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    Colleton County, SC Commercial Real Estate for Sale

    140 results
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    Walterboro Commercial Building For Sale
    Contact for pricing
    6,000 SF

    Walterboro Commercial Building For Sale

    1177 Sniders Hwy, Walterboro, SC 29488

    6,000 SF commercial building on 1 acre near I-95.

    • Prime location just off I‑95 with high visibility and traffic.
    • Large 1‑acre parcel with 70+ parking spaces.
    • Highly visible pylon signage and available highway exit signage.
    • Flexible, tenant‑focused lease terms.
    • Suitable for a wide range of uses: commercial, flex, retail, and more.
    Updated: Feb 16
    View details
    Highway 17 Commercial Land Opportunity
    $550,000
    14.00 Acres

    Highway 17 Commercial Land Opportunity

    1 Ace Basin Hwy, Jacksonboro, SC 29452

    14 acres of commercial land with high visibility.

    • High visibility location on Hwy 17, a major North‑South 4‑lane highway.
    • Potential for commercial rezoning with a business site plan.
    • Currently zoned Ag for a lower tax rate.
    • Located between Charleston, Beaufort, and Savannah.
    • Property is in Colleton County.
    Updated: Dec 29, 2025
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    Edisto Island Estate Land
    $499,000
    2.97 Acres

    Edisto Island Estate Land

    Rare 3-acre estate overlooking Bailey Creek marshes on Edisto Island.

    8356 Crooked Creek Ln, Edisto Island, SC 29438
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    Walterboro Land Near I-95
    $445,000
    143.00 Acres

    Walterboro Land Near I-95

    143-acre wooded and wetland tract near I-95.

    I95 & Evergreen Ln, Walterboro, SC 29488
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    7-Acre Walterboro Land Parcel
    $400,000
    7.00 Acres

    7-Acre Walterboro Land Parcel

    7-acre property near I-95, ideal for residential or multi-family development.

    Bells Hwy & Jones Swamp Hwy, Walterboro, SC 29488
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    Cottageville Acreage: Build Your Vision
    $148,900
    10.20 Acres

    Cottageville Acreage: Build Your Vision

    10.2 acres near Cottageville, SC, ideal for homesite or expansion.

    Bama Rd, Cottageville, SC 29435
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    Edisto Deep Water Lot
    $1,195,000
    0.97 Acres

    Edisto Deep Water Lot

    0.97 acre deep water lot in Edisto, South Carolina.

    83 Cocktail Ln, Edisto, SC 29438
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    Dock Slip at Edisto Beach
    $275,000
    0.01 Acres

    Dock Slip at Edisto Beach

    Deep water dock slip for sale at Edisto Beach.

    3702 Docksite Rd, Edisto Beach, SC 29438
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    44 Acres Old Homestead Land
    $313,600
    44.80 Acres

    44 Acres Old Homestead Land

    44 acres of land ideal for a new homestead.

    155 Yamacraw Dr, Smoaks, SC 29481
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    Colleton County Agricultural Land
    $5,334,000
    426.72 Acres

    Colleton County Agricultural Land

    Investment-grade agricultural land with recreational opportunities near I-95.

    565 Hidden Lk, Walterboro, SC 29488
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    56 Acres of Pine Trees
    $420,000
    56.00 Acres

    56 Acres of Pine Trees

    56 acres in Islandton, SC, planted with pine trees.

    Varnadoe Rd, Islandton, SC 29929
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    56 Acres of Pine Trees
    $420,000
    56.00 Acres

    56 Acres of Pine Trees

    56 acres of land planted with pine trees near Walterboro.

    Varnadoe Rd, Islandton, SC 29929
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    56.95 Acres Hunting/Development Land
    $398,650
    56.95 Acres

    56.95 Acres Hunting/Development Land

    56.95 acres of land suitable for hunting or development.

    Lowcountry Hwy, Smoaks, SC 29481
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    47.1 Acres Hunting/Development Opportunity
    $329,700
    47.10 Acres

    47.1 Acres Hunting/Development Opportunity

    47.1 acres of land suitable for hunting or future development.

    Garris Hill Loop, Smoaks, SC 29481
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    Versatile Cottageville Land Opportunity
    $349,000
    31.30 Acres

    Versatile Cottageville Land Opportunity

    31.3 acres in Cottageville, SC, ideal for recreation or development.

    Rutinbuck Ln, Cottageville, SC 29435
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    Walterboro Land with Utilities
    $125,000
    3.00 Acres

    Walterboro Land with Utilities

    3-acre Walterboro land with well, septic, and electrical hookup.

    1509 Mount Carmel Rd, Walterboro, SC 29488
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    Ruffin, SC Recreational Investment Tract
    $1,200,000
    410.00 Acres

    Ruffin, SC Recreational Investment Tract

    410-acre recreational and investment tract in Colleton County, SC.

    Lowcountry Hwy, Ruffin, SC 29475
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    Lowcountry Land in Jacksonboro, SC
    $100,000
    11.00 Acres

    Lowcountry Land in Jacksonboro, SC

    10.98 acres of raw land perfect for estate or retreat.

    1718 Hope Plantation Ln, Jacksonboro, SC 29452
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    Edisto Island Land Opportunity
    $175,000
    10.00 Acres

    Edisto Island Land Opportunity

    10 acres near the beach with no restrictions.

    1068 Sarah Battle Ln, Edisto Island, SC 29438
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    5-Acre Agricultural Land Parcel
    $99,000
    5.00 Acres

    5-Acre Agricultural Land Parcel

    5-acre agricultural land with highway frontage in Cottageville, SC.

    Cottageville Hwy, Cottageville, SC 29435
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    Commercial Land I-95 Access
    $1,100,000

    Commercial Land I-95 Access

    5.40 acre commercial land with I-95 access.

    98 Ladson St, Walterboro, SC 29488
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    Interstate 95 Development Opportunity
    Contact for pricing

    Interstate 95 Development Opportunity

    Infill development site with high visibility and traffic volume.

    & I-95 Bells Hwy, Walterboro, SC 29488
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    Prime Land Near I-95
    $1,500,000

    Prime Land Near I-95

    4-acre commercial land parcel near I-95 and Walmart.

    2222 Bells Hwy, Walterboro, SC 29488
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    Freestanding Retail Building in Walterboro
    $600,000
    14 SF

    Freestanding Retail Building in Walterboro

    14,148 SF retail building with bar and kitchen.

    226 Wichman St, Walterboro, SC 29488
    View details

    Colleton County, SC Commercial Real Estate Investment Opportunities Market Analysis

    Explore 49 commercial real estate for sale in Colleton County, SC, showcased through 140 active listings on our real estate platform. These investment opportunities span a total of 63,852,426 square feet of properties for sale, with an estimated market value of $15,112,250.

    Sale prices for business properties in Colleton County, SC start at $74,000, averaging $559,712, and reaching up to $5,334,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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