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    Natick, MA Mixed-use Properties for Sale

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    Boston, MA Springfield, MA Worcester, MA
    Downtown Natick Retail Opportunity
    Contact for pricing
    28,422 SF

    Downtown Natick Retail Opportunity

    21 Summer Street, Natick, MA 1760

    Retail space in a newly developed mixed-use building.

    • Prime location in Downtown Natick, across from The Center for Arts in Natick (TCAN), attracting approximately 30,000 patrons annually.
    • Up to 4,800 square feet of street‑level retail space in a newly developed mixed‑use building (Year Built: 2024).
    • Well‑suited for a restaurant with a ventilation shaft for a 16' hood and a partial open‑air concept dining room.
    • Located steps from Natick Common, with high visibility and accessibility to dining, shopping, and entertainment.
    • Convenient transportation via the Natick Center MBTA Commuter Rail station, providing access to Boston.
    Updated: Nov 21, 2025
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    Downtown Natick Mixed-Use Building
    Contact for pricing
    89,500 SF

    Downtown Natick Mixed-Use Building

    45 East Central Street, Natick, MA 1760

    Street-level retail/restaurant space in a newly developed mixed-use building.

    • Prime downtown Natick location with high visibility and foot traffic.
    • Newly developed mixed‑use building with 46 residential units providing built‑in customer base.
    • Flexible space options available from 1,500 to 6,000± square feet, suitable for various uses.
    • Permitted uses include restaurant (with outdoor seating), retail, office, medical, education, and showroom.
    • Close proximity to Natick Common, local dining, shopping, and entertainment.
    Updated: Nov 21, 2025
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    Based on your search, we've compiled 48 Potential Opportunities for your consideration. Besides 2 Active listings in Natick, MA, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 38 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

    Explore Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Upscale Multi-Tenant Commercial Building
    $2,400,000
    11,860 SF

    Upscale Multi-Tenant Commercial Building

    Upscale commercial building with retail, office, and warehouse spaces.

    348 Boston Post, Sudbury, MA 1776
    View details
    Upscale Multi-Tenant Commercial Building
    $2,400,000

    Upscale Multi-Tenant Commercial Building

    Multi-tenant commercial building with retail, office, and warehouse spaces.

    348 Boston Post, Sudbury, MA 1776
    View details
    Mixed-Use Property Near Natick Line
    $1,530,000
    3,487 SF

    Mixed-Use Property Near Natick Line

    Mixed-use property with two-family rental and auto repair potential.

    12-14 Waverly Street, Framingham, MA 1702
    View details
    Framingham Mixed-Use Retail Property
    $3,155,000
    10,240 SF

    Framingham Mixed-Use Retail Property

    10,240 SqFt mixed-use retail and office property for sale.

    665 Cochituate Rd, Framingham, MA 1701
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Natick Redevelopment Opportunity
    $7,200,000

    Natick Redevelopment Opportunity

    3 acres with redevelopment potential in Natick, Massachusetts.

    21 Eliot St, Natick, MA 1760
    View details
    Woonsocket Commercial Land For Sale
    $400,000
    0.14 Acres

    Woonsocket Commercial Land For Sale

    Commercial land with redevelopment potential in a growing, desirable market.

    617 Elm Street, Woonsocket, RI 02895
    View details
    Development Opportunity on Andover Street
    $2,000,000

    Development Opportunity on Andover Street

    Two parcels totaling over 2.1 acres for development.

    1575 Andover St, Tewksbury, MA 1876
    View details
    Smithfield Land For Sale
    $5,500,000
    3.69 Acres

    Smithfield Land For Sale

    Pad ready land with master plan approval in Smithfield.

    250 George Washington Highway, Smithfield, RI 02917
    View details

    Explore Off-Market Properties in Natick, MA

    Consider similar Off-Market properties in Natick, MA. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    54 Eliot St

    54 Eliot St

    OFFICE/RESIDENTIAL (MIXED USE) • 4,301 SF
    Value Estimation
    $1,285,000
    54 Eliot St, Natick, MA 01760
    View details
    49 Summer St

    49 Summer St

    OFFICE/RESIDENTIAL (MIXED USE) • 4,230 SF
    Value Estimation
    $640,000
    49 Summer St, Natick, MA 01760-4521
    View details
    30 Main St

    30 Main St

    OFFICE/RESIDENTIAL (MIXED USE) • 5,112 SF
    Value Estimation by Request
    30 Main St, Natick, MA 01760-3422
    View details
    25 Central St

