Poplar Bluff, MO Office buildings for Rent & Lease

Updated: Jul 14

Warehouse and Office Flex Facility

1716 Harper Street, Poplar Bluff, MO 63901

$15,000/Mo

23,500 sqft

Newly constructed flex/commercial lease at 1716 Harper Street, Poplar Bluff, MO
15,000 SF ground‑floor space plus 8,500 SF heavy‑duty second‑floor storage that can be finished to suit
Front includes 8,500 SF premium office space: large lobby, reception, 4 private offices, conference room, and 3 open‑air workstations
Industrial area features 3 large overhead doors and a loading dock, plus an 8,500 SF upper deck
5.5 baths and a full kitchen; automated power shades on street‑front windows

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Updated: Nov 13, 2025

Historic Office Building

433 N Main St, Poplar Bluff, MO 63901

$5,000/Mo

Restored 1912 historic office building with original hardwood floors, rich millwork, and preserved architectural details
Main level includes reception area, two waiting rooms, full kitchen, and break room
Flexible layout: either 2 conference rooms and 5 offices or 1 conference room and 6 offices
2.5 restrooms total—1.5 on the main level and one on the upper level
Basement level offers additional office space with a handicap‑accessible entrance

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Turn Any Listing Into an Investment Snapshot Owner equity, real caprate, demand score for every listing. Go To Analytics Center

Based on your search, we've compiled 13 Potential Opportunities for your consideration. Besides 2 Active listings in Poplar Bluff, MO, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 3 Properties for Sales.

Office buildings for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Renovated Office Building with Road Frontage

230 N Sprigg Street, Cape Girardeau, MO 63701

$2,500/Mo

2,937 sqft

Renovated office space with brand-new A/C, roof, and updated interior finishes, offered for sale or lease.

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Downtown Office Building For Lease

18 N. Main, Cape Girardeau, MO 63701

$8,558/Mo

13,694 sqft

13,694 SF office building in historic downtown Cape Girardeau.

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Custom Office Building with Furnishings

2804 Longview Drive, Jonesboro, AR 72401

$13,000/Mo

9,224 sqft

Custom-built office setup includes 12 private offices, 12 workstations, and meeting space plus furnished interiors.

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Lifestyle Office Development with Amenities

1680 Hl Pk Cv, Jonesboro, AR 72401

$30 SF/Yr

8,000 sqft

Office space in a 27-acre lifestyle-oriented development.

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Similar Spaces for Sale in Poplar Bluff, MO

Consider Similar Space for Sale. We found 3 Spaces matching your search parameters.

Commercial Office or Retail Space

922 Pine Street, Poplar Bluff, MO 63901

$129,900

Versatile commercial property offers a flexible layout for office or retail use in a high-visibility area.

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Concrete-Truss Office Building

115 S Main St, Poplar Bluff, MO 63901

Contact for pricing

9,600 sqft 1.00 AC lot

Concrete and steel-truss office building with concrete floors, updated roof and LED lighting, plus updated restrooms and plumbing.

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Commercial Development Lot

1890 N Westwood Blvd, Poplar Bluff, MO 63901

$685,000

For sale commercial lot at 1890 N Westwood Blvd in Poplar Bluff, suited for a range of development concepts.

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Potential Development Sites for Consideration

Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

Office Development Land For Lease

1323 Strawfloor Drive, Jonesboro, AR 72401

Contact for pricing

4,000 sqft

2.43 acres for office development with build-to-suit opportunity.

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Class A Office Suite with Bullpen

1902 Vandalia Street, Collinsville, IL 62234

$5,000/Mo

Recently built office space with private offices, bullpen, and modern amenities for professional teams.

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Corner Lot on Highway 72

30472 Highway 72, Madison, AL 35756

$5,000/Mo

1,875 sqft

1.7 acre corner lot zoned for commercial, medical, residential.

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Build-to-Suit Office Development Site

5637 Paluxy Dr, Tyler, TX 75703

$20,000/Mo

20,000 sqft

2.1-acre commercial land parcel available for a build-to-suit office complex supporting multiple square footage requirements.

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