Medical Space

Prosper, TX Medical Office Space for Lease

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Medical Office Suite with Exam Rooms
Updated: Aug 11
Medical Office Suite with Exam Rooms

540 W Frontier Parkway, Prosper, TX 75078

$4,206/Mo
11,718 sqft 3.72 AC lot
1,364 SF medical office suite with five private exam rooms
Exam rooms include sinks and cabinetry; healthcare‑rated electrical lines serve the space
Layout includes reception, private office, two storage closets, wet bar, and two full bathrooms
Private entrance with 24‑hour access and accessible approach with ramp
Located 0.3 miles from N. Preston Rd. and 2 miles from the Dallas Parkway and Dallas North Tollway
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Medical Office End-Cap Suite
Updated: Jun 18
Medical Office End-Cap Suite

2120 Prairie Drive, Prosper, TX 75078

$3,800/Mo
2,374 sqft 0.05 AC lot
2,374‑square‑foot contiguous suite combining Units 901 and 902
Medical use approval within The Offices at Prosper 380
Up to 4 exam rooms with dedicated sinks
Reception area, conference rooms, 2 kitchens, private offices, and multiple restrooms
Building One corner position with Dallas North Tollway and HWY 380 access
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New Office Suite
New Office Suite

2120 Prairie Drive, Prosper, TX 75078

$35 SF/Yr
1,187 sqft 5.58 AC lot

Under-construction workspace includes central HVAC and contemporary architectural finishes.

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End-Cap Medical Office Suite
End-Cap Medical Office Suite

2120 Prairie Dr Unit 901, Prosper, TX 75078

$3,950/Mo
1,187 sqft

Brand-new 2026 end-cap suite with reception, conference, kitchen, private restroom, and three exam rooms.

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Corner Office Unit with Medical Rough-Ins
Corner Office Unit with Medical Rough-Ins

1630 Prosper Trail, Prosper, TX 75078

$3,500/Mo

Unit 310 offers three private offices, reception, conference space, and a substantial kitchen break room.

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New Office Unit in Hays Office Park
New Office Unit in Hays Office Park

291 S Preston Road, Prosper, TX 75078

$3,300/Mo

Newer office unit in Hays Office Park with brick construction, central air, and on-site parking lot access.

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Medical Office Suite End-Cap
Medical Office Suite End-Cap

2120 Prairie Drive, Prosper, TX 75078

$3,950/Mo
0.03 AC lot

Brand-new 2026 end-cap medical office suite with a corner location, designed for patient flow and clinical sink-equipped exam rooms.

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Corner Office Unit
Corner Office Unit

1630 Prosper Trail 310, Prosper, TX 75078

$3,500/Mo
1,350 sqft

Medical-office-ready suite with private rooms, reception space, and substantial natural light.

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New Office Unit with Modern Finishes
New Office Unit with Modern Finishes

703-2120 Prairie Dr, Prosper, TX 75078

$35 SF/Yr
1,187 sqft

Private corner suite with high-efficiency HVAC and a gross lease structure.

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End-Cap Corner Medical Office Suite
End-Cap Corner Medical Office Suite

2120 Prairie Drive 901, Prosper, TX 75078

$3,950/Mo

New 2026 end-cap medical suite with a corner position, reception, conference room, private restroom, kitchen, and three exam rooms.

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Fully Built-Out Office Condo Suite
Fully Built-Out Office Condo Suite

291 S Preston Road 420, Prosper, TX 75078

$3,200/Mo

Move-in ready office suite with private offices, open work areas, and reception, built in 2023 with an NNN lease structure.

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Medical Office End-Cap Suite
Medical Office End-Cap Suite

2120 Prairie Drive, Unit #901, Prosper, TX 75078

Contact for pricing
2,374 sqft

New 2,374 SF medical suite in Prosper, TX for lease.

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Corner Professional Office Unit
Corner Professional Office Unit

2120 Prairie Drive, Suite 401, Prosper, TX 75078

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One-story office unit with modern stone design suited to medical and professional users.

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Turnkey Medical Office Suite
Turnkey Medical Office Suite

1100 S Coit Road, Suite 20, Prosper, TX 75078

Contact for pricing

Built in 2020, this suite in Whispering Gables Office Park offers modern medical office space ready for customization.

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Based on your search, we've compiled 29 Potential Opportunities for your consideration. Besides 14 Active listings in Prosper, TX, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 11 Properties for Sales.

Medical Office Space for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Brand-New Mixed-Use Retail Center
Brand-New Mixed-Use Retail Center

10402 Coit Rd, Frisco, TX 75035

$40 SF/Yr
20,000 sqft

Brand-new shell spaces support office, medical, retail, and service uses with customizable layouts.

