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    Saint Louis, MO Mixed-use Properties for Lease

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    11 properties
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    Mixed-Use Center Office Space
    Updated: Apr 15
    Mixed-Use Center Office Space

    1114 S Brentwood Blvd, Saint Louis, MO 63117

    Contact for pricing
    15,000 sqft
    Up to ±128,000 SF of contiguous Class A office space available.
    Free on‑site covered parking with an approximately 4.6/1,000 SF parking ratio.
    Enjoy on‑site amenities including shared conference center, grab and go mart, and touchless technology.
    Anchored by Aloft Hotels with several on‑site restaurants and shops.
    ±32,000 SF efficient floor plates with excellent glass line.
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    Unique Live-Work Opportunity Near Downtown
    Updated: Nov 24, 2025
    Unique Live-Work Opportunity Near Downtown

    1410-1414 N Broadway, St., Louis, MO

    Contact for pricing
    19,800 sqft
    Rare live/work opportunity with meticulously maintained custom finishes and unique features throughout.
    Substantial space: 19,800 SQ FT over 3 stories plus a full basement with elevator access.
    Flexible layout: 3 separate bays with pass‑throughs, adaptable for various uses.
    Prime location: Close to Horseshoe Casino, Laclede's Landing, Downtown, and I‑44.
    Equipped for business: Includes loading dock, drive‑in door, freight elevator, and passenger elevator.
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    Downtown St. Louis Mixed-Use Building
    Downtown St. Louis Mixed-Use Building

    Saint Louis, MO 63101

    $12.50 SF/Yr
    2,696 sqft

    Mixed-use building with office and retail space in downtown.

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    Prime Retail Space in The Loop
    Prime Retail Space in The Loop

    Saint Louis, MO

    Contact for pricing
    2,715 sqft

    Mixed-use development with retail space in vibrant Loop area.

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    Mixed-Use Property in South City
    Mixed-Use Property in South City

    Saint Louis, MO

    $12 SF/Yr
    870 sqft

    Retail and apartment spaces at Grand and Gravois intersection.

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    Revitalized Mixed-Use Opportunity
    Revitalized Mixed-Use Opportunity

    Saint Louis, MO

    $12 SF/Yr
    4,320 sqft

    Versatile live/work space in University City near Washington University.

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    Mixed-Use Property in South City
    Mixed-Use Property in South City

    Saint Louis, MO 63118

    $12 SF/Yr
    3,166 sqft

    Mixed-use property with retail and apartments in South St. Louis.

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    Historic Mixed-Use Building in Downtown
    Historic Mixed-Use Building in Downtown

    Saint Louis, MO 63103

    $16 SF/Yr
    23,000 sqft

    Art deco building with office and retail spaces for lease.

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    Mixed-Use Space in Riverfront District
    Mixed-Use Space in Riverfront District

    Saint Louis, MO 63102

    Contact for pricing
    6,120 sqft

    Redeveloped mixed-use property with retail/office space for rent.

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    Saint Louis Commercial Property For Lease
    Saint Louis Commercial Property For Lease

    Butler Hill Rd & Lemay Ferry Rd, Saint Louis, MO 63129

    Contact for pricing

    Commercial property available for lease in Saint Louis, Missouri.

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    Mixed-Use District Retail/Office Space
    Mixed-Use District Retail/Office Space

    Saint Louis, MO 63108

    Contact for pricing

    Bustling mixed-use district with upscale amenities and attractions.

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    Based on your search, we've compiled 46 Potential Opportunities for your consideration. Besides 11 Active listings in Saint Louis, MO, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 27 Properties for Sales.

    Mixed-use properties for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    High-Visibility Commercial Space in Champaign
    High-Visibility Commercial Space in Champaign

    309 S Neil St, Champaign, IL 61820

    $10 SF/Yr

    Versatile commercial space with high visibility and tech-ready infrastructure.

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    New Mixed-Use Development in Edwardsville
    New Mixed-Use Development in Edwardsville

    400 N Main St, Edwardsville, IL 62025

    $30 SF/Yr

    Class A building with retail, office, and restaurant spaces.

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    Premier Mixed-Use Development in Edwardsville
    Premier Mixed-Use Development in Edwardsville

    1010 Enclave Blvd, Edwardsville, IL 62025

    $25 SF/Yr
    2,720 sqft

    Mixed-use development with office/retail suites available for lease.

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    Class A Mixed-Use Development
    Class A Mixed-Use Development

    608 E. University Ave, Champaign, IL 61820

    $16 SF/Yr
    3,370 sqft

    Retail/restaurant/office space available in Champaign near University of Illinois.

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    Similar Spaces for Sale in Saint Louis, MO

    Consider Similar Space for Sale. We found 27 Spaces matching your search parameters.

    Renovated Mixed-Use Historic Building
    Renovated Mixed-Use Historic Building

    7714 S Broadway, St, Louis, MO 63111

    $765,000
    7,680 sqft

    2019 rebuild offers flexible office and retail layout with income-producing upstairs apartments and convenient on-site parking.

