Natchez, MS Commercial real estate for Rent & Lease

$1,500 / Mo

1,100 SF

Natchez Office Space For Rent

151 Jefferson Davis Blvd, Natchez, MS 39120

Commercial office space suitable for medical, wellness, or professional use.

Prime location in a highly sought‑after area of Natchez, MS.
Move‑in ready condition, ideal for immediate occupancy.
Well‑designed layout featuring five private exam/office rooms.
Suitable for medical, wellness, or professional services.
Includes a large waiting area and dedicated reception space.

Updated: Aug 21, 2025

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$1,250 / Mo

950 SF

Natchez Office Space For Rent

151 Jefferson Davis Blvd, Natchez, MS 39120

950 sq ft office space in Natchez, Mississippi.

All utilities included in the rental rate.
Well‑located office space in a desirable area of Natchez.
Ample on‑site parking.
950 sq. ft. unit ideal for professional use.
Easy access to local businesses, dining, and services.

Updated: Aug 21, 2025

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$4,000 / Mo

4,000 SF

Retail Space in Natchez, MS

4,000 sq ft retail space for rent in Natchez.

414 Highway 61 N, Natchez, MS 39120

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$1,200 / Mo

1,000 SF

Downtown Natchez Office Space Available

Recently renovated office space for lease in downtown Natchez.

104 S Wall St, Natchez, MS 39120

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$4,500 / Mo

10,000 SF

Versatile Commercial Space in Natchez

10,000 sq ft commercial space suitable for various businesses.

29 Sgt Prentiss Dr, Natchez, MS 39120

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$2,500 / Mo

4,000 SF

Retail Space in Natchez, MS

4,000 SF retail space suitable for various commercial uses.

29 Seargent Prentiss Dr, Natchez, MS 39120

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43,560 SF

Natchez Retail Pad - Prime Location

High-traffic retail pad, build-to-suit option.

261 Devereux Dr, Natchez, MS 39120

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$20 SF/Yr

3,080 SF

Class A Medical Office Natchez

Prime Natchez medical office space available.

46 Sgt Prentiss Dr, Natchez, MS 39120

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$20 SF/Yr

3,080 SF

Medical Office Shell Space

3,080 SF shell space in Class A medical office.

46 Sgt Prentiss Pkwy, Natchez, MS

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Retail Building on Sargent Prentiss

5,343 SF retail building with high traffic visibility.

26 Sargent Prentiss Dr, Natchez, MS 39120

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3,500 SF

Retail Space in Natchez Mall

Retail space available in established Natchez Mall.

350 John Junkin Dr, Natchez, MS

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Based on your search, we've compiled 37 Potential Opportunities for your consideration. Besides 11 Active listings in Natchez, MS, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 22 Properties for Sales.

Explore Commercial Real Estate for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

$23 SF/Yr

12,000 SF

Medical Plaza Office Space Available

Up to 12,000 SF available in medical plaza.

107 Front St, Vidalia, LA 71373

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$1,300 / Mo

1,880 SF

Vidalia Office Space For Rent

Office space in Vidalia, LA, suitable for professional offices.

309 Texas St, Vidalia, LA 71373

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Contact for pricing

2,667 SF

Brookhaven Retail Space Available

Retail space available for lease in Brookhaven, Mississippi.

830-844 Brookway Blvd, Brookhaven, MS 39601

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$2,500 / Mo

1,300 SF

Renovated Medical Clinic Ready-to-Use

Modern, updated medical space with patient rooms and dedicated lab.

301c Highway 51 S, Brookhaven, MS 39601

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Explore Similar Spaces for Sale in Natchez, MS

Consider Similar Space for Sale. We found 22 Spaces in Nearby Locations matching your search parameters.

$199,000

1,720 SF

Turn-Key Automotive Detail Shop

Automotive detail shop with equipment in Natchez, Mississippi.

1169 Dr, Natchez, MS 39120

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$475,000

3,744 SF

Historic Kings Tavern Building

Three-level antebellum structure in Natchez, suitable for restaurant/retail.

613 Jefferson St, Natchez, MS 39120

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$375,000

6,780 SF

Natchez Commercial Building For Sale

Commercial building in high-visibility area with reliable tenants.

55 E Franklin St, Natchez, MS 39120

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$6,900,000

3,529 SF

Turnkey Car Wash Package Sale

Two car wash locations offered as a package deal.

273 John R Junkin Dr, Natchez, MS 39120

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$330,000

4,583 SF

Natchez Medical Facility For Sale

Over 4,500 SF commercial building in Natchez, Mississippi.

500 N Martin Luther King St, Natchez, MS 39120

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1,600 SF

Versatile Commercial Space in Natchez

Adaptable 1,600 sq ft space suitable for various businesses.

151 Jefferson Davis Blvd, Natchez, MS 39120

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$225,000

3,750 SF

Commercial Building with Potential Uses

Commercial building with potential for various uses in Natchez, MS.

