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    Poplar Bluff, MO Mixed-use Properties for Sale

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    Mixed-Use Property in Rural Setting
    $220,000
    4,800 SF

    Mixed-Use Property in Rural Setting

    5914 Highway W, Poplar Bluff, MO 63901

    Live and work property bordering national forest near Poplar Bluff.

    • Live/work property bordering national forest in a rural setting.
    • Large shop area (3,120 sq ft) ideal for business or hobbies.
    • Living area (1,680 sq ft) includes kitchen, bathroom, and office/bedroom.
    • Constructed in 2005.
    • Multiple cooling systems: Electric, Multi Units, Wall/Window Unit(s), Window Unit(s).
    Updated: Nov 3, 2025
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    Renovated Commercial Space, Poplar Bluff
    $84,900
    975 SF

    Renovated Commercial Space, Poplar Bluff

    1614 S Broadway St, Poplar Bluff, MO 63901

    Renovated mixed-use space with high visibility, move-in ready.

    • Excellent road visibility and strategic location near historic downtown.
    • Flexible layout with two separate entrances and individual bathrooms, ideal for multi‑tenant use or dual business operations.
    • Move‑in ready condition with recent renovations.
    • Attractive listing price.
    • Suitable for a variety of businesses (retail, office, service, studio).
    Updated: Dec 16, 2025
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    Based on your search, we've compiled 51 Potential Opportunities for your consideration. Besides 2 Active listings in Poplar Bluff, MO, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 45 Off-Market properties to explore as potential leads

    Explore Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Mixed-Use Building in Pocahontas, AR
    $125,000
    6,000 SF

    Mixed-Use Building in Pocahontas, AR

    6,000 sq ft mixed-use building with residential units for sale.

    113 W Pyburn St, Pocahontas, AR 72455
    View details
    Historic Mixed-Use Building in Pocahontas
    $199,900
    3,948 SF

    Historic Mixed-Use Building in Pocahontas

    Early 1900s mixed-use building with retail and residential spaces.

    107 N Marr St, Pocahontas, AR 72455
    View details
    Mixed-Use Property in Historic Downtown
    $285,000
    5,420 SF

    Mixed-Use Property in Historic Downtown

    Versatile mixed-use property in the heart of downtown Paragould, AR.

    211 N Pruett St, Paragould, AR 72450
    View details
    Downtown Paragould Mixed-Use Building
    $299,900
    4,200 SF

    Downtown Paragould Mixed-Use Building

    Prime location, 4,200 sq ft, restaurant-ready.

    310 Pruett St, Paragould, AR 72450
    View details

    Explore Off-Market Properties in Poplar Bluff, MO

    Consider similar Off-Market properties in Poplar Bluff, MO. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    3338 Westwood Blvd

    3338 Westwood Blvd

    Mixed-use properties • 2,440 SF
    Value Estimation by Request
    3338 Westwood Blvd, Poplar Bluff, MO 63901
    View details
    Kanell Blvd

    Kanell Blvd

    STORE/OFFICE (MIXED USE) • 3,844 SF
    Value Estimation by Request
    Kanell Blvd, Poplar Bluff, MO 63901
    View details
    301 Main St

    301 Main St

    STORES & APARTMENTS • 5,645 SF
    Value Estimation by Request
    301 Main St, Poplar Bluff, MO 63901-5833
    View details
    Poplar Bluff, MO 63901

    Poplar Bluff, MO 63901

    STORE/OFFICE (MIXED USE) • 6,878 SF
    Value Estimation by Request
    Poplar Bluff, MO 63901
    View details
    1337-1339 Westwood

    1337-1339 Westwood

    STORE/OFFICE (MIXED USE) • 3,783 SF
    Value Estimation by Request
    1337-1339 Westwood, Poplar Bluff, MO 63901
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    198 Hwy B B

    198 Hwy B B

    STORE/OFFICE (MIXED USE) • 2,450 SF
    Value Estimation by Request
    198 Hwy B B, Poplar Bluff, MO 63901
    View details
    1015 Pne St

