medical office built in 1999 and renovated in 2017, located on Bear Valley Road with access to I-15.

    View details

    Similar Spaces for Sale in Hesperia, CA

    Consider Similar Space for Sale. We found 3 Spaces matching your search parameters.

    Renovated Multi-Suite Office/Retail Building
    Renovated Multi-Suite Office/Retail Building

    9179 G Avenue, Hesperia, CA 92345

    $875,000
    3,200 sqft

    Renovated building with flexible multi-suite layout, strong visibility, and an ADA restroom for medical, retail, or service uses.

    View details
    Freestanding Office Building with Visibility
    Freestanding Office Building with Visibility

    16229 Bear Vly, Hesperia, CA 92345

    $725,000
    2,541 sqft

    Freestanding office building on a high-traffic corridor with General Commercial (C2) zoning for office and retail uses.

    View details
    Built-Out Office Suite with Waiting Room
    Built-Out Office Suite with Waiting Room

    17151 Main Street Unit B, Hesperia, CA 92345

    Contact for pricing
    6,000 sqft

    Suite B offers three built-out offices and a waiting room in a multi-tenant commercial building on Main Street.

    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Commercial Land for Long-Term Lease
    Commercial Land for Long-Term Lease

    5538 E Paisano Drive, El Paso, TX 79905

    $5,950/Mo

    Lease a C4-zoned lot with easy interstate access, suited for a range of business and professional uses.

    View details
    Office Development Land For Lease
    Office Development Land For Lease

    1323 Strawfloor Drive, Jonesboro, AR 72401

    Contact for pricing
    4,000 sqft

    2.43 acres for office development with build-to-suit opportunity.

    View details
    Corner Lot on Highway 72
    Corner Lot on Highway 72

    30472 Highway 72, Madison, AL 35756

    $5,000/Mo
    1,875 sqft

    1.7 acre corner lot zoned for commercial, medical, residential.

    View details
    Prime Lexington Outlot Opportunity
    Prime Lexington Outlot Opportunity

    3330 Partner Place, Lexington, KY 40503

    Contact for pricing

    Outlot for ground lease or build-to-suit in South Lexington.

    View details

    Hesperia, CA Medical Office Space Market Trends and Statistics

    Explore Medical Office Space leasing options in Hesperia, CA with 10 listings featured on our commercial real estate exchange. The current inventory includes 5,278 square feet of properties with an estimated lease value of $74.56 SF/Yr.

    Estimated lease rates for Medical Office Space in Hesperia, CA begin at $16.40 SF/Yr, with an average of $18.64 SF/Yr and extend to $24 SF/Yr.
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