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    Saint Helena Island, SC Commercial Real Estate for Sale

    87 results
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    Highway 21 Mixed-Use Opportunity
    $650,000
    0.47 Acres

    Highway 21 Mixed-Use Opportunity

    2123 Sea Island Pkwy, Saint Helena Island, SC 29920

    Versatile property with Hwy-21 frontage, suitable for various uses.

    • Prime Hwy‑21 frontage on Harbor Island with high visibility.
    • Versatile 3,520 SF three‑story building suitable for office, live‑work, residential, or short‑term rental use.
    • Gorgeous Lowcountry water and marsh views.
    • Proximity to Fripp Island, Harbor Island, and Dataw Island.
    • Includes a 1,000 SF utility shed and paved parking lot.
    Updated: Dec 9, 2025
    View details
    St. Helena Island Commercial Property
    $1,450,000
    6.98 Acres

    St. Helena Island Commercial Property

    1760 Sea Island Pkwy, Saint Helena Island, SC 29920

    Commercial property in the heart of St. Helena Island.

    • Successful restaurant currently occupies the property, providing immediate income potential.
    • Zoned C4 Community Center Mixed Use, allowing for diverse development opportunities.
    • Acreage out back offers significant potential for expansion and future development.
    • Completely renovated with new metal roof, flooring, paint, and updated bathrooms.
    • Includes an outdoor covered porch, enhancing the property's appeal.
    Updated: Jan 16
    View details
    Waterfront Townhome on Dataw Island
    $449,000

    Waterfront Townhome on Dataw Island

    Furnished two-bedroom townhome with waterfront views and community amenities.

    2014 Bluff Villas Rd, Saint Helena Island, SC 29920
    View details
    Ocean-Marsh View Condo Villa
    $59,900
    1,080 SF

    Ocean-Marsh View Condo Villa

    Two-bedroom condo with ocean and marsh views, fractional ownership.

    6 Cedar Reef Dr, Saint Helena Island, SC 29920
    View details

    Explore Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Acreage on Saint Helena Island
    $225,000
    10.30 Acres

    Acreage on Saint Helena Island

    10.3 acre parcel with well and underground power.

    Edgewater Downs, Beaufort, SC 29907
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    Deepwater Lot in Beaufort, SC
    $1,195,000
    0.58 Acres

    Deepwater Lot in Beaufort, SC

    Deepwater lot with private dock in premier waterfront community.

    180 Distant Island Dr, Beaufort, SC 29907
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    Residential Land on Lady's Island
    $115,000
    0.47 Acres

    Residential Land on Lady's Island

    Residential land near shopping, medical facilities, and Hunting Island.

    21 Little Creek Rd, Ladys Island, SC 29907
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    Residential Land on Lady's Island
    $118,000
    0.48 Acres

    Residential Land on Lady's Island

    Residential land with creek and marsh views available for construction.

    19 Little Creek Rd, Ladys Island, SC 29907
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Highway Frontage Land Parcel
    $429,000
    3.90 Acres

    Highway Frontage Land Parcel

    Land with flexible zoning and high visibility on Sea Island.

    785 Sea Island Pkwy, Saint Helena Island, SC 29920
    View details
    St. Helena Island Mixed-Use Land
    $429,000
    3.90 Acres

    St. Helena Island Mixed-Use Land

    3.9 acre mixed-use land with development potential.

    785 Sea Island Pkwy, Saint Helena Island, SC 29920
    View details
    St. Helena Island Commercial Land
    $299,000
    1.70 Acres

    St. Helena Island Commercial Land

    1.7 acres of commercial land with highway frontage.

    1860 Sea Island Pkwy, Saint Helena Island, SC 29920
    View details

    Explore Off-Market Properties in Saint Helena Island, SC

    Consider similar Off-Market properties in Saint Helena Island, SC. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    Sea Is Pkwy

    Sea Is Pkwy

    WAREHOUSE, STORAGE • 5,600 SF
    Value Estimation by Request
    Sea Is Pkwy, Saint Helena Island, SC 29920
    View details
    Saint Helena Island, SC 29920

    Saint Helena Island, SC 29920

    MINI-WAREHOUSE, STORAGE • 9,000 SF
    Value Estimation
    $500,000
    Saint Helena Island, SC 29920
    View details
    Saint Helena Island, SC 29920

    Saint Helena Island, SC 29920

    LABOR CAMPS (INDUSTRIAL) • 21.98 Acres
    Value Estimation by Request
    Saint Helena Island, SC 29920
    View details
    10 Polowana Rd

    10 Polowana Rd

    MINI-WAREHOUSE, STORAGE • 490 SF
    Value Estimation by Request
    10 Polowana Rd, Saint Helena Island, SC 29920-3819
    View details
    1732 Longfield Dr