    1015 Pne St

    STORE/OFFICE (MIXED USE) • 10,089 SF
    Value Estimation by Request
    1015 Pne St, Poplar Bluff, MO 63901-4839
    View details
    3012 Westwood Blvd

    3012 Westwood Blvd

    STORE/OFFICE (MIXED USE) • 3,712 SF
    Value Estimation by Request
    3012 Westwood Blvd, Poplar Bluff, MO 63901-6111
    View details
    Hwy 67th N

    Hwy 67th N

    STORE/OFFICE (MIXED USE) • 5,040 SF
    Value Estimation by Request
    Hwy 67th N, Poplar Bluff, MO 63901
    View details
    203 Main St

    203 Main St

    STORES & APARTMENTS • 10,511 SF
    Value Estimation by Request
    203 Main St, Poplar Bluff, MO 63901-5146
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    County Rd 572

    County Rd 572

    OFFICE/RESIDENTIAL (MIXED USE) • 2.85 Acres
    Value Estimation by Request
    County Rd 572, Poplar Bluff, MO 63901
    View details
    67 St

    67 St

    OFFICE/RESIDENTIAL (MIXED USE) • 0.24 Acres
    Value Estimation by Request
    67 St, Poplar Bluff, MO 63901
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    Of Northwood Dr

    Of Northwood Dr

    STORE/OFFICE (MIXED USE) • 9,360 SF
    Value Estimation by Request
    Of Northwood Dr, Poplar Bluff, MO 63901
    View details
    900 Blk Of Pne

    900 Blk Of Pne

    STORE/OFFICE (MIXED USE) • 5,592 SF
    Value Estimation by Request
    900 Blk Of Pne, Poplar Bluff, MO 63901
    View details
    408 Vine St

    408 Vine St

    STORE/OFFICE (MIXED USE) • 2,911 SF
    Value Estimation by Request
    408 Vine St, Poplar Bluff, MO 63901-5838
    View details
    1106 1110th Vine

    1106 1110th Vine

    STORE/OFFICE (MIXED USE) • 6,270 SF
    Value Estimation by Request
    1106 1110th Vine, Poplar Bluff, MO 63901
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    Of County Rd 542

    Of County Rd 542

    OFFICE/RESIDENTIAL (MIXED USE) • 2.40 Acres
    Value Estimation by Request
    Of County Rd 542, Poplar Bluff, MO 63901
    View details
    Of Hwy 60th W

    Of Hwy 60th W

    STORE/OFFICE (MIXED USE) • 799 SF
    Value Estimation by Request
    Of Hwy 60th W, Poplar Bluff, MO 63901
    View details
    1414 Broadway St

    1414 Broadway St

    STORE/OFFICE (MIXED USE) • 3,876 SF
    Value Estimation by Request
    1414 Broadway St, Poplar Bluff, MO 63901-6338
    View details
    67 Ww N

    67 Ww N

    STORE/OFFICE (MIXED USE) • 5,858 SF
    Value Estimation by Request
    67 Ww N, Poplar Bluff, MO 63901
    View details
    Broadway

    Broadway

    STORES & APARTMENTS • 4,928 SF
    Value Estimation by Request
    Broadway, Poplar Bluff, MO 63901
    View details
    1135 Lester St

    1135 Lester St

    STORE/OFFICE (MIXED USE) • 5,509 SF
    Value Estimation by Request
    1135 Lester St, Poplar Bluff, MO 63901-4833
    View details

    Poplar Bluff, MO Mixed-Use Properties Investment Opportunities Market Analysis

    Explore 47 mixed-use properties for sale in Poplar Bluff, MO on our real estate platform. These investment opportunities span a total of 2,415,407 square feet of properties for sale, with an estimated market value of $4,769,900.

    Prices for multi use buildings in Poplar Bluff, MO start at $84,900, averaging $476,990, and reaching up to $690,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you have the most current data.

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