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    Saint Charles, MO Commercial Real Estate for Sale

    36 results
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    St Charles Industrial/Retail Building
    $650,000
    2,640 SF

    St Charles Industrial/Retail Building

    4516 S St Peters Pkwy, Saint Charles, MO 63304

    Free-standing building with highway visibility and multiple drive-in doors.

    • Excellent location with great highway visibility and easy access to Hwy 364.
    • Free‑standing building suitable for Commercial, Retail, or Light Industrial use.
    • Over 2,500 SF building on nearly an acre lot.
    • Six drive‑in doors for convenient access.
    • Approximately 35 parking spaces available.
    Updated: Feb 27
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    St Charles Development Opportunity
    $1,168,100
    9.09 Acres

    St Charles Development Opportunity

    365 Clarence Dr, Saint Charles, MO 63303

    9.09 acres of land in a prime location.

    • Prime location with Arena Parkway frontage.
    • 9.09 acres of land available.
    • Development opportunity with potential for mixed‑use conversion.
    • Zoned R1E, offering development flexibility.
    • Only 1 block off the Page extension.
    Updated: Dec 29, 2025
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    St Charles Development Opportunity
    $1,168,100
    9.09 Acres

    St Charles Development Opportunity

    9.09 acres of land in prime location for development.

    365 Clarence Dr, Saint Charles, MO 63303
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    Prime Commercial Land Opportunity
    $450,000
    1.41 Acres

    Prime Commercial Land Opportunity

    1.41 acres with high visibility and utilities on site.

    2025 S Old Highway 94, Saint Charles, MO 63303
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    Commercial Lot on Harry Truman
    $440,000
    0.84 Acres

    Commercial Lot on Harry Truman

    Highly visible commercial lot suitable for various business ventures.

    3735 Harry S Truman Blvd, Saint Charles, MO 63301
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    St Charles Commercial Land ForSale
    $449,000
    0.98 Acres

    St Charles Commercial Land ForSale

    Commercial land in high-traffic St Charles location, ideal for retail.

    8 Plaza Way, Saint Charles, MO 63303
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    Former QSR on Large Site
    $795,000
    2,300 SF

    Former QSR on Large Site

    High-visibility property suitable for retail, service, or office users.

    2525 West Clay St, Saint Charles, MO 63301
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    Retail Center on Highway 94
    Contact for pricing
    51,474 SF

    Retail Center on Highway 94

    Retail center with high visibility and easy highway access.

    1030-1120 Wolfrum Rd, Saint Charles, MO 63304
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    Redevelopment Opportunity Near Government Center
    $950,000
    4,545 SF

    Redevelopment Opportunity Near Government Center

    Retail building on corner lot near proposed City Hall.

    512 Clark St, Saint Charles, MO 63301
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    Restaurant Space Near Interstate I-70
    $2,200,000
    4,926 SF

    Restaurant Space Near Interstate I-70

    Former restaurant space with high visibility near I-70.

    1423 S 5Th St, Saint Charles, MO 63301
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    Main Street Mixed-Use Building
    $750,000

    Main Street Mixed-Use Building

    Multi-story building with restaurant, retail, office, and residential potential.

    138 N Main St, Saint Charles, MO 63301
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    Freestanding NNN Restaurant For Sale
    $1,302,731

    Freestanding NNN Restaurant For Sale

    Single tenant Captain D's with drive-thru in retail corridor.

    2951 Veterans Memorial Pkwy, Saint Charles, MO 63303
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    Saint Charles Office/Flex Building
    Contact for pricing

    Saint Charles Office/Flex Building

    Class A office/flex building in a prime Saint Charles location.

    500 Fountain Lakes Blvd, Saint Charles, MO 63301
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    Industrial Property with Outdoor Storage
    Contact for pricing
    14,470 SF

    Industrial Property with Outdoor Storage

    14,470 SF building with fenced and covered outdoor storage.

    2715 Veterans Memorial Pkwy, Saint Charles, MO 63303
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    St Charles Unimproved Industrial Land
    $3,103,800
    110.80 Acres

    St Charles Unimproved Industrial Land

    110.8 acres of land suitable for industrial development.

    Huster Rd, Saint Charles, MO 63301
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    1.57 Acres High Visibility Land
    $1,200,000

    1.57 Acres High Visibility Land

    1.57 acres of land with extremely high visibility.

    S Old Highway 94, Saint Charles, MO 63303
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    Saint Charles Adaptable Commercial Building
    Contact for pricing
    8,128 SF

    Saint Charles Adaptable Commercial Building

    8,128 SF building suited for various uses in Saint Charles.

    1821 S River Rd, Saint Charles, MO 63303
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    Historic Mixed-Use Building in Frenchtown
    $980,000
    8,218 SF

    Historic Mixed-Use Building in Frenchtown

    Mixed-use building with retail and apartments in historic Frenchtown.

    900 N 2Nd St, Saint Charles, MO 63301
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    4.76 Acre Business Park Site
    Contact for pricing
    4 SF

    4.76 Acre Business Park Site

    4.76 acre site in established business park with utilities.

    I-370 And Elm St, Saint Charles, MO 63301
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    Class A Office/Flex Building
    Contact for pricing
    53,932 SF

    Class A Office/Flex Building

    Office/flex building with heavy power and potential for warehouse conversion.

    500 Fountain Lakes Blvd, Saint Charles, MO 63301
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    Auto Shop with Retail Store
    Contact for pricing

    Auto Shop with Retail Store

    Two buildings on 1.11 acres near Historic Main Street.

    1513 N 2Nd St, Saint Charles, MO 63301
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    Commercial Land Near Highway Exit
    Contact for pricing

    Commercial Land Near Highway Exit

    Commercially zoned land with high traffic near highway exit.

    Little Hills Expy, Saint Charles, MO 63301
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    Industrial Land Ready For Development
    $499,000

    Industrial Land Ready For Development

    2.5 acres of industrial land with high visibility.

    400 Fountain Lakes Blvd, Saint Charles, MO 63301
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    Commercial Land Near Highway
    Contact for pricing

    Commercial Land Near Highway

    Commercial land available near major highways.

    936 Hemsath Rd, Saint Charles, MO 63303
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    Saint Charles, MO Commercial Real Estate Investment Opportunities Market Analysis

    Explore 36 commercial real estate for sale in Saint Charles, MO, showcased through 36 active listings on our real estate platform. These investment opportunities span a total of 22,123,689 square feet of properties for sale, with an estimated market value of $27,959,910.

    Sale prices for business properties in Saint Charles, MO start at $399,000, averaging $2,541,810, and reaching up to $12,950,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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