    1732 Longfield Dr

    MINI-WAREHOUSE, STORAGE • 2,736 SF
    Value Estimation
    $655,000
    1732 Longfield Dr, Saint Helena Island, SC 29920
    View details
    1441 Sea Is Pkwy

    1441 Sea Is Pkwy

    MINI-WAREHOUSE, STORAGE • 6,000 SF
    Value Estimation
    $760,000
    1441 Sea Is Pkwy, Saint Helena Island, SC 29920-4003
    View details
    1554 Sea Is Pkwy

    1554 Sea Is Pkwy

    COMMERCIAL (GENERAL) • 1.10 Acres
    Value Estimation by Request
    1554 Sea Is Pkwy, Saint Helena Island, SC 29920-4000
    View details
    1168 Sea Is Pkwy

    1168 Sea Is Pkwy

    RETAIL STORES (PERSONAL SERVICES) • 2,232 SF
    Value Estimation by Request
    1168 Sea Is Pkwy, Saint Helena Island, SC 29920-4305
    View details
    859 Sea Is Pkwy

    859 Sea Is Pkwy

    MOTEL • 17,871 SF
    Value Estimation by Request
    859 Sea Is Pkwy, Saint Helena Island, SC 29920-3903
    View details
    6 Yard Farm Rd

    6 Yard Farm Rd

    RETAIL STORES (PERSONAL SERVICES) • 2.00 Acres
    Value Estimation by Request
    6 Yard Farm Rd, Saint Helena Island, SC 29920
    View details
    90 Ocean Crk Blvd

    90 Ocean Crk Blvd

    GOLF COURSE • 2,736 SF
    Value Estimation
    $23,500,000
    90 Ocean Crk Blvd, Saint Helena Island, SC 29920
    View details
    115 Cee Cee Rd

    115 Cee Cee Rd

    DRIVE-THRU RESTAURANT, FAST FOOD • 770 SF
    Value Estimation by Request
    115 Cee Cee Rd, Saint Helena Island, SC 29920
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    14 Dr Martin Luther King Dr

    14 Dr Martin Luther King Dr

    CHARITABLE ORGANIZATION • 1,728 SF
    Value Estimation by Request
    14 Dr Martin Luther King Dr, Saint Helena Island, SC 29920-5300
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    974 Sea Is Pkwy

    974 Sea Is Pkwy

    COMMERCIAL (GENERAL) • 1.56 Acres
    Value Estimation by Request
    974 Sea Is Pkwy, Saint Helena Island, SC 29920-3904
    View details
    1566 Sea Is Pkwy

    1566 Sea Is Pkwy

    COMMERCIAL (GENERAL) • 1.45 Acres
    Value Estimation by Request
    1566 Sea Is Pkwy, Saint Helena Island, SC 29920-4000
    View details
    1000 Sea Is Pkwy

    1000 Sea Is Pkwy

    OFFICE BUILDING • 2,100 SF
    Value Estimation by Request
    1000 Sea Is Pkwy, Saint Helena Island, SC 29920-4313
    View details
    30 Nautical Watch Way

    30 Nautical Watch Way

    RECREATIONAL, ENTERTAINMENT • 3.72 Acres
    Value Estimation by Request
    30 Nautical Watch Way, Saint Helena Island, SC 29920
    View details
    4 Freda Ln

    4 Freda Ln

    GROCERY, SUPERMARKET • 300 SF
    Value Estimation by Request
    4 Freda Ln, Saint Helena Island, SC 29920-6404
    View details
    572 Sea Is Pkwy

    572 Sea Is Pkwy

    OFFICE BUILDING • 1,232 SF
    Value Estimation by Request
    572 Sea Is Pkwy, Saint Helena Island, SC 29920-4205
    View details
    18 Dr Martin Luther King Dr

    18 Dr Martin Luther King Dr

    COMMERCIAL (GENERAL) • 5,600 SF
    Value Estimation
    $615,000
    18 Dr Martin Luther King Dr, Saint Helena Island, SC 29920-5300
    View details

    Saint Helena Island, SC Commercial Real Estate Investment Opportunities Market Analysis

    Explore 155 commercial real estate investment opportunities in Saint Helena Island, SC with 87 listings featured on our commercial real estate marketplace. The current inventory includes 23,278,114 square feet of properties with an estimated value of $56,296,798.

    Estimated prices for commercial real estate in Saint Helena Island, SC begin at $39,000, with an average of $562,967 and extend to $26,255,000.

    In Saint Helena Island, SC, current investment values show:

    • Land positioned at $288,873
    • Residential land & home lots measuring $229,857
    • Other commercial real estate assessed at $188,333
    • Retail properties calculated at $424,166
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    Browse Commercial real estate for Sale Near Saint Helena Island, SC

    Popular Searches in Saint Helena Island, SC

    Most Searched ZIP Codes in Saint Helena Island, SC

    • 29920

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