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    San Antonio, TX Medical Centers for Lease

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    Class A Medical Center Lease Space
    Updated: Oct 6, 2025
    Class A Medical Center Lease Space

    6348 Prue Rd, San Antonio, TX 78240

    $6,050/Mo
    2,515 sqft 7.80 AC lot
    Premier Class A medical lease space available in Oak Hollow Medical Center at 6348 Prue Road and 6427 Old Babcock Road
    Anchor tenant Christus Santa Rosa with surgical center, physical therapy, and imaging center
    Phase One medical suites available for lease from 2,200 SF up to 30,000 SF
    Site is 7.8 acres with high traffic of 12,986 VPD near the corner of Babcock Road and newly widened Prue Road
    New 33,000 SF building scheduled to start construction early next year and complete in December 2027
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    Medical Office in Medical Center
    Updated: Nov 22, 2025
    Medical Office in Medical Center

    21 Spurs Lane, San Antonio, TX 78240

    $33 SF/Yr
    6,646 sqft
    Located in the South Texas Medical Center, providing close access to Med Center hospitals
    In‑house surgery center and STRIC (South Texas Radiology Imaging Center)
    Garage parking available
    Diverse tenant mix offering referral opportunities
    On‑site convenience store
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    Medical Office Building Suites
    Medical Office Building Suites

    9150 Huebner Rd, San Antonio, TX 78240

    Contact for pricing
    3,472 sqft

    Leased medical office building with a multi-practice tenant mix and recent long-term renewals.

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    Turn a Listing Into an Investment Snapshot Cap Rate, Potential NOI, Demand score for every listing. Go To Analytics Center
    Class A Medical Office Space
    Class A Medical Office Space

    3903 Wiseman Blvd, San Antonio, TX 78251

    Contact for pricing
    779 sqft

    Healthcare practices share access to imaging, laboratory services, covered patient drop-off, and free surface parking.

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    Freestanding Medical Office Building
    Freestanding Medical Office Building

    13431-13441 Blanco Rd, San Antonio, TX 78248

    Contact for pricing
    8,000 sqft

    Two-story medical facility with 12 patient rooms and administrative offices, built for immediate healthcare use.

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    Move-In Ready Medical Clinic
    Move-In Ready Medical Clinic

    19016 Stone Oak Pkwy, San Antonio, TX 78258

    Contact for pricing
    1,911 sqft

    Well-maintained medical clinic space with Class A elevated finishes near North Central Baptist Hospital.

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    Medical Office Building
    Medical Office Building

    9150 Huebner Rd, San Antonio, TX 78240

    Contact for pricing
    1,637 sqft

    Medical office building with multiple practices and strong roadway visibility near Babcock and IH-10.

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    Medical Office Building
    Medical Office Building

    9150 Huebner Rd, San Antonio, TX 78240

    Contact for pricing
    1,311 sqft

    Medical office building with an established tenant mix and 42,423 VPD along Huebner Rd.

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    Medical Facility Near Highway 410
    Medical Facility Near Highway 410

    4330 Vance Jackson Road, San Antonio, TX 78230

    Contact for pricing
    16,048 sqft

    Centrally located medical facility near South Texas Medical Center.

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    Medical Office Space with Outdoor Balcony
    Medical Office Space with Outdoor Balcony

    10622 State Hwy 151, San Antonio, TX 78251

    Contact for pricing
    3,852 sqft

    Medical-focused MOB delivered in 2023 with an outdoor balcony, tenant lounge, and electronic directory.

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    Hospital-Attached Medical Office Building
    Hospital-Attached Medical Office Building

    502 Madison Oak Dr, San Antonio, TX 78258

    Contact for pricing
    1,448 sqft

    Five-story, multi-tenant medical office building directly attached to North Central Baptist Hospital.

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    Medical Office with Lab Space
    Medical Office with Lab Space

    8601 Village Dr, San Antonio, TX 78217

    Contact for pricing
    1,750 sqft

    Suite designed for blood testing labs with free patient parking and covered parking, adjacent to Northeast Baptist Hospital.

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    Medical Office Building Suites
    Medical Office Building Suites

    540 Madison Oak Dr, San Antonio, TX 78258

    Contact for pricing
    1,945 sqft

    Move-in-ready medical office suites are available on a hospital campus with skywalk access and 24-hour entry.

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    Medical Office Center
    Medical Office Center

    9150 Huebner Rd, San Antonio, TX 78240

    Contact for pricing
    2,428 sqft

    Medical tenancy includes a recently renewed radiology provider and multiple specialty practices, supported by 42,423 VPD.

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    Medical Lab Space with Parking
    Medical Lab Space with Parking

    8601 Village Dr, San Antonio, TX 78217

    Contact for pricing
    7,180 sqft

    Medical lab space is offered with free and covered patient parking and is adjacent to Northeast Baptist Hospital.

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    Based on your search, we've compiled 31 Potential Opportunities for your consideration. Besides 15 Active listings in San Antonio, TX, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 12 Properties for Sales.