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Medical Office Suite with Preston Road Exposure
Medical Office Suite with Preston Road Exposure

3248 S Preston Road, Celina, TX 75009

Contact for pricing
1,000 sqft

Fully finished out professional medical suite for sublease with immediate occupancy and direct exposure to Preston Road.

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Medical Office Building with Signage
Medical Office Building with Signage

3248 S Preston Rd, Celina, TX 75009

Contact for pricing

Stone-faced office building with monument and digital signage facing Preston Road for strong visibility.

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Professional Medical Office Suites
Professional Medical Office Suites

11005 Preston Rd, Frisco, TX 75033

Contact for pricing
1,797 sqft

Two-story professional and medical office building offers suites for custom finish-out starting August 2025.

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Similar Spaces for Sale in Prosper, TX

Consider Similar Space for Sale. We found 11 Spaces matching your search parameters.

Medical Office End-Cap Suite
Medical Office End-Cap Suite

2120 Prairie Drive, Prosper, TX 75078

$1,044,000
2,374 sqft

Contiguous professional layout includes reception, conference rooms, kitchens, restrooms, and clinical rooms.

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Medical Office End-Cap Suite
Medical Office End-Cap Suite

2120 Prairie Drive Unit #901, Prosper, TX 75078

$569,000
1,187 sqft

Newly completed clinical suite with exam rooms, dedicated sinks, and access to major regional routes.

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Medical Office End-Cap Suite
Medical Office End-Cap Suite

2120 Prairie Drive, Prosper, TX 75078

$1,044,000
0.05 AC lot

Under-construction corner suite with reception, exam rooms, private offices, and dedicated clinical sinks.

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End-Cap Medical Office Suite
End-Cap Medical Office Suite

2120 Prairie Drive, Prosper, TX 75078

$569,000
0.03 AC lot

Corner medical suite with reception, exam rooms, clinical sinks, and private restroom.

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New Medical Office Suite
New Medical Office Suite

540 W Frontier Parkway, Prosper, TX 75078

Contact for pricing
11,718 sqft

Five exam rooms, two bathrooms, and a private entrance support clinical operations.

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End-Cap Medical Office Suite
End-Cap Medical Office Suite

901-2120 Prairie Dr, Prosper, TX 75078

Contact for pricing
1,187 sqft

Brand-new 2026 end-cap suite with reception, conference room, kitchen, restroom, and three exam rooms.

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Medical Office Suite in Office Park
Medical Office Suite in Office Park

291 S Preston Road Unit 610, Prosper, TX 75078

Contact for pricing
1,220 sqft

Nearly new 1,220-sf office suite within Hays Office Park, positioned on the NE corner of Preston Road and East First Street.

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Move-In Ready Office Condo Suite
Move-In Ready Office Condo Suite

420-291 S Preston Rd, Prosper, TX 75078

$550,000

Fully finished office suite with private offices, open work areas, and reception space.

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Fully Occupied Medical Office Building
Fully Occupied Medical Office Building

2450 E Prosper Trail, Prosper, TX 75078

Contact for pricing
6,695 sqft

Single-story commercial building with established healthcare and specialty-service occupants under multiple lease structures.

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Medical Office End-Cap Suite
Medical Office End-Cap Suite

2120 Prairie Drive #901 & 902, Prosper, TX 75078

$1,044,000
2,374 sqft

Configured for medical operations with exam rooms, private offices, and dedicated clinical sinks.

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Prosper, TX Medical Office Space Lease Rates & Market Statistics

Explore 14 Medical Office Space listings for lease in Prosper, TX on Realmo, a commercial real estate exchange covering the Prosper area. The current inventory totals 21,377 square feet of properties — an average of ~1,550 SF per listing.

Asking lease rates for Medical Office Space in Prosper start at $4.31 SF/Yr, average $27.43 SF/Yr, and reach $39.93 SF/Yr at the top of the market. That's a 9x spread between entry-level and premium space, making side-by-side comparison of asking rents and lease terms essential. At $27.43 SF/Yr, the local average runs 17% above Texas's state average of $23.44 SF/Yr.

Prosper accounts for 7% of the 192 medical office space listings currently available across Collin County, where nearby markets include Mckinney and Plano. Medical Office Space listings make up 31% of the 45 Office Spaces currently for lease in Prosper, with asking rates averaging $27.43 SF/Yr — 24% below the citywide Office Spaces average of $36.18 SF/Yr. Tenants comparing options may also consider Office Units (40 listings) elsewhere in the Prosper market.

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