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    Mixed-Use Retail and Office Building
    Mixed-Use Retail and Office Building

    3355-59 S Jefferson Avenue, St, Louis, MO 63118

    $850,000
    0.03 AC lot

    Two-parcel mixed-use property with five fully occupied units, including retail and office spaces, with tenants paying utilities.

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    Mixed-Use Building with Daycare
    Mixed-Use Building with Daycare

    8035 N Broadway, St, Louis, MO 63147

    $250,000
    11,972 sqft 0.11 AC lot

    Turnkey mixed-use, 100% occupied building with a daycare on the main level and two residential units upstairs.

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    Mixed-Use Retail and Residential Building
    Mixed-Use Retail and Residential Building

    5001 S Grand Boulevard, St, Louis, MO 63111

    $895,000
    14,000 sqft 0.17 AC lot

    A mixed-use property with three ground-floor retail spaces and 16 residential units for diversified income potential.

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    9707 Chicago Heights Blvd
    9707 Chicago Heights Blvd

    9707 Chicago Heights Blvd, Saint Louis, MO 63132

    $800,000
    16,144 sqft 1.92 AC lot

    Mixed Use Commercial Building/School/Church

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    8-Unit Mixed-Use Building
    8-Unit Mixed-Use Building

    3451-53 S Grand Boulevard, St, Louis, MO 63118

    $220,000
    5,410 sqft 0.16 AC lot

    Mixed-use property with seven 1 bed/1 bath units plus a storefront, basement storage, fenced yard, and detached garage.

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    Duplex Style Office/Mixed-Use Building
    Duplex Style Office/Mixed-Use Building

    2350 Chambers Rd, Saint Louis, MO 63136

    $52,000
    3,500 sqft

    Office or mixed-use building with multiple entrances and possibilities.

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    Downtown St. Louis Investment Opportunity
    Downtown St. Louis Investment Opportunity

    1100 S 6th Street, St, Louis, MO 63104

    $650,000
    16,200 sqft 0.37 AC lot

    Mixed-use building near Busch Stadium with redevelopment potential.

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    Mixed-Use Building with Extra Lots
    Mixed-Use Building with Extra Lots

    1929 E Obear Ave, Saint Louis, MO 63107

    $79,900
    3,400 sqft

    Mixed-use building package includes two additional lots, with construction started and finishes to be completed.

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    Historic Mixed-Use Retail and Office
    Historic Mixed-Use Retail and Office

    3822-24 S Broadway, St, Louis, MO 63118

    $295,000

    Historic mixed-use building offers retail/office bays with tall ceilings and a courtyard plus three income-producing residences.

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    Historic Mixed-Use Redevelopment Opportunity
    Historic Mixed-Use Redevelopment Opportunity

    2317 Cherokee St, Saint Louis, MO

    $635,000
    0.22 AC lot

    Mixed-use property with retail income and apartment redevelopment potential.

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    Leased Mixed-Use Building For Sale
    Leased Mixed-Use Building For Sale

    1800-1804 Lafayette Ave, Saint Louis, MO

    Contact for pricing
    8,200 sqft 0.12 AC lot

    100% leased mixed-use building with recent extensive renovations.

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    Mixed-Use Building on S. Grand
    Mixed-Use Building on S. Grand

    4135 Grand Blvd, Saint Louis, MO 63107

    $210,000

    Mixed-use building with commercial space and residential unit.

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    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    MidTown Corner Lot For Rent
    MidTown Corner Lot For Rent

    1811 Charlotte Avenue, Nashville, TN 37203

    $336/Mo

    Corner lot with high visibility in growing Nashville neighborhood.

    View details
    Prime Commercial Acres For Lease
    Prime Commercial Acres For Lease

    4.12 Acres Al Highway 35, Rainsville, AL 35986

    $6,000/Mo

    4.12 acres of commercial land for lease in Rainsville, AL.

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    Downtown Johnson City Opportunity Zone Land
    Downtown Johnson City Opportunity Zone Land

    213 S Boone St, Johnson City, TN 37604

    Contact for pricing

    Land in Opportunity Zone with mixed-use development plans.

    View details
    Highway 9 Development Opportunity
    Highway 9 Development Opportunity

    1800 Ann Branden Blvd, Norman, OK 73069

    Contact for pricing

    32.55 acres for mixed-use development along Highway 9.

    View details

    Saint Louis, MO Mixed-use properties Market Trends and Statistics

    Explore Mixed-use properties leasing options in Saint Louis, MO with 11 listings featured on our commercial real estate exchange. The current inventory includes 34,052 square feet of properties with an estimated lease value of $64.50 SF/Yr.

    Estimated lease rates for Mixed-use properties in Saint Louis, MO begin at $12 SF/Yr, with an average of $12.90 SF/Yr and extend to $16 SF/Yr.
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    Most Searched ZIP Codes in Saint Louis, MO

    • 63101
    • 63102
    • 63103
    • 63108
    • 63117
    • 63118
    • 63129

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