    25 Central St

    OFFICE/RESIDENTIAL (MIXED USE) • 2,766 SF
    Value Estimation
    $625,000
    25 Central St, Natick, MA 01760-4550
    View details
    303 Main St

    303 Main St

    OFFICE/RESIDENTIAL (MIXED USE) • 1,838 SF
    Value Estimation by Request
    303 Main St, Natick, MA 01760-1118
    View details
    987 Worcester St

    987 Worcester St

    OFFICE/RESIDENTIAL (MIXED USE) • 2,170 SF
    Value Estimation by Request
    987 Worcester St, Natick, MA 01760-2032
    View details
    17 Cochituate St

    17 Cochituate St

    OFFICE/RESIDENTIAL (MIXED USE) • 2,730 SF
    Value Estimation by Request
    17 Cochituate St, Natick, MA 01760-3486
    View details
    254 Main St

    254 Main St

    OFFICE/RESIDENTIAL (MIXED USE) • 2,464 SF
    Value Estimation by Request
    254 Main St, Natick, MA 01760-1152
    View details
    991 Worcester St

    991 Worcester St

    OFFICE/RESIDENTIAL (MIXED USE) • 4,158 SF
    Value Estimation by Request
    991 Worcester St, Natick, MA 01760-2032
    View details
    295 Bacon St

    295 Bacon St

    OFFICE/RESIDENTIAL (MIXED USE) • 3,388 SF
    Value Estimation
    $760,000
    295 Bacon St, Natick, MA 01760-2088
    View details
    161 Pond St

    161 Pond St

    OFFICE/RESIDENTIAL (MIXED USE) • 2,409 SF
    Value Estimation
    $505,000
    161 Pond St, Natick, MA 01760-4320
    View details
    59 Summer St

    59 Summer St

    OFFICE/RESIDENTIAL (MIXED USE) • 4,557 SF
    Value Estimation
    $675,000
    59 Summer St, Natick, MA 01760-4521
    View details
    29 Central St

    29 Central St

    OFFICE/RESIDENTIAL (MIXED USE) • 2,527 SF
    Value Estimation
    $505,000
    29 Central St, Natick, MA 01760-4501
    View details
    4 Wellesley Rd

    4 Wellesley Rd

    OFFICE/RESIDENTIAL (MIXED USE) • 2,578 SF
    Value Estimation by Request
    4 Wellesley Rd, Natick, MA 01760-1428
    View details
    31 Main St

    31 Main St

    OFFICE/RESIDENTIAL (MIXED USE) • 45,676 SF
    Value Estimation
    $6,940,000
    31 Main St, Natick, MA 01760-4960
    View details
    1 Main St

    1 Main St

    OFFICE/RESIDENTIAL (MIXED USE) • 7,404 SF
    Value Estimation
    $1,065,000
    1 Main St, Natick, MA 01760-3403
    View details
    13 Central St

    13 Central St

    OFFICE/RESIDENTIAL (MIXED USE) • 26,780 SF
    Value Estimation
    $3,950,000
    13 Central St, Natick, MA 01760-4560
    View details
    39 Main St

    39 Main St

    OFFICE/RESIDENTIAL (MIXED USE) • 4,514 SF
    Value Estimation
    $685,000
    39 Main St, Natick, MA 01760-4948
    View details
    6 Dewey St

    6 Dewey St

    OFFICE/RESIDENTIAL (MIXED USE) • 3,012 SF
    Value Estimation
    $545,000
    6 Dewey St, Natick, MA 01760-4602
    View details
    41 Central St

    41 Central St

    OFFICE/RESIDENTIAL (MIXED USE) • 4,368 SF
    Value Estimation
    $740,000
    41 Central St, Natick, MA 01760-4503
    View details
    45 Central St

    45 Central St

    OFFICE/RESIDENTIAL (MIXED USE) • 3,960 SF
    Value Estimation
    $680,000
    45 Central St, Natick, MA 01760-4503
    View details
    11 Ss Ave

    11 Ss Ave

    OFFICE/RESIDENTIAL (MIXED USE) • 12,850 SF
    Value Estimation
    $2,000,000
    11 Ss Ave, Natick, MA 01760-4622
    View details

    Natick, MA Mixed-Use Properties Investment Opportunities Market Analysis

    Explore 40 mixed-use properties for sale in Natick, MA on our real estate platform. These investment opportunities span a total of 85,452 square feet of properties for sale, with an estimated market value of $4,215,000.

    Sale prices for multi use buildings in Natick, MA start at $260,000, averaging $351,250, and reaching up to $625,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Most Searched ZIP Codes in Natick, MA

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