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    South Dakota Medical Office Space for Sale

    9 results
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    Renovated Commercial Building in Spearfish
    $998,500
    2,400 SF

    Renovated Commercial Building in Spearfish

    747 Ames Avenue, Spearfish, SD 57783

    High-visibility commercial building with tenants in place.

    • High‑visibility and high‑traffic location in the heart of Spearfish.
    • Newer (built in 2007), completely renovated commercial building.
    • Currently has tenants in place (chiropractic office and spa) providing immediate investment income.
    • Luxurious spa and chiropractic office layout with 5 offices and 2 bathrooms.
    • Renovations include new windows, luxury vinyl flooring, maintenance‑free siding, and quality Malarkey Legacy shingles.
    Updated: Oct 20, 2025
    View details
    Dakota Dunes Office Condo
    $450,000
    2,800 SF

    Dakota Dunes Office Condo

    383 W Steamboat Dr, Ste 201, Dakota Dunes, SD 57049

    2,800 SF office condo in Dakota Dunes, SD for sale.

    • 2,800 SF office condo in Dakota Dunes, SD.
    • Finished as a dental office with waiting room, reception, five exam rooms, two offices, and a procedure room.
    • Includes a 3,038 SF basement.
    • Recently updated.
    • Great natural light.
    Updated: Mar 6
    View details
    Dakota Dunes Office Condo
    $450,000
    2,800 SF

    Dakota Dunes Office Condo

    2,800 SF office condo in Dakota Dunes, South Dakota.

    383 W Steamboat Dr, Ste 201, Dakota Dunes, SD 57049
    View details
    Sioux Falls Adaptable Commercial Building
    $2,250,379
    49,424 SF

    Sioux Falls Adaptable Commercial Building

    49,424 SF vacant building suitable for daycare, medical, or office.

    4800 N 4th Ave, Sioux Falls, SD 57104
    View details
    Sioux Falls Medical Office
    $1,400,000
    6,858 SF

    Sioux Falls Medical Office

    Medical office building with exam rooms and updated infrastructure.

    208 W 37th St, Sioux Falls, SD
    View details
    Sioux Falls Office/Medical Building
    $1,980,000
    9,288 SF

    Sioux Falls Office/Medical Building

    Office/medical building with flexible space and ample parking.

    4904-4912 S Minnesota Ave, Sioux Falls, SD
    View details
    Rapid City Medical Corridor Property
    $1,049,000
    5,527 SF

    Rapid City Medical Corridor Property

    Single tenant NNN investment property in Rapid City medical corridor.

    625 Flormann St, Rapid City, SD
    View details
    Aberdeen Office/Medical Building For Sale
    $1,500,000
    19,600 SF

    Aberdeen Office/Medical Building For Sale

    Office/medical building on former Presentation College campus with ample parking.

    1500 N Main St, Aberdeen, SD 57401
    View details
    Dakota Dunes Office Condo
    $450,000
    2,800 SF

    Dakota Dunes Office Condo

    2,800 SF office condo, currently a dental office.

    383 W Steamboat Dr, Dakota Dunes, SD 57049
    View details
    Based on your search, we've compiled 232 Potential Opportunities for your consideration. Besides 9 Active listings in South Dakota, we suggest exploring several alternatives: similar 223 Off-Market properties to explore as potential leads

    Explore Off-Market Properties in South Dakota

    Consider similar Off-Market properties in South Dakota. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    6301 41st St

    6301 41st St

    MEDICAL BUILDING • 3,108 SF
    Value Estimation
    $2,000,000
    6301 41st St, Sioux Falls, SD 57106-1217
    View details
    101 37th St

    101 37th St

    DENTAL BUILDING • 11,259 SF
    Value Estimation by Request
    101 37th St, Sioux Falls, SD 57105-5701
    View details
    2600 Western Ave

    2600 Western Ave

    DENTAL BUILDING • 2,948 SF
    Value Estimation by Request
    2600 Western Ave, Sioux Falls, SD 57105-4429
    View details
    2301 Lorraine Pl

    2301 Lorraine Pl

    DENTAL BUILDING • 1.66 Acres
    Value Estimation by Request
    2301 Lorraine Pl, Sioux Falls, SD 57106-3642
    View details
    809 Belfast St

    809 Belfast St

    MEDICAL BUILDING • 2,482 SF
    Value Estimation by Request
    809 Belfast St, Yankton, SD 57078-3324
    View details
    1700 Southeastern Ave

    1700 Southeastern Ave

    DENTAL BUILDING • 12,664 SF
    Value Estimation
    $610,000
    1700 Southeastern Ave, Sioux Falls, SD 57103-3227
    View details
    2001 Broadway Ave

    2001 Broadway Ave

    MEDICAL BUILDING • 2,000 SF
    Value Estimation by Request
    2001 Broadway Ave, Yankton, SD 57078-2032
    View details
    2300 Westlake Dr

    2300 Westlake Dr

    DENTAL BUILDING • 10,612 SF
    Value Estimation by Request
    2300 Westlake Dr, Sioux Falls, SD 57106-8527
    View details
    3805 Kiwanis Cir

    3805 Kiwanis Cir

    MEDICAL BUILDING • 4,686 SF
    Value Estimation
    $900,000
    3805 Kiwanis Cir, Sioux Falls, SD 57105-4266
    View details
    1710 Southeastern Ave

    1710 Southeastern Ave

    DENTAL BUILDING • 3,929 SF
    Value Estimation
    $800,000
    1710 Southeastern Ave, Sioux Falls, SD 57103-3381
    View details
    920 Broadway Ave

    920 Broadway Ave

    MEDICAL BUILDING • 25,256 SF
    Value Estimation
    $1,040,000
    920 Broadway Ave, Yankton, SD 57078-3532
    View details
    2521 Western Ave

    2521 Western Ave

    DENTAL BUILDING • 2,146 SF
    Value Estimation by Request
    2521 Western Ave, Sioux Falls, SD 57105-3430
    View details
    4001 Southeastern Ave

    4001 Southeastern Ave

    DENTAL BUILDING • 3,236 SF
    Value Estimation by Request
    4001 Southeastern Ave, Sioux Falls, SD 57103-5305
    View details
    Sioux Falls, SD 57106

    Sioux Falls, SD 57106

    DENTAL BUILDING • 8.27 Acres
    Value Estimation by Request
    Sioux Falls, SD 57106
    View details
    2701 Fox Run Pkwy

    2701 Fox Run Pkwy

    DENTAL BUILDING • 3,016 SF
    Value Estimation by Request
    2701 Fox Run Pkwy, Yankton, SD 57078-5350
    View details

    South Dakota Medical Office Space Investment Opportunities Market Analysis

    Explore 232 medical office space for sale in South Dakota, showcased through 9 active listings on our real estate platform. These investment opportunities span a total of 2,835,612 square feet of properties for sale, with an estimated market value of $32,268,500.

    Sale prices for medical spaces in South Dakota start at $155,000, averaging $370,902, and reaching up to $2,000,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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