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South Dakota Medical Office Space for Sale

9 results
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Renovated Commercial Building in Spearfish
$998,500
2,400 SF

Renovated Commercial Building in Spearfish

747 Ames Avenue, Spearfish, SD 57783

High-visibility commercial building with tenants in place.

  • High‑visibility and high‑traffic location in the heart of Spearfish.
  • Newer (built in 2007), completely renovated commercial building.
  • Currently has tenants in place (chiropractic office and spa) providing immediate investment income.
  • Luxurious spa and chiropractic office layout with 5 offices and 2 bathrooms.
  • Renovations include new windows, luxury vinyl flooring, maintenance‑free siding, and quality Malarkey Legacy shingles.
Updated: Oct 20, 2025
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Dakota Dunes Office Condo
$450,000
2,800 SF

Dakota Dunes Office Condo

383 W Steamboat Dr, Ste 201, Dakota Dunes, SD 57049

2,800 SF office condo in Dakota Dunes, SD for sale.

  • 2,800 SF office condo in Dakota Dunes, SD.
  • Finished as a dental office with waiting room, reception, five exam rooms, two offices, and a procedure room.
  • Includes a 3,038 SF basement.
  • Recently updated.
  • Great natural light.
Updated: Mar 6
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Dakota Dunes Office Condo
$450,000
2,800 SF

Dakota Dunes Office Condo

2,800 SF office condo in Dakota Dunes, South Dakota.

383 W Steamboat Dr, Ste 201, Dakota Dunes, SD 57049
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Sioux Falls Adaptable Commercial Building
$2,250,379
49,424 SF

Sioux Falls Adaptable Commercial Building

49,424 SF vacant building suitable for daycare, medical, or office.

4800 N 4th Ave, Sioux Falls, SD 57104
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Sioux Falls Medical Office
$1,400,000
6,858 SF

Sioux Falls Medical Office

Medical office building with exam rooms and updated infrastructure.

208 W 37th St, Sioux Falls, SD
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Sioux Falls Office/Medical Building
$1,980,000
9,288 SF

Sioux Falls Office/Medical Building

Office/medical building with flexible space and ample parking.

4904-4912 S Minnesota Ave, Sioux Falls, SD
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Rapid City Medical Corridor Property
$1,049,000
5,527 SF

Rapid City Medical Corridor Property

Single tenant NNN investment property in Rapid City medical corridor.

625 Flormann St, Rapid City, SD
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Aberdeen Office/Medical Building For Sale
$1,500,000
19,600 SF

Aberdeen Office/Medical Building For Sale

Office/medical building on former Presentation College campus with ample parking.

1500 N Main St, Aberdeen, SD 57401
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Dakota Dunes Office Condo
$450,000
2,800 SF

Dakota Dunes Office Condo

2,800 SF office condo, currently a dental office.

383 W Steamboat Dr, Dakota Dunes, SD 57049
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Based on your search, we've compiled 232 Potential Opportunities for your consideration. Besides 9 Active listings in South Dakota, we suggest exploring several alternatives: similar 223 Off-Market properties to explore as potential leads

Explore Off-Market Properties in South Dakota

Consider similar Off-Market properties in South Dakota. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

6301 41st St

6301 41st St

MEDICAL BUILDING • 3,108 SF
Value Estimation
$2,000,000
6301 41st St, Sioux Falls, SD 57106-1217
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101 37th St

101 37th St

DENTAL BUILDING • 11,259 SF
Value Estimation by Request
101 37th St, Sioux Falls, SD 57105-5701
View details
2600 Western Ave

2600 Western Ave

DENTAL BUILDING • 2,948 SF
Value Estimation by Request
2600 Western Ave, Sioux Falls, SD 57105-4429
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2301 Lorraine Pl

2301 Lorraine Pl

DENTAL BUILDING • 1.66 Acres
Value Estimation by Request
2301 Lorraine Pl, Sioux Falls, SD 57106-3642
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809 Belfast St

809 Belfast St

MEDICAL BUILDING • 2,482 SF
Value Estimation by Request
809 Belfast St, Yankton, SD 57078-3324
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1700 Southeastern Ave

1700 Southeastern Ave

DENTAL BUILDING • 12,664 SF
Value Estimation
$610,000
1700 Southeastern Ave, Sioux Falls, SD 57103-3227
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2001 Broadway Ave

2001 Broadway Ave

MEDICAL BUILDING • 2,000 SF
Value Estimation by Request
2001 Broadway Ave, Yankton, SD 57078-2032
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2300 Westlake Dr

2300 Westlake Dr

DENTAL BUILDING • 10,612 SF
Value Estimation by Request
2300 Westlake Dr, Sioux Falls, SD 57106-8527
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3805 Kiwanis Cir

3805 Kiwanis Cir

MEDICAL BUILDING • 4,686 SF
Value Estimation
$900,000
3805 Kiwanis Cir, Sioux Falls, SD 57105-4266
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1710 Southeastern Ave

1710 Southeastern Ave

DENTAL BUILDING • 3,929 SF
Value Estimation
$800,000
1710 Southeastern Ave, Sioux Falls, SD 57103-3381
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920 Broadway Ave

920 Broadway Ave

MEDICAL BUILDING • 25,256 SF
Value Estimation
$1,040,000
920 Broadway Ave, Yankton, SD 57078-3532
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2521 Western Ave

2521 Western Ave

DENTAL BUILDING • 2,146 SF
Value Estimation by Request
2521 Western Ave, Sioux Falls, SD 57105-3430
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4001 Southeastern Ave

4001 Southeastern Ave

DENTAL BUILDING • 3,236 SF
Value Estimation by Request
4001 Southeastern Ave, Sioux Falls, SD 57103-5305
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Sioux Falls, SD 57106

Sioux Falls, SD 57106

DENTAL BUILDING • 8.27 Acres
Value Estimation by Request
Sioux Falls, SD 57106
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2701 Fox Run Pkwy

2701 Fox Run Pkwy

DENTAL BUILDING • 3,016 SF
Value Estimation by Request
2701 Fox Run Pkwy, Yankton, SD 57078-5350
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South Dakota Medical Office Space Investment Opportunities Market Analysis

Explore 232 medical office space for sale in South Dakota, showcased through 9 active listings on our real estate platform. These investment opportunities span a total of 2,835,612 square feet of properties for sale, with an estimated market value of $32,268,500.

Sale prices for medical spaces in South Dakota start at $155,000, averaging $370,902, and reaching up to $2,000,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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