Colleton County, SC Commercial real estate for sale

Updated: May 7

Commercial Land with Existing Structures

674 Sniders Highway, Walterboro, SC 29488

$395,000

2.00 AC lot

Exceptional commercial potential on 2 acres with outstanding road frontage.
Four existing structures: office building, church, and two residential homes.
Office building, church, and one home offer valuable road frontage and visibility.
Versatile layout suitable for retail, offices, or mixed‑use development.
Excellent renovation or redevelopment potential for both residential homes.

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Updated: Aug 27

Working Cattle Ranch With Infrastructure

1647 Smoak Road, Walterboro, SC 29488

$1,600,000

201.24 AC lot

201.24 acres across three adjoining parcels
More than 50 acres fenced into four individual paddocks
Approximately 3,000 feet of underground water piping with multiple spigots
3‑acre homesite clearing with deep well and underground electrical service
30' x 48' covered pole‑barn/carport‑style structure and RV site

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Industrial Land Parcel with Road Frontage

Ace Basin Parkway, Green Pond, SC 29446

$500,000

8.75 AC lot

Industrial-zoned corner lot with 700+ feet of road frontage, cleared and described as shovel-ready for future development.

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Single-Tenant Government-Leased Office Building

531 Robertson Blvd, Walterboro, SC 29488

$1,865,000

7,968 sqft 1.23 AC lot

Single-story office asset occupied by a federal government tenant under an existing lease.

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Commercial Land with Utilities

6263 Jefferies Highway, Walterboro, SC 29488

$350,000

2.10 AC lot

Two commercial parcels with on-site utilities and convenient Interstate 26 access.

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Commercial Kitchen Facility with Event Features

113 Santee Lane, Walterboro, SC 29488

$1,000,000

Former hospitality venue includes substantial food-service infrastructure and covered outdoor space.

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Edisto Island Land Opportunity

1068 Sarah Battle Lane, Edisto Island, SC 29438

$174,999

10.00 AC lot

10 acres of unrestricted land near the beach.

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Two-Lot Commercial Land Offering

6263 Jefferies Highway, Walterboro, SC 29488

$350,000

91,476 sqft

Two commercial parcels offer on-site utilities and convenient access to Interstate 26.

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Agricultural Land Tract for Homesite

Bama Road, Cottageville, SC 29435

$129,900

10.20 AC lot

10.2 acres zoned agricultural near Cottageville, suitable for a stick-built or manufactured home, subject to well and septic.

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Commercial Land with Dual Street Access

1011 S Jefferies Boulevard, Walterboro, SC 29488

$80,000

0.53 AC lot

Vacant, commercially zoned land with access from two streets near downtown Walterboro.

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Retail Storefront Building

2048 Bells Hwy, Walterboro, SC 29488

Contact for pricing

3,642 sqft 0.63 AC lot

Retail building positioned within an established commercial corridor serving Walterboro and Colleton County.

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Country Homesite with Mini-Farm Potential

Little Elbow Drive, Walterboro, SC 29488

$99,000

3.00 AC lot

3-acre homesite in Colleton County suitable for a stick-built home or mobile home, with room for farm animals.

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Versatile Acreage in Colleton County

Adnah Church Road, Islandton, SC 29929

$85,000

9.20 AC lot

9.2 acres ideal for building, agriculture, or homesteading.

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Historic Downtown Retail-Office Building

501 E Washington Street, Walterboro, SC 29488

Contact for pricing

1,303 sqft

A flexible storefront building in historic downtown with full bath, kitchen, and private 4-car side parking.

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44 Acres Old Homestead Land

155 Yamacraw Drive, Smoaks, SC 29481

$313,600

44.80 AC lot

44 acres of land ideal for a new homestead.

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Walterboro Land with Utilities

1509 Mt Carmel Road, Walterboro, SC 29488

$125,000

3.00 AC lot

3-acre Walterboro land with well, septic, and electrical hookup.

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Interstate Corridor Industrial Land

1245 Sniders Hwy, Walterboro, SC 29488

$2,201,000

4.20 AC lot

Zoned IICD land with direct access to I-95 and prominent visibility near Exit 53.

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5-Acre Agricultural Land Parcel

Cottageville Highway, Cottageville, SC 29435

$89,999

5.00 AC lot

5-acre agricultural land with highway frontage in Cottageville, SC.

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Single-Story Retail Space

11321 Jefferies Hwy, Walterboro, SC 29488

Contact for pricing

1,865 sqft 0.70 AC lot

Commercial building with highway access on general commercial-zoned land in a regional retail corridor.

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Recreational Farmland Tract

0 A Mt Carmel Road, Walterboro, SC 29488

$399,000

30.70 AC lot

A 30-acre tract with no HOA, suited for equestrian, hunting, or private Lowcountry living near Walterboro.

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Industrial Land Near I-95 Exit

593 Brunson Ln, Walterboro, SC 29488

$1,165,000

11.37 AC lot

Industrial land zoned LI with onsite storage, positioned directly off I-95 at Exit 62 for trucking and manufacturing uses.

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Pine-Planted Hunting Land

Varnadoe Road, Islandton, SC 29929

$336,000

56.00 AC lot

Fully planted pine hunting land on the outskirts of Walterboro and Hampton.

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Flex Building with Showroom

303 Robertson Blvd, Walterboro, SC 29488

$2,950,000

Showroom and warehouse areas are paired with a loading dock, signage, and on-site parking.

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Agricultural Land with Pine Trees

Varnadoe Road, Islandton, SC 29929

$336,000

56.00 AC lot

56-acre agricultural parcel fully planted with pine trees, suited for hunting, farming, or building.

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Colleton County, SC Commercial Real Estate Market Trends and Statistics

Explore 72 commercial real estate for sale in Colleton County, SC, showcased through 70 active listings on our real estate platform. These investment opportunities span a total of 213,628 square feet of properties for sale, with an estimated market value of $36,955,997.

Sale prices for business properties in Colleton County, SC start at $39,000, averaging $724,627, and reaching up to $5,334,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.