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    Port St Lucie, FL Commercial Real Estate for Lease

    158 results
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    Renaissance Financial
    Contact for pricing

    Renaissance Financial

    Discover many ways to work your way in Renaissance Financial

    30 Indian River Dr, Unit 202, Fort Pierce, FL 34950
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    Quincy Professional Plaza
    $2,200 /Mo
    1,440 SF

    Quincy Professional Plaza

    medical, dentist, insurance, retail

    1803 S 25Th St, Unit Suite 5, Fort Pierce, FL 34947
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    Remodeled Commercial Building with Parking
    $4,500 /Mo
    2,000 SF

    Remodeled Commercial Building with Parking

    3801 Okeechobee Road, Fort Pierce, FL 34947

    2000 sq ft commercial building with parking in Fort Pierce.

    • Completely remodeled interior, including a new bathroom.
    • New roof and new A/C unit.
    • 2000 sq ft commercial building with private parking lot.
    • High ceilings (14 foot).
    • Located on Okeechobee Rd, close to the Turnpike.
    Updated: Feb 4
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    Ocean View Office Suite
    $1,200 /Mo
    4,500 SF

    Ocean View Office Suite

    221 S Ocean Drive, Fort Pierce, FL 34949

    Second-floor office suite with ocean views available for lease.

    • Ocean view office suite
    • Reasonable lease rate for Hutchinson Island location ($1,200/month year 1)
    • New metal roof and impact windows
    • Approximately 1,050 sq ft with entry/conference room + 4 offices + private bathroom
    • Join established businesses (Coldwell Banker, Ryen Marine Insurance Group)
    Updated: Dec 19, 2025
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    Versatile Facility in Fort Pierce
    $5,000 /Mo
    4,028 SF

    Versatile Facility in Fort Pierce

    4,028 SF facility ideal for various uses in Fort Pierce.

    2525 S 25th Street, Fort Pierce, FL 34981
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    Landmark Office Building in Fort Pierce
    $16 SF/Yr

    Landmark Office Building in Fort Pierce

    5,400 SF office space available for lease.

    2222 Colonial Road, Fort Pierce, FL 34950
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    Fort Pierce Commercial Rental Space
    $17 SF/Yr

    Fort Pierce Commercial Rental Space

    Commercial rental with office and warehouse space in Fort Pierce.

    405 Angle Road, Fort Pierce, FL 34947
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    Freestanding Building on US Highway
    $26 SF/Yr

    Freestanding Building on US Highway

    General Commercial zoning ideal for retail, medical, or restaurant.

    10244 S US Highway 1, Port St Lucie, FL 34952
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    Modern Flex Office Spaces Available
    $15 SF/Yr
    1,500 SF

    Modern Flex Office Spaces Available

    Flexible leasing options in a busy industrial corridor.

    3801 Oleander Avenue, Fort Pierce, FL 34982
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    Modern Flex Office Spaces Available
    $15 SF/Yr
    1,500 SF

    Modern Flex Office Spaces Available

    Modern flex office spaces for lease in Fort Pierce, Florida.

    3801 Oleander Avenue, Fort Pierce, FL 34982
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    Modern Flex Office Spaces Available
    $15 SF/Yr
    1,500 SF

    Modern Flex Office Spaces Available

    Flexible leasing options in a busy industrial corridor.

    3801 Oleander Avenue, Fort Pierce, FL 34982
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    Modern Flex Office Spaces Available
    $15 SF/Yr
    1,500 SF

    Modern Flex Office Spaces Available

    Modern flex office spaces for lease in Fort Pierce, FL.

    3801 Oleander Avenue, Fort Pierce, FL 34982
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    Modern Flex Office Spaces
    $15 SF/Yr
    1,500 SF

    Modern Flex Office Spaces

    Modern flex spaces ideal for various businesses, move-in ready.

    3801 Oleander Avenue, Fort Pierce, FL 34982
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    Fort Pierce Office/Warehouse Space
    $10,000 /Mo
    4,648 SF

    Fort Pierce Office/Warehouse Space

    Versatile commercial property on US 1 with high visibility.

    3535 Old Dixie Highway, Fort Pierce, FL 34946
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    5.5 Acre Commercial General Lot
    $1.00 SF/Yr

    5.5 Acre Commercial General Lot

    5.5 acre commercial lot suitable for various industrial uses.

    5501 Orange Avenue, Fort Pierce, FL 34947
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    Fort Pierce Retail Investment Opportunity
    $275,000
    1,155 SF

    Fort Pierce Retail Investment Opportunity

    Commercial property with high visibility, convenient access, and redevelopment potential.

    1901 Orange Avenue, Fort Pierce, FL 34950
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    Medical Office Space For Rent
    $24 SF/Yr

    Medical Office Space For Rent

    Updated medical office space available for rent in Port St. Lucie.

    1801 SE Hillmoor Drive unit: A102, Port St Lucie, FL 34952
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    Port Saint Lucie Retail Opportunity
    $60,000
    15,894 SF

    Port Saint Lucie Retail Opportunity

    Retail space available in Port Saint Lucie, Florida.

    Fort Pierce, FL 34952
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    Fort Pierce Office/Warehouse Opportunity
    $2,200,000

    Fort Pierce Office/Warehouse Opportunity

    11,476 sq. ft. Class B office building for rent.

    3030 N 25th Street, Fort Pierce, FL 34946
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    Lake Whitney Business Park
    $19 SF/Yr
    1,776 SF

    Lake Whitney Business Park

    FOR LEASE 1776 Square Feet Warehouse with Office in St. Lucie West

    Fort Pierce, FL 34986
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    Retail Space in Historic Downtown
    $12 SF/Yr
    10,000 SF

    Retail Space in Historic Downtown

    Prime retail spaces available in historic downtown Fort Pierce.

    0000 2nd Street, Fort Pierce, FL 34950
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    Modern Flex Office Spaces
    $1,900 /Mo
    1,500 SF

    Modern Flex Office Spaces

    Flexible leasing options in a busy industrial corridor.

    3801 Oleander Ave, Fort Pierce, FL 34982
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    Prime Fort Pierce Commercial Spaces
    $22 SF/Yr
    8,204 SF

    Prime Fort Pierce Commercial Spaces

    Office and flex spaces available in historic downtown Fort Pierce.

    500 S Us Highway 1, Fort Pierce, FL 34950
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    Medical Office Space on US-1
    $18 SF/Yr
    5,473 SF

    Medical Office Space on US-1

    Newly renovated medical space with high visibility and convenient access.

    Fort Pierce, FL 34952
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    Port St Lucie, FL Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in Port St Lucie, FL with 158 listings featured on our commercial real estate exchange. The current inventory includes 7,537,655,993 square feet of properties with an estimated lease value of $422 /Mo.

    Estimated lease rates for Commercial real estate in Port St Lucie, FL begin at $2 SF/Yr, with an average of $24 SF/Yr and extend to $40 SF/Yr.
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    Browse Commercial real estate for Lease Near Port St Lucie, FL

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    Most Searched ZIP Codes in Port St Lucie, FL

    • 34952
    • 34986
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    • 34982
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    • 34950
    • 34947
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