Add Listing
    For Lease
    • For Sale
    • For Lease
    • Recently Sold
    • Property Lookup
    • Brokers
    Medical Space
    1
    • Retail
    • Restaurant
    • Office
    • Coworking
    • Medical Space
    • Automotive
    • Industrial
    • Warehouse
    • Flex
    • Hospitality
    • Sports & Entertainment
    • Specialty
    Price
    Price range
    $
    $
    Size
    Property size / sq.ft.
    AI Search

    Orange County, CA Medical Office Space for Lease

    112 results
    List
    Map
    San Juan Capistrano Commercial Suite
    $6,250 / Mo
    2,086 SF

    San Juan Capistrano Commercial Suite

    27442 Calle Arroyo, San Juan Capistrano, CA 92675

    Spacious 2,086 sq ft suite ideal for medical or office.

    • Prime ground floor suite (2,086 sq. ft.) ideal for medical use in San Juan Capistrano.
    • Zoned for medical use with proximity to established medical and dental practices, offering built‑in referral potential.
    • Flexible layout can be divided into separate suites with individual entrances for business growth or rental income.
    • Convenient access to I‑5 Freeway and San Joaquin 73‑Fwy Toll Road with ample nearby parking.
    • Modernized facilities with Spanish‑style architecture, vaulted ceilings, extensive windows, and a full bathroom with shower.
    Updated: Mar 3
    View details
    Orange, CA Commercial Lease Opportunity
    $4,500 / Mo
    2,692 SF

    Orange, CA Commercial Lease Opportunity

    601 E Chapman Ave, Orange, CA 92866

    Classic building near the Plaza, suitable for medical or office use.

    • Great location, just 6 blocks east of the Plaza.
    • Two units available, lease one or both.
    • Private parking in the rear of the building.
    • New floors and fresh paint in both units.
    • Great sign exposure along Chapman Ave.
    Updated: Dec 5, 2025
    View details
    Buena Park Retail/Office Space
    Contact for pricing
    4,400 SF

    Buena Park Retail/Office Space

    Retail or professional space near major attractions and freeways.

    7041 Western Ave, Buena Park, CA 90620
    View details
    Medical Suites in Prime Location
    $3 SF/Yr
    23,732 SF

    Medical Suites in Prime Location

    Medical suites available for lease near John Wayne Airport.

    9 Corporate Park, Irvine, CA 92606
    View details
    Professional Office Space Available
    $1.75 SF/Yr
    59,590 SF

    Professional Office Space Available

    Professional office, medical, or dental spaces available near freeways.

    1403 N Tustin Ave, Santa Ana, CA 92705
    View details
    La Habra Office Suites Available
    $2 SF/Yr
    715 SF

    La Habra Office Suites Available

    Office suites available, including a turnkey dental suite.

    1400 E Las Palmas Dr, La Habra, CA 90631
    View details
    Medical/Office Suites Near Hospitals
    $2 SF/Yr
    63,006 SF

    Medical/Office Suites Near Hospitals

    Three-story building with medical and office suites near freeways.

    1401 N Tustin Ave, Santa Ana, CA 92705
    View details
    Irvine Medical/Office Space For Lease
    Contact for pricing
    34,698 SF

    Irvine Medical/Office Space For Lease

    Medical/office space in Irvine with flexible sizing and ample parking.

    17305 Von Karman Ave, Irvine, CA 92614
    View details
    Medical Building with Convenient Parking
    $3 SF/Yr
    11,627 SF

    Medical Building with Convenient Parking

    Single-story medical building in prime Orange County location.

    2901 E Katella Ave, Orange, CA 92867
    View details
    Laguna Beach Medical Office Space
    $4 SF/Yr
    3,176 SF

    Laguna Beach Medical Office Space

    Medical office space for lease in downtown Laguna Beach.

    265 Laguna Ave, Laguna Beach, CA 92651
    View details
    Garden Grove Office/Medical Building
    $2 SF/Yr
    21,599 SF

    Garden Grove Office/Medical Building

    Professional office/medical building near freeways and amenities.

