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    Natick, MA Commercial Real Estate for Lease

    50 results
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    Natick Center Office Suite
    $19 SF/Yr
    3,705 SF

    Natick Center Office Suite

    34 Main St #3, Natick, MA 1760

    Sub-leasable office suite in Natick Center with collaborative workspace.

    • Excellent location in desirable Natick Center, walking distance to shops, restaurants, and public transportation.
    • Opportunity to sub‑lease until 3/31/2027, or longer directly with landlord.
    • Elevator building for easy access.
    • Mix of private offices and open collaborative workspace.
    • Suite includes a kitchenette and two bathrooms.
    Updated: Dec 14, 2025
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    Retail Space Near Natick Mall
    $38 SF/Yr
    3,775 SF

    Retail Space Near Natick Mall

    321 Speen St, Natick, MA 1760

    3,775 SF retail space with salon and spa.

    • High‑traffic location across from Natick Mall
    • Located in a high‑performing shopping plaza with established tenants including Aldi, Total Wine, Guitar Center, Ethan Allen, and Burlington Coat Factory
    • Fully equipped salon with 10 chairs, 3 wash bowls, and a color room
    • Features a spa with 6 rooms, a lounge, and 2 bathrooms with lockers
    • Large retail space with 3,775 SF
    Updated: Nov 21, 2025
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    Natick Office/Medical Space Available
    Contact for pricing
    2,275 SF

    Natick Office/Medical Space Available

    Office/medical space for lease in Natick, Massachusetts.

    67 Union Street, Natick, MA 1760
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    Natick Center Retail Space Available
    $20 SF/Yr
    10,200 SF

    Natick Center Retail Space Available

    Spacious retail space in historic Natick Center, potential for restaurant.

    25 Main St, Natick, MA 1760
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    Landmark Building in Downtown Natick
    Contact for pricing

    Landmark Building in Downtown Natick

    Prime retail and office spaces in a signature building.

    2 Summer Street, Natick, MA 1760
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    Retail, Medical, Office Space Available
    Contact for pricing
    8,920 SF

    Retail, Medical, Office Space Available

    First floor retail, medical, and office space for lease.

    69 East Central Street, Natick, MA 1760
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    Two Standalone Office Buildings For Rent
    $6,000 /Mo

    Two Standalone Office Buildings For Rent

    Two office buildings on a corner lot available for lease.

    180 W Central Street, Natick, MA 1760
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    Natick Office Space for Lease
    Contact for pricing
    27,000 SF

    Natick Office Space for Lease

    2,090 SF office space in a renovated building.

    5 Commonwealth Road, Natick, MA 1760
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    Prime Natick Commercial Space
    Contact for pricing

    Prime Natick Commercial Space

    Modern flex space near West Natick train stop.

    245 W Central St, Natick, MA 1760
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    Natick Medical Office Space
    Contact for pricing

    Natick Medical Office Space

    Medical office space available in downtown Natick.

    12 West Central Street, Natick, MA 1760
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    Natick Center Commercial Space Available
    $800 /Mo
    625 SF

    Natick Center Commercial Space Available

    Lower level commercial space in Natick Center, ideal for office.

    31 S Main St #B2, Natick, MA 1760
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    Office/Retail Space on Route 16
    Contact for pricing
    14,281 SF

    Office/Retail Space on Route 16

    1,200 SF office/retail space with street access and visibility.

    57 Eliot Street, Natick, MA 1760
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    Natick Office Space For Rent
    $21 SF/Yr
    7,000 SF

    Natick Office Space For Rent

    7000 SF office space available for immediate occupancy.

    19 Willow St, Natick, MA 1760
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    Natick Office Space For Rent
    $21 SF/Yr
    7,000 SF

    Natick Office Space For Rent

    Office space available immediately in Natick, Massachusetts.

    19 Willow St, Natick, MA
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    Natick Medical Office Space Available
    Contact for pricing
    4,449 SF

    Natick Medical Office Space Available

    First floor medical office space for lease in Natick.

    12 West Central Street, Natick, MA 1760
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    Retail Space in Natick, MA
    Contact for pricing

    Retail Space in Natick, MA

    20,300 SF retail space on 2.8 acres in Natick.

    Natick, MA 01760
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    Freestanding Building with Pylon Signage
    Contact for pricing
    20,000 SF

    Freestanding Building with Pylon Signage

    20,000 SF available in a freestanding building with parking.

    625 Worcester St, Natick, MA 1760
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    Move-in Ready Co-working Office
    $400 /Mo

    Move-in Ready Co-working Office

    Efficient co-working space with utilities included and easy access.

    209 W Central #305, Natick, MA 1760
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    Natick Flex Space Available
    $18 SF/Yr
    4,000 SF

    Natick Flex Space Available

    Single-story office/R&D building in Natick Business Park.

    4 Strathmore Rd, Natick, MA
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    Natick Flex Space Available
    $19 SF/Yr
    6,925 SF

    Natick Flex Space Available

    Flex space for rent, renovated in 2022, walkable to amenities.

    235 W Central St, Natick, MA
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    Natick Office Space Sublease Opportunity
    Contact for pricing
    1,410 SF

    Natick Office Space Sublease Opportunity

    Modern office suites available for sublease in Natick, Massachusetts.

    7-11 Huron Dr, Natick, MA
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    Renovated Office Building with Elevator
    $1,500 /Mo

    Renovated Office Building with Elevator

    Modern office space available for immediate occupancy near downtown.

    4 Mechanic #204-206, Natick, MA 1760
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    Industrial Space Near West Natick
    Contact for pricing
    44,950 SF

    Industrial Space Near West Natick

    Industrial/flex space with modern amenities and convenient access to transportation.

    245 W Central St, Natick, MA 1760
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    Natick Retail Space For Lease
    Contact for pricing
    6,300 SF

    Natick Retail Space For Lease

    Retail spaces available in high-traffic Natick location.

    603 Worcester St, Natick, MA
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    Natick, MA Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in Natick, MA with 50 listings featured on our commercial real estate exchange. The current inventory includes 934,579,800 square feet of properties with an estimated lease value of $115 SF/Yr.

    Estimated lease rates for Commercial real estate in Natick, MA begin at $19 SF/Yr, with an average of $28 SF/Yr and extend to $38 SF/Yr.
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