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    Picayune, MS Commercial Real Estate for Sale

    278 results
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    Commercial Buildings on Highway 43
    $219,500
    5,372 SF

    Commercial Buildings on Highway 43

    22033 Highway 43 South, Picayune, MS 39466

    Three commercial buildings totaling 5,372 SF on 2 acres.

    • Three metal buildings totaling 5,372 SF offer substantial space.
    • Building #1 features 2,400 SF with 4 large rollup doors.
    • Building #2 (1,796 SF) includes plumbed half baths and an unfinished office.
    • Building #3 (1,176 SF) is designed as an auto paint booth.
    • Aluminum siding and metal roof construction.
    Updated: Feb 7
    View details
    Turnkey Auto Repair Business
    $325,000
    4,912 SF

    Turnkey Auto Repair Business

    1747 Highway 11 South, Picayune, MS 39466

    Established auto repair business on 1.82 acres.

    • Established auto repair business on a busy highway.
    • Turnkey business opportunity.
    • Large 1.82‑acre fenced/gated property.
    • Seven 12x14 bay doors.
    • Office area and .5 bath.
    Updated: Dec 22, 2025
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    Commercial Space with Roll-Up Doors
    $280,000
    7,250 SF

    Commercial Space with Roll-Up Doors

    Commercial space with roll-up doors, ideal for various businesses.

    105 S Columbia St, Picayune, MS 39466
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    Prime Commercial Building in Picayune
    $399,900
    3,915 SF

    Prime Commercial Building in Picayune

    Spacious commercial building with multiple suites in prime location.

    707 Memorial Blvd, Picayune, MS 39466
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    Profitable Cinema on High-Traffic Location
    $1,150,000
    10,800 SF

    Profitable Cinema on High-Traffic Location

    10,800 sq. ft. cinema on 1.9 acres near I-59.

    997 Cooper Rd, Picayune, MS 39466
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    Retail Space Near Walmart
    Contact for pricing
    1,500 SF

    Retail Space Near Walmart

    Commercial retail space available, 1500 sq ft, near Hwy 43.

    1407 Armand Dr, Picayune, MS 39466
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    Commercial Property on 3.4 Acres
    $640,000
    21,350 SF

    Commercial Property on 3.4 Acres

    Three buildings on 3.4 acres, suitable for various commercial uses.

    1007 Highway 11 South, Picayune, MS 39466
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    Versatile Commercial Property on Highway
    $650,000
    6,755 SF

    Versatile Commercial Property on Highway

    6,755 sq ft commercial property on 1.32 acres.

    2467 Highway 43 South, Picayune, MS 39466
    View details
    Picayune Warehouse on Two Acres
    $284,500
    7,500 SF

    Picayune Warehouse on Two Acres

    7,500 SF warehouse on 2 acres with office space.

    1817 Palestine Rd, Picayune, MS 39466
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    Picayune Commercial Building For Sale
    $450,000
    3,064 SF

    Picayune Commercial Building For Sale

    3,010 sq ft building on 1.02 acres near I-59.

    2508 Highway 43 S, Picayune, MS 39466
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    Restaurant Ready Commercial Property
    $149,500
    1,727 SF

    Restaurant Ready Commercial Property

    Commercial property with restaurant equipment included, ready for operation.

    728 West Canal St, Picayune, MS 39466
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    Picayune, MS Wooded Land
    $405,000
    45.00 Acres

    Picayune, MS Wooded Land

    45 acres of wooded land with highway frontage.

    S Leetown And Hwy 43, Picayune, MS 39466
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    Remodeled Commercial Property with High Visibility
    $315,000
    952 SF

    Remodeled Commercial Property with High Visibility

    Remodeled commercial property with high visibility and many added features.

    1307 Hwy. 11 South, Picayune, MS 39466
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    Cleared Commercial Land Ready
    $129,000
    2.46 Acres

    Cleared Commercial Land Ready

    2.5-acre commercial property with high visibility and utilities available.

    299 Frontage Rd, Picayune, MS 39466
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    Prime Commercial Land I-59 Frontage
    $995,000
    4.60 Acres

    Prime Commercial Land I-59 Frontage

    High-visibility commercial land with I-59 frontage at Exit 4.

    00 I59, Picayune, MS 39466
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    Prime Highway 11 Vacant Lot
    $784,080
    2.09 Acres

    Prime Highway 11 Vacant Lot

    Ideally located commercial land on Highway 11 in Picayune.

    00 Highway 11 North, Picayune, MS 39466
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    Prime Vacant Lot Near I-59
    $235,000
    1.41 Acres

    Prime Vacant Lot Near I-59

    Highly visible 1.41-acre lot with easy interstate access.

    Nhn Cooper Rd, Picayune, MS 39466
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    Cleared Land on Highway 43
    $199,900
    13.75 Acres

    Cleared Land on Highway 43

    13.75-acre tract zoned A-1 with road frontage, ready for development.

    19910 Highway 43, Picayune, MS 39466
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    Picayune Church Property for Sale
    $499,000
    4,410 SF

    Picayune Church Property for Sale

    Community church with sanctuary, meeting rooms, and ample parking.

    1700 Goodyear Blvd, Picayune, MS 39466
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    Picayune Vacant Commercial Lot
    $249,000
    1.74 Acres

    Picayune Vacant Commercial Lot

    Commercial lot in a desirable location near Highway 43.

    Parcel C Nhn Wildwood St, Picayune, MS 39466
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    Picayune Vacant Commercial Lot
    $249,000
    1.74 Acres

    Picayune Vacant Commercial Lot

    Vacant commercial land in a desirable location near Highway 43.

    Parcel A Nhn Wildwood St, Picayune, MS 39466
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    Picayune Commercial Land For Sale
    $1,098,000
    5.78 Acres

    Picayune Commercial Land For Sale

    Commercial land available in Picayune, Mississippi, near hospital.

    00 Highland Pkwy, Picayune, MS 39466
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    Picayune Commercial Land For Sale
    $249,000
    1.74 Acres

    Picayune Commercial Land For Sale

    Vacant lot in desirable location near Highway 43 North.

    Parcel B Nhn Wildwood St, Picayune, MS 39466
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    Picayune Commercial Retail Space Available
    $245,000
    10,000 SF

    Picayune Commercial Retail Space Available

    Retail property with highway access in Picayune, Mississippi.

    213 Highway 11 South, Picayune, MS 39466
    View details

    Picayune, MS Commercial Real Estate Investment Opportunities Market Analysis

    Explore 68 commercial real estate for sale in Picayune, MS, showcased through 278 active listings on our real estate platform. These investment opportunities span a total of 10,532,939 square feet of properties for sale, with an estimated market value of $20,610,224.

    Sale prices for business properties in Picayune, MS start at $38,500, averaging $361,582, and reaching up to $1,150,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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