    12828 Harbor Blvd, Garden Grove, CA 92840
    View details
    Medical Suites Available For Rent
    $3 SF/Yr
    17,594 SF

    Medical Suites Available For Rent

    Multi-tenant medical center with suites available in Tustin, CA.

    17400 Irvine Blvd, Tustin, CA 92780
    View details
    Medical Office Building For Lease
    $1.65 SF/Yr
    8,243 SF

    Medical Office Building For Lease

    Two-story medical office building with high visibility.

    12630 Brookhurst St, Garden Grove, CA 92840
    View details
    Medical Building with High Visibility
    $2 SF/Yr
    9,300 SF

    Medical Building with High Visibility

    Single-story medical building with ample parking and freeway access.

    23321 El Toro Rd, Lake Forest, CA 92630
    View details
    Former Medical Office Space Available
    $1.80 SF/Yr
    17,530 SF

    Former Medical Office Space Available

    Former medical office space for rent in Orange, CA.

    626-650 N Tustin St, Orange, CA 92867
    View details
    Medical/Office Building Near Irvine Spectrum
    $1.95 SF/Yr
    6,800 SF

    Medical/Office Building Near Irvine Spectrum

    Two-story medical and office building with recent renovations and ample parking.

    22921 Triton Way, Laguna Hills, CA 92653
    View details
    Upgraded Medical Office Space Available
    $1.95 SF/Yr
    5,000 SF

    Upgraded Medical Office Space Available

    Plug-and-play medical office space for sublease through 2028.

    25 Enterprise, Aliso Viejo, CA 92656
    View details
    Medical Office Condo For Rent
    $2 SF/Yr
    2,360 SF

    Medical Office Condo For Rent

    Medical office condo featuring private offices, conference room, and balcony.

    30212 Tomas, Rancho Santa Margarita, CA 92688
    View details
    Medical Office Sublease Available
    $3 SF/Yr
    1,872 SF

    Medical Office Sublease Available

    Sublease available through January 31, 2026, featuring multiple exam rooms.

    11100 Warner Ave, Fountain Valley, CA 92708
    View details
    Laguna Niguel Office Space Available
    Contact for pricing
    3,073 SF

    Laguna Niguel Office Space Available

    Ground floor office space with exterior entrances and ample parking.

    28281 Crown Valley Pkwy, Laguna Niguel, CA 92677
    View details
    Medical Office Space in Costa Mesa
    $7,024 / Mo

    Medical Office Space in Costa Mesa

    Professional medical/office building near Irvine, suitable for various specialties.

    3151 Airway Ave, Costa Mesa, CA 92626
    View details
    Anaheim Office Space For Rent
    $1.95 SF/Yr
    31,880 SF

    Anaheim Office Space For Rent

    Office space for rent in North Orange County location.

    5475 E La Palma Ave, Anaheim, CA 92807
    View details
    Freestanding Medical Office in Fullerton
    $33 SF/Yr
    2,350 SF

    Freestanding Medical Office in Fullerton

    Fully improved medical office space for lease in Fullerton.

    125 N Euclid St, Fullerton, CA 92832
    View details
    Renovated Dental Unit For Lease
    $2 SF/Yr
    8,369 SF

    Renovated Dental Unit For Lease

    Recently renovated dental unit in a mid-century modern building.

    501 N Cornell Ave, Fullerton, CA 92831
    View details

    Orange County, CA Medical Office Space Leasing Opportunities Market Analysis

    Explore Medical Office Space leasing options in Orange County, CA with 158 listings featured on our commercial real estate exchange. The current inventory includes 71,963,602,920 square feet of properties with an estimated lease value of $1,091 /Mo.

    Estimated lease rates for Medical Office Space in Orange County, CA begin at $1.25 SF/Yr, with an average of $17 SF/Yr and extend to $78 SF/Yr.
    List
    Map

    Medical Office Space by market

    Browse Medical Office Space for Lease Near Orange, CA

    Popular Categories

    Select Neighborhood

    Google sign-in failed. Please try again or use another login method.
    Sign Up Successful!
    You now have access to more from Realmo!