335 Lower Woodville Rd, Natchez, MS 39120

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$205,000

2,450 SF

Natchez Commercial Property For Sale

Commercial property featuring offices and a large warehouse area.

235 Highway 61, Natchez, MS 39120

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$850,000

38,600 SF

Natchez Commercial Property For Sale

Commercial property with high visibility and good access for sale.

260 Sgt Prentiss Dr, Natchez, MS 39120

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$525,000

3,500 SF

Two Natchez Office Buildings

Two office buildings on 0.51 acres in Natchez, MS.

255 Highway 61, Natchez, MS 39120

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$185,000

2,190 SF

Natchez Commercial Building For Sale

Well-located commercial building suitable for various uses in Natchez, MS.

245 Highway 61, Natchez, MS 39120

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Family Dollar NNN Investment Opportunity

$1,022,272

8,320 SF

Family Dollar NNN Investment Opportunity

NNN leased Family Dollar with rental increases and zero responsibilities.

1196 N Doctor M.l.k. Jr St, Natchez, MS

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$56,500

500 SF

Natchez Commercial Building For Sale

Commercial building in Natchez, MS, suitable for restaurant or retail.

12 Fourth St, Natchez, MS 39120

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Natchez, MS Commercial Real Estate Leasing Opportunities Market Analysis

Explore Commercial Real Estate leasing options in Natchez, MS with 33 listings featured on our commercial real estate exchange. The current inventory includes 1,185,267,600 square feet of properties with an estimated lease value of $112 SF/Yr.

Estimated lease rates for Commercial Real Estate in Natchez, MS begin at $5 SF/Yr, with an average of $14 SF/Yr and extend to $20 SF/Yr.

In Natchez, MS, current lease rates show:

Office Properties & Spaces positioned at $17
Office space measuring $16
Individual retail properties assessed at $8
Medical offices calculated at $19

Natchez, MS Commercial Real Estate for Lease

Natchez Office Space For Rent

Commercial office space suitable for medical, wellness, or professional use.

Natchez Office Space For Rent

950 sq ft office space in Natchez, Mississippi.

Retail Space in Natchez, MS

Downtown Natchez Office Space Available

Versatile Commercial Space in Natchez

Retail Space in Natchez, MS

Natchez Retail Pad - Prime Location

Class A Medical Office Natchez

Medical Office Shell Space

Retail Building on Sargent Prentiss

Retail Space in Natchez Mall

Explore Commercial Real Estate for Lease in Nearby Cities

Medical Plaza Office Space Available

Vidalia Office Space For Rent

Brookhaven Retail Space Available

Renovated Medical Clinic Ready-to-Use

Explore Similar Spaces for Sale in Natchez, MS

Turn-Key Automotive Detail Shop

Historic Kings Tavern Building

Natchez Commercial Building For Sale

Turnkey Car Wash Package Sale

Natchez Medical Facility For Sale

Versatile Commercial Space in Natchez

Commercial Building with Potential Uses

Natchez Commercial Property For Sale

Natchez Commercial Property For Sale

Two Natchez Office Buildings

Natchez Commercial Building For Sale

Family Dollar NNN Investment Opportunity

Natchez Commercial Building For Sale

Natchez, MS Commercial Real Estate Leasing Opportunities Market Analysis

In Natchez, MS, current lease rates show:

Popular Searches in Natchez, MS

Most Searched ZIP Codes in Natchez, MS

Natchez, MS Commercial Real Estate for Lease

Natchez Office Space For Rent

Commercial office space suitable for medical, wellness, or professional use.

Natchez Office Space For Rent

950 sq ft office space in Natchez, Mississippi.

Retail Space in Natchez, MS

Downtown Natchez Office Space Available

Versatile Commercial Space in Natchez

Retail Space in Natchez, MS

Natchez Retail Pad - Prime Location

Class A Medical Office Natchez

Medical Office Shell Space

Retail Building on Sargent Prentiss

Retail Space in Natchez Mall

Explore Commercial Real Estate for Lease in Nearby Cities

Medical Plaza Office Space Available

Vidalia Office Space For Rent

Brookhaven Retail Space Available

Renovated Medical Clinic Ready-to-Use

Explore Similar Spaces for Sale in Natchez, MS

Turn-Key Automotive Detail Shop

Historic Kings Tavern Building

Natchez Commercial Building For Sale

Turnkey Car Wash Package Sale

Natchez Medical Facility For Sale

Versatile Commercial Space in Natchez

Commercial Building with Potential Uses

Natchez Commercial Property For Sale

Natchez Commercial Property For Sale

Two Natchez Office Buildings

Natchez Commercial Building For Sale

Family Dollar NNN Investment Opportunity

Natchez Commercial Building For Sale

Natchez, MS Commercial Real Estate Leasing Opportunities Market Analysis

In Natchez, MS, current lease rates show:

Popular Searches in Natchez, MS

Most Searched ZIP Codes in Natchez, MS

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