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    Hesperia, CA Medical Office Space for Lease

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    12 properties
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    Medical Office Suite with Three Offices
    Updated: Jul 4
    Medical Office Suite with Three Offices

    17151 Main Street B, Hesperia, CA 92345

    $2,050/Mo
    6,000 sqft
    Suite B available for lease in a multi‑tenant commercial building built in 1981
    Suite B includes 3 offices built out plus a waiting room
    Rentable area +/-1,500 SF and usable area +/-1,275 SF for Suite B
    Base rent is $1,650/month plus NNN of $400/month ($2,050/month total), plus utilities
    Street frontage with pylon signage and high traffic count
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    Turn-Key Dental Office Suites
    Updated: Jul 8
    Turn-Key Dental Office Suites

    18361 Bear Valley Road 2&3, Hesperia, CA 92345

    $3,200/Mo
    10,246 sqft
    Turn‑key dental office space in D & J multi‑tenant plaza (Year built 1984).
    Suites 2 & 3 total 1,600 SF.
    Asking rent $3,200/month includes NNN + utilities.
    Located across from Victor Valley College with signalized intersection access.
    Street visibility with pylon signage and high traffic count.
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    Medical Office Suite with Waiting Room
    Medical Office Suite with Waiting Room

    B-17151 Main St, Hesperia, CA 92345

    $2,050/Mo
    1,500 sqft

    Multi-tenant building offers a built-out suite with three offices and a waiting room.

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    Medical Office Space Available
    Medical Office Space Available

    17450 Main St H, Hesperia, CA 92345

    $3,700/Mo
    1,438 sqft

    Medical office space for rent in Hesperia, CA.

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    Freestanding Office Building
    Freestanding Office Building

    16303 Main, Hesperia, CA 92345

    $2,819/Mo

    Freestanding commercial building with a flexible interior plan, prominent monument/pylon signage, and ample on-site parking.

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    Medical Office Suite with Exam Rooms
    Medical Office Suite with Exam Rooms

    F-17450 Main Street, Hesperia, CA 92345

    Contact for pricing
    1,438 sqft

    Single-story center offers patient and staff entrances, three bathrooms, kitchenette, and private office space.

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    Medical Office Suite with Exam Rooms
    Medical Office Suite with Exam Rooms

    H-17450 Main St, Hesperia, CA 92345

    $3,700/Mo
    2,177 sqft

    Configured for patient-facing operations with reception, treatment space, private offices, and four restrooms.

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    Medical Office Suite with Exam Rooms
    Medical Office Suite with Exam Rooms

    17450 Main Street H, Hesperia, CA 92345

    $3,700/Mo
    2,177 sqft

    Single-story professional-center space includes patient reception, treatment areas, private offices, and multiple restrooms.

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    Medical Office Suite with Private Entrance
    Medical Office Suite with Private Entrance

    D-17450 Main St, Hesperia, CA 92345

    $2,448/Mo

    Medical office suite with exam rooms, kitchenette, and dedicated front and rear entry for staff and patient access.

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    Small Medical Office Suite
    Small Medical Office Suite

    B-17450 Main St, Hesperia, CA 92345

    $909.50/Mo
    535 sqft

    Single-story professional center unit with front and rear access, shared parking, and nearby bus service.

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    Private Medical Office Suite
    Private Medical Office Suite

    C-15462 Main St, Hesperia, CA 92345

    Contact for pricing
    678 sqft

    Private office accommodation with exterior access, a dedicated office, open workspace, and an on-site restroom.

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    Medical Office Space Available
    Medical Office Space Available

    15462 Main St, Hesperia, CA 92345

    Contact for pricing

    Private office space in medical building with exterior access.

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    Based on your search, we've compiled 16 Potential Opportunities for your consideration. Besides 12 Active listings in Hesperia, CA, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities

    Medical Office Space for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Medical Office Suite with Pool Area
    Medical Office Suite with Pool Area

    D-18145 Us Highway 18, Apple Valley, CA 92307

    Contact for pricing
    4,900 sqft

    Suite D offers a flexible medical layout with multiple offices, exam rooms, restrooms, and an indoor pool area.

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    Medical Office Space
    Medical Office Space

    202-15995 Tuscola Rd, Apple Valley, CA 92307

    Contact for pricing
    975 sqft

    Medical office space with 20 shared front parking spaces and 12 rear spaces, near St Mary's Hospital.

    View details
    Renovated Medical Office Suite
    Renovated Medical Office Suite

    15980 Bear Valley Rd, Victorville, CA 92395

    Contact for pricing
    4,330 sqft

    Renovated medical office space with major system upgrades completed in 2017.

    View details
    Freestanding Medical Office Building
    Freestanding Medical Office Building

    Victorville, CA 92395

    Contact for pricing

    Renovated in 2017 with C-1 zoning and convenient Interstate 15 access.

    View details

    Hesperia, CA Medical Office Space Lease Rates & Market Statistics

    Explore 12 Medical Office Space listings for lease in Hesperia, CA on Realmo, a commercial real estate exchange covering the Hesperia area. The current inventory totals 26,189 square feet of properties — an average of ~2,200 SF per listing.

    Asking lease rates for Medical Office Space in Hesperia start at $3.75 SF/Yr, average $16.62 SF/Yr, and reach $30.88 SF/Yr at the top of the market. That's a 8x spread between entry-level and premium space, making side-by-side comparison of asking rents and lease terms essential. At $16.62 SF/Yr, the local average runs 35% below California's state average of $25.44 SF/Yr.

    Hesperia accounts for 12% of the 102 medical office space listings currently available across San Bernardino County, where nearby markets include Apple Valley and Victorville. Medical Office Space listings make up 38% of the 32 Office Spaces currently for lease in Hesperia, with asking rates in line with the citywide Office Spaces average. Tenants comparing options may also consider Office Units (28 listings) elsewhere in the Hesperia market.

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