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    Poplar Bluff, MO Mixed-use Properties for Sale

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    Renovated Mixed-Use Commercial Space
    $79,900
    975 SF

    Renovated Mixed-Use Commercial Space

    1614 S Broadway St, Poplar Bluff, MO 63901

    Renovated commercial space with high visibility, suitable for various businesses.

    • Excellent road visibility and strategic location near historic downtown.
    • Flexible layout with two separate entrances and individual bathrooms, ideal for multi‑tenant use or dual business operations.
    • Move‑in ready condition with recent renovations.
    • Attractive listing price.
    • Suitable for a variety of businesses (retail, office, service, studio).
    Updated: Jan 23
    View details
    Mixed-Use Property in Rural Setting
    $220,000
    4,800 SF

    Mixed-Use Property in Rural Setting

    5914 Highway W, Poplar Bluff, MO 63901

    Live and work property bordering national forest near Poplar Bluff.

    • Live/work property bordering national forest in a rural setting.
    • Large shop area (3,120 sq ft) ideal for business or hobbies.
    • Living area (1,680 sq ft) includes kitchen, bathroom, and office/bedroom.
    • Constructed in 2005.
    • Multiple cooling systems: Electric, Multi Units, Wall/Window Unit(s), Window Unit(s).
    Updated: Nov 3, 2025
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    Historic Mixed-Use Building
    Pending
    $299,900
    0.29 Acres

    Historic Mixed-Use Building

    Charming downtown building with storefront and potential living quarters.

    400 Vine St, Poplar Bluff, MO 63901
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    Based on your search, we've compiled 52 Potential Opportunities for your consideration. Besides 3 Active listings in Poplar Bluff, MO, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 45 Off-Market properties to explore as potential leads

    Explore Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Mixed-Use Building in Pocahontas, AR
    $125,000
    6,000 SF

    Mixed-Use Building in Pocahontas, AR

    6,000 sq ft mixed-use building with residential units for sale.

    113 W Pyburn St, Pocahontas, AR 72455
    View details
    Historic Mixed-Use Building in Pocahontas
    $199,900
    3,948 SF

    Historic Mixed-Use Building in Pocahontas

    Early 1900s mixed-use building with retail and residential spaces.

    107 N Marr St, Pocahontas, AR 72455
    View details
    Mixed-Use Property in Historic Downtown
    $295,000
    5,420 SF

    Mixed-Use Property in Historic Downtown

    Mixed-use property with commercial space and residential apartments in Paragould.

    211 N Pruett St, Paragould, AR 72450
    View details
    Downtown Paragould Mixed-Use Building
    $299,900
    4,200 SF

    Downtown Paragould Mixed-Use Building

    Prime location, 4,200 sq ft, restaurant-ready.

    310 Pruett St, Paragould, AR 72450
    View details

    Explore Off-Market Properties in Poplar Bluff, MO

    Consider similar Off-Market properties in Poplar Bluff, MO. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    67 St

    67 St

    OFFICE/RESIDENTIAL (MIXED USE) • 0.24 Acres
    Value Estimation by Request
    67 St, Poplar Bluff, MO 63901
    View details
    946 Lester St

    946 Lester St

    STORE/OFFICE (MIXED USE) • 4,457 SF
    Value Estimation by Request
    946 Lester St, Poplar Bluff, MO 63901-4936
    View details
    Of Northwood Dr

    Of Northwood Dr

    STORE/OFFICE (MIXED USE) • 9,360 SF
    Value Estimation by Request
    Of Northwood Dr, Poplar Bluff, MO 63901
    View details
    Poplar Bluff, MO 63901

    Poplar Bluff, MO 63901

    STORE/OFFICE (MIXED USE) • 2,048 SF
    Value Estimation by Request
    Poplar Bluff, MO 63901
    View details
    400 Vine St

    400 Vine St

    STORES & APARTMENTS • 4,050 SF
    Value Estimation by Request
    400 Vine St, Poplar Bluff, MO 63901-5838
    View details
    1106 1110th Vine

