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    Des Moines, IA Commercial Real Estate for Sale

    352 results
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    Adaptable Commercial Space, Des Moines/Ankeny
    $950,000
    1.86 Acres

    Adaptable Commercial Space, Des Moines/Ankeny

    1380 NE 66Th Ave, Des Moines, IA 50313

    Renovated commercial space suitable for retail, office, or service businesses.

    • Extensively renovated in 2017 with modern finishes and updated systems.
    • Highly adaptable layout suitable for retail, office, studio, or service‑oriented businesses.
    • Prime location on NE 66th Avenue in the Des Moines/Ankeny corridor with convenient access and visibility.
    • Recent addition in 2024 enhances functionality and square footage.
    • Move‑in‑ready condition, ideal for immediate occupancy and operation.
    Updated: Jan 26
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    Des Moines Office/Warehouse Opportunity
    $425,000
    1.74 Acres

    Des Moines Office/Warehouse Opportunity

    2679 Maury St, Des Moines, IA 50317

    Over 5000 sq ft building suitable for office or warehouse.

    • Large Building: Over 5000 sq ft of usable space.
    • Ample Parking: 22,000 sq ft of exterior parking area.
    • Flexible Usage: Suitable for office or warehouse purposes.
    • High Ceilings: 12'6" ceiling height.
    • Durable Construction: Brick construction.
    Updated: Nov 29, 2025
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    Des Moines Duplex: Investment Opportunity
    $195,000
    1,282 SF

    Des Moines Duplex: Investment Opportunity

    Charming Des Moines duplex, ideal for investors or homeowners.

    1442 34Th St, Des Moines, IA 50311
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    Automotive Shop in Des Moines
    $325,000
    0.16 Acres

    Automotive Shop in Des Moines

    Fully functioning automotive shop in a high-traffic location.

    1501 6Th Ave, Des Moines, IA 50314
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    Des Moines Land Opportunity
    $300,000
    1.92 Acres

    Des Moines Land Opportunity

    1.92 acres of land suitable for development.

    3101 SE 22Nd St, Des Moines, IA 50320
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    Historic Mixed-Use Property For Sale
    $225,000
    3,550 SF

    Historic Mixed-Use Property For Sale

    Unique mixed-use property with commercial space and residential apartments.

    3516 SW 9Th St, Des Moines, IA 50315
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    Productive Farmland Near Des Moines
    Contact for pricing
    231.09 Acres

    Productive Farmland Near Des Moines

    231-acre farm with high CSR2 rating and highway access.

    Hartford Ave, Des Moines, IA 50320
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    Retail Center on E University
    Pending
    $1,680,000
    0.76 Acres

    Retail Center on E University

    Fully leased retail center with high visibility on E University.

    2910 E University Ave, Des Moines, IA 50317
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    Des Moines Retail Property For Sale
    $1,600,000
    1.09 Acres

    Des Moines Retail Property For Sale

    Retail property available for sale in Des Moines, Iowa.

    606 E Army Post Rd, Des Moines, IA 50315
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    Commercial Land Near Des Moines Airport
    $535,000
    1.42 Acres

    Commercial Land Near Des Moines Airport

    Commercial land near Des Moines Airport, ideal for entrepreneurs.

    2501 Mckinley Ave, Des Moines, IA 50321
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    Profitable ATV Tour Business
    $250,000

    Profitable ATV Tour Business

    Turnkey ATV tour business in Tamarindo, Costa Rica.

    Atv Business Opportunity, Des Moines, IA 50309
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    Des Moines Land Opportunity
    $149,950
    2.49 Acres

    Des Moines Land Opportunity

    2.49-acre parcel with potential for high-density residential conversion.

    2009-2013 Martin Luther King Jr Pkwy, Des Moines, IA 50314
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    Former Dentist Office with Space
    Contact for pricing
    7,260 SF

    Former Dentist Office with Space

    First and second floor office spaces available for lease.

    4919 Douglas Ave, Des Moines, IA 50310
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    Luxury Villas Near Costa Rica Beach
    $799,000
    2,691 SF

    Luxury Villas Near Costa Rica Beach

    Boutique villas, walk to beach, income potential.

    Villas Cabuya, Des Moines, IA 50308
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    Historic Office Condo For Sale
    $335,000
    2,028 SF

    Historic Office Condo For Sale

    Office condo in historic building near Court Avenue District.

    100 Court Ave, Des Moines, IA 50309
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    Retail Investment Opportunity in Des Moines
    $741,000
    3,168 SF

    Retail Investment Opportunity in Des Moines

    Retail property with established tenants in a prime location.

    521 E 14Th St, Des Moines, IA 50316
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    Des Moines Auto Shop For Sale
    $500,000
    3,223 SF

    Des Moines Auto Shop For Sale

    Former auto body shop in high-traffic Des Moines location.

    1424 Army Post Rd, Des Moines, IA 50315
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    Des Moines Office Building For Sale
    $550,000
    8,446 SF

    Des Moines Office Building For Sale

    Office building with ample parking and convenient location for sale.

    5601 Douglas Ave, Des Moines, IA 50310
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    Two-Story Office Building For Sale
    $775,000
    9,100 SF

    Two-Story Office Building For Sale

    Two-story 9,100 SF office building on 1 acre for sale.

    4600 SW 9Th St, Des Moines, IA 50315
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    Des Moines Commercial Corridor Property
    $600,000
    2,507 SF

    Des Moines Commercial Corridor Property

    Well-maintained property in accessible commercial corridor with high visibility.

    3508 Delaware Ave, Des Moines, IA 50313
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    Renovated Office Space For Sale
    $599,000
    3,723 SF

    Renovated Office Space For Sale

    Completely renovated office space with modern finishes and convenient location.

    7177 Hickman Rd, Des Moines, IA 50322
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    Freestanding Retail Building For Sale
    $750,000
    5,514 SF

    Freestanding Retail Building For Sale

    Freestanding retail building with showroom, warehouse, and office space.

    4931 Douglas Ave, Des Moines, IA 50310
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    Medical Office Building For Sale
    $460,000
    3,623 SF

    Medical Office Building For Sale

    Single-story medical office building with University Avenue frontage.

    303 University Ave, Des Moines, IA 50314
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    Des Moines Office Building For Sale
    $389,000
    2,152 SF

    Des Moines Office Building For Sale

    Two-story office building near Des Moines VA Medical Center.

    3811 38Th St, Des Moines, IA 50310
    View details

    Des Moines, IA Commercial Real Estate Investment Opportunities Market Analysis

    Explore 195 commercial real estate for sale in Des Moines, IA, showcased through 352 active listings on our real estate platform. These investment opportunities span a total of 6,239,329 square feet of properties for sale, with an estimated market value of $45,691,798.

    Sale prices for business properties in Des Moines, IA start at $149,950, averaging $1,234,913, and reaching up to $4,950,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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