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    Desoto County, MS Commercial Real Estate for Lease

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    Jackson, MS Ridgeland, MS Hattiesburg, MS
    115 results
    Retail/Office Space For Lease
    $1,000/Mo
    900 SF

    Retail/Office Space For Lease

    7122 N Hwy 301, Horn Lake, MS 38637

    Multi-tenant retail/office space available in Horn Lake, MS.

    • High‑visibility location at the NE corner of MS Highway 302 and MS Hwy 301, with significant traffic flow.
    • Move‑in ready 900sf +/- space with updated paint, LVP floors, and new HVAC, furnace, and roof.
    • Plumbing already in place for salon wash basins and sink, suitable for salon or similar business.
    • Ample front door parking and covered walkway for convenient customer access.
    • Part of Lily Plaza Commercial Center with a diverse mix of retail, restaurant, and convenience store tenants.
    Updated: Feb 3
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    Hernando Commercial Space For Lease
    $18 SF/Yr
    1,800 SF

    Hernando Commercial Space For Lease

    341 Wheeler Road, Hernando, MS 38632

    1,800 SF commercial bay on Hwy 51, Hernando, MS.

    • High‑traffic location on Hwy 51 with excellent visibility.
    • Located in Hernando, one of the fastest‑growing towns in North Mississippi.
    • 1,800 SF commercial bay suitable for retail, office, or service businesses.
    • Connected to a busy gas station, providing a built‑in customer base.
    • Ample shared parking available for tenants and customers.
    Updated: Sep 4, 2025
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    Olive Branch Commercial Space Available
    $3,150/Mo
    1,260 SF

    Olive Branch Commercial Space Available

    1,260 SF commercial space in high-traffic Olive Branch location.

    10680 Goodman Road, Olive Branch, MS 38654
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    Retail Space in Bullfrog Center
    $17 SF/Yr
    1,200 SF

    Retail Space in Bullfrog Center

    1200 SF retail space in busy shopping center.

    1415 Goodman Road West, Horn Lake, MS 38637
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    New Retail Space in Horn Lake
    $2,500/Mo
    1,271 SF

    New Retail Space in Horn Lake

    New retail/commercial space with high visibility, built in 2025.

    6100 Horn Lake Road lot: Bay 6, Horn Lake, MS 38637
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    New Retail Space in Horn Lake
    $2,500/Mo
    1,271 SF

    New Retail Space in Horn Lake

    New retail/commercial space with high visibility, built in 2025.

    6100 Horn Lake Road lot: Bay 4, Horn Lake, MS 38637
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    New Retail Space in Horn Lake
    $2,500/Mo
    1,271 SF

    New Retail Space in Horn Lake

    New retail/commercial space with high visibility and traffic.

    6100 Horn Lake Road lot: Bay 7, Horn Lake, MS 38637
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    New Retail Space in Horn Lake
    $2,500/Mo
    1,255 SF

    New Retail Space in Horn Lake

    New retail/commercial space with high visibility and traffic.

    6100 Horn Lake Road lot: Bay 8, Horn Lake, MS 38637
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    New Retail Space in Horn Lake
    $2,500/Mo
    1,271 SF

    New Retail Space in Horn Lake

    New retail/commercial space with high visibility and traffic.

    6100 Horn Lake Road lot: Bay 2, Horn Lake, MS 38637
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    New Retail Space in Horn Lake
    $2,500/Mo
    1,271 SF

    New Retail Space in Horn Lake

    New retail/commercial space in high-visibility location, built in 2025.

    6100 Horn Lake Road lot: Bay 1, Horn Lake, MS 38637
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    New Retail Space in Horn Lake
    $2,500/Mo
    1,271 SF

    New Retail Space in Horn Lake

    New retail/commercial space with high visibility and traffic.

    6100 Horn Lake Road lot: Bay 3, Horn Lake, MS 38637
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    New Retail Space in Horn Lake
    $2,500/Mo
    1,271 SF

    New Retail Space in Horn Lake

    New retail/commercial space with high visibility and traffic.

    6100 Horn Lake Road lot: Bay 5, Horn Lake, MS 38637
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    Southaven Retail and Restaurant Spaces
    Contact for pricing
    324,801 SF

    Southaven Retail and Restaurant Spaces

    Upscale outlet center with retail and restaurant spaces for lease.

    5205 Airways Blvd, Southaven, MS 38671
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    Retail Space in Stateline Square
    $7 SF/Yr

    Retail Space in Stateline Square

    Prime retail location off Interstate 55 in Southaven, MS.

    550 Stateline Road, Southaven, MS 38671
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    Prime Retail/Office Space Available
    Contact for pricing
    1,200 SF

    Prime Retail/Office Space Available

    Turn-key office space near major tenants, high visibility location.

    521 Stateline Road, Southaven, MS 38671
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    Retail Space Near Interstate 55
    Contact for pricing
    1,998 SF

    Retail Space Near Interstate 55

    Retail space available in Hernando, Mississippi, near I-55.

    2631 McIngvale Road, Hernando, MS 38632
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    Medical Office Park Near I-55
    $19 SF/Yr
    1,206 SF

    Medical Office Park Near I-55

    Medical office space for lease near Baptist DeSoto Hospital.

    7900 Airways Boulevard, Southaven, MS 38671
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    Modern Office Space in Olive Branch
    $12 SF/Yr

    Modern Office Space in Olive Branch

    Premier office property with customizable floor plans and modern amenities.

    8804 Caroma Street, Olive Branch, MS 38654
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    240,000 SF Warehouse For Lease
    $4 SF/Yr
    240,000 SF

    240,000 SF Warehouse For Lease

    Warehouse for lease in DeSoto County with expansion potential.

    8950 Hacks Cross Rd, Olive Branch, MS 38654
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    Retail Space Near High Traffic
    $12 SF/Yr
    27,540 SF

    Retail Space Near High Traffic

    Retail space available near Hacks Cross Rd and Goodman Rd.

    7685-7721 Hacks Cross Rd, Olive Branch, MS 38654
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    Southaven Shopping Center Retail Space
    Contact for pricing
    1,776 SF

    Southaven Shopping Center Retail Space

    Retail spaces available in a busy Southaven shopping center.

    775-975 Goodman Rd E, Southaven, MS 38671
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    Customizable Commercial Space Available
    Contact for pricing
    6,000 SF

    Customizable Commercial Space Available

    6,000 +/- SF customizable space for rent.

    1177 Nesbit Drive, Nesbit, MS 38651
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    Industrial Space For Lease
    $5 SF/Yr
    140,400 SF

    Industrial Space For Lease

    140,400 SF industrial space available for lease.

    6332 Commercial Dr, Olive Branch, MS 38654
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    Desoto 55 Logistics Center
    Contact for pricing
    99,978 SF

    Desoto 55 Logistics Center

    Regional distribution center with easy access to sorting hubs.

    1222 Commerce Parkway, Horn Lake, MS 38637
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    Desoto County, MS Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in Desoto County, MS with 115 listings featured on our commercial real estate exchange. The current inventory includes 734,795 square feet of properties with an estimated lease value of $714 /Mo.

    Estimated lease rates for Commercial real estate in Desoto County, MS begin at $4 SF/Yr, with an average of $22 SF/Yr and extend to $180 SF/Yr.
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