    1106 1110th Vine

    STORE/OFFICE (MIXED USE) • 6,270 SF
    Value Estimation by Request
    1106 1110th Vine, Poplar Bluff, MO 63901
    View details
    203 Main St

    203 Main St

    STORES & APARTMENTS • 10,511 SF
    Value Estimation by Request
    203 Main St, Poplar Bluff, MO 63901-5146
    View details
    301 Main St

    301 Main St

    STORES & APARTMENTS • 5,645 SF
    Value Estimation by Request
    301 Main St, Poplar Bluff, MO 63901-5833
    View details
    414 Poplar St

    414 Poplar St

    STORE/OFFICE (MIXED USE) • 4,066 SF
    Value Estimation by Request
    414 Poplar St, Poplar Bluff, MO 63901-5828
    View details
    Poplar Bluff, MO 63901

    Poplar Bluff, MO 63901

    STORE/OFFICE (MIXED USE) • 6,878 SF
    Value Estimation by Request
    Poplar Bluff, MO 63901
    View details
    Pp

    Pp

    STORE/OFFICE (MIXED USE) • 25,926 SF
    Value Estimation by Request
    Pp, Poplar Bluff, MO 63901
    View details
    1414 Broadway St

    1414 Broadway St

    STORE/OFFICE (MIXED USE) • 3,876 SF
    Value Estimation by Request
    1414 Broadway St, Poplar Bluff, MO 63901-6338
    View details
    1015 Pne St

    1015 Pne St

    STORE/OFFICE (MIXED USE) • 10,089 SF
    Value Estimation by Request
    1015 Pne St, Poplar Bluff, MO 63901-4839
    View details
    County Rd 572

    County Rd 572

    OFFICE/RESIDENTIAL (MIXED USE) • 2.85 Acres
    Value Estimation by Request
    County Rd 572, Poplar Bluff, MO 63901
    View details
    501 Vine St

    501 Vine St

    STORE/OFFICE (MIXED USE) • 4,884 SF
    Value Estimation by Request
    501 Vine St, Poplar Bluff, MO 63901-7330
    View details
    408 Vine St

    408 Vine St

    STORE/OFFICE (MIXED USE) • 2,911 SF
    Value Estimation by Request
    408 Vine St, Poplar Bluff, MO 63901-5838
    View details
    1336 Westwood Blvd

    1336 Westwood Blvd

    STORE/OFFICE (MIXED USE) • 2,824 SF
    Value Estimation by Request
    1336 Westwood Blvd, Poplar Bluff, MO 63901
    View details
    1337-1339 Westwood

    1337-1339 Westwood

    STORE/OFFICE (MIXED USE) • 3,783 SF
    Value Estimation by Request
    1337-1339 Westwood, Poplar Bluff, MO 63901
    View details
    198 Hwy B B

    198 Hwy B B

    STORE/OFFICE (MIXED USE) • 2,450 SF
    Value Estimation by Request
    198 Hwy B B, Poplar Bluff, MO 63901
    View details
    1135 Lester St

    1135 Lester St

    STORE/OFFICE (MIXED USE) • 5,509 SF
    Value Estimation by Request
    1135 Lester St, Poplar Bluff, MO 63901-4833
    View details
    1341 Westwood Blvd, Unit 1359

    1341 Westwood Blvd, Unit 1359

    STORE/OFFICE (MIXED USE) • 19,648 SF
    Value Estimation by Request
    1341 Westwood Blvd, Poplar Bluff, MO 63901-3313
    View details

    Poplar Bluff, MO Mixed-Use Properties Investment Opportunities Market Analysis

    Explore 48 mixed-use properties for sale in Poplar Bluff, MO, showcased through 3 active listings on our real estate platform. These investment opportunities span a total of 2,427,948 square feet of properties for sale, with an estimated market value of $5,064,800.

    Sale prices for multi use buildings in Poplar Bluff, MO start at $79,900, averaging $460,436, and reaching up to $690,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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