    Medical centers for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Medical Office Space
    Medical Office Space

    1403 Victoria Station Drive, Victoria, TX 77901

    $3,200/Mo
    3,534 sqft 0.36 AC lot

    Brick construction, vinyl flooring, and central air provide a practical setting for healthcare or professional office operations.

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    Medical Office Space
    Medical Office Space

    1403 Victoria Station Dr, Victoria, TX 77901

    $3,200/Mo

    Commercial setting suited to clinical, professional office, clinic, and service-oriented business uses.

    View details
    Medical Outpatient Space on Campus
    Medical Outpatient Space on Campus

    4310 James Casey St, Austin, TX 78745

    Contact for pricing
    4,950 sqft

    Medical outpatient space for physicians on the St. David’s South Austin Medical Center campus.

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    Medical Office Facility
    Medical Office Facility

    7912 Cameron Rd, Austin, TX 78753

    Contact for pricing
    8,024 sqft

    The 2019-built facility includes an existing curb cut on Cameron Road and GR-NP zoning.

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    Similar Spaces for Sale in San Antonio, TX

    Consider Similar Space for Sale. We found 12 Spaces matching your search parameters.

    Versatile Medical/Office Building For Sale
    Versatile Medical/Office Building For Sale

    417 Camden Street, San Antonio, TX 78215

    $1,550,000
    6,755 sqft

    6,755 SF medical/office building with ample parking.

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    Medical Office Building with Flexible Suites
    Medical Office Building with Flexible Suites

    2 Spurs Lane, San Antonio, TX 78240

    Contact for pricing
    8,696 sqft

    Two-story medical office property with existing clinical buildout and configurable suite options.

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    Medical Office Space in Oak Hollow
    Medical Office Space in Oak Hollow

    6348 Prue Rd., San Antonio, TX 78240

    Contact for pricing
    2,515 sqft 7.80 AC lot

    Medical office opportunity within a completed healthcare center with access to Prue Road, Babcock Road, and regional routes.

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    Established Pediatric Extended Care Center
    Established Pediatric Extended Care Center

    5802 Medina Base Rd, San Antonio, TX 78242

    Contact for pricing
    7,405 sqft

    Operating pediatric care center with expansion potential in San Antonio.

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    Freestanding Medical and Therapy Facility
    Freestanding Medical and Therapy Facility

    10002 Camino Bandera, San Antonio, TX 78254

    Contact for pricing
    15,372 sqft

    Freestanding multi-room building with covered entry canopies, paved parking, and a fenced yard on a sizable site.

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    NNN Property with Annual Increases
    NNN Property with Annual Increases

    6306 US Hwy 87 E, San Antonio, TX 78222

    Contact for pricing
    8,000 sqft

    New construction leased to Action Behavior Centers with contractual annual rent increases.

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    Turnkey Surgery Center Condo
    Turnkey Surgery Center Condo

    7272 Wurzbach Rd, San Antonio, TX 78240

    Contact for pricing
    4,200 sqft

    Surgery center condo near San Antonio's medical corridor.

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    Medical Retail Shopping Center
    Medical Retail Shopping Center

    8435 Wurzbach Rd, San Antonio, TX 78229

    Contact for pricing
    3.05 AC lot

    Three-story center combines restaurant, retail, and healthcare tenants under NNN leases.

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    Move-In Ready Medical Office Suites
    Move-In Ready Medical Office Suites

    San Antonio, TX 78233

    Contact for pricing

    Professionally finished two-story suites with ample on-site parking and strong visibility for medical and service users.

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    San Antonio, TX Medical centers Lease Rates & Market Statistics

    Browse 15 Medical centers for lease in San Antonio, TX on Realmo, a commercial real estate marketplace serving the San Antonio area. The current inventory totals 60,922 square feet of properties — an average of ~4,050 SF per listing.

    Medical centers lease rates in San Antonio range from $28.87 SF/Yr at the entry level to $33 SF/Yr at the top of the market, averaging $30.94 SF/Yr. Pricing across the market is relatively uniform, which simplifies like-for-like comparison between listings. At $30.94 SF/Yr, the local average runs 39% above Texas's state average of $22.25 SF/Yr.

    San Antonio accounts for 100% of the 15 medical centers currently available across Bexar County. Medical centers make up 83% of the 18 Healthcare properties currently for lease in San Antonio, with asking rates averaging $30.94 SF/Yr — 27% above the citywide Healthcare properties average of $24.43 SF/Yr.

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    Most Searched ZIP Codes in San Antonio, TX

    • 78240
    • 78258
    • 78217
    • 78251
    • 78230
    • 78248

    Featured San Antonio Real Estate Agencies

    Realmo connects you with licensed San Antonio CRE brokers providing property specifications, local market pricing, and commercial transaction underwriting support.

    Keller Williams Heritage
    2338 N Loop 1604 W Ste 120 San Antonio, TX
    Phone: 12104933030

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