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    St Lucie County, FL Commercial Real Estate for Lease

    296 results
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    Mixed-Use Property Near Turnpike
    $3,300 / Mo
    1,524 SF

    Mixed-Use Property Near Turnpike

    1892 SW Biltmore St, Port Saint Lucie, FL 34984

    Flexible mixed-use property with residential and commercial potential.

    • Oversized 10,000 SF lot with outstanding flexibility.
    • Ideally located minutes from Florida's Turnpike and I‑95.
    • Suitable for service‑based professionals or outdoor‑oriented businesses.
    • Includes a 3‑bedroom, 2‑bath home adaptable for residence, office, or storage.
    • Recent improvements include a new roof, modern plank tile flooring, and updated kitchen.
    Updated: Jan 17
    View details
    Ocean View Office Suite
    $1,200 / Mo
    4,500 SF

    Ocean View Office Suite

    221 S Ocean Dr, Fort Pierce, FL 34949

    Second-floor office suite with ocean views available for lease.

    • Ocean view office suite
    • Reasonable lease rate for Hutchinson Island location ($1,200/month year 1)
    • New metal roof and impact windows
    • Approximately 1,050 sq ft with entry/conference room + 4 offices + private bathroom
    • Join established businesses (Coldwell Banker, Ryen Marine Insurance Group)
    Updated: Dec 19, 2025
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    Modern Flex Office Spaces Available
    $17 SF/Yr
    1,500 SF

    Modern Flex Office Spaces Available

    Flexible leasing options in a busy industrial corridor.

    3801 Oleander Ave, Fort Pierce, FL 34982
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    Modern Flex Office Spaces Available
    $17 SF/Yr
    1,500 SF

    Modern Flex Office Spaces Available

    Flexible leasing options in modern flex office spaces.

    3801 Oleander Ave, Fort Pierce, FL 34982
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    Modern Flex Office Spaces Available
    $17 SF/Yr
    1,500 SF

    Modern Flex Office Spaces Available

    Modern flex office spaces for lease in Fort Pierce, Florida.

    3801 Oleander Ave, Fort Pierce, FL 34982
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    Modern Flex Office Spaces Available
    $17 SF/Yr
    1,500 SF

    Modern Flex Office Spaces Available

    Modern flex office spaces for lease on busy industrial corridor.

    3801 Oleander Ave, Fort Pierce, FL 34982
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    Modern Flex Office Spaces Available
    $17 SF/Yr
    1,500 SF

    Modern Flex Office Spaces Available

    Versatile flex spaces on a busy industrial corridor.

    3801 Oleander Ave, Fort Pierce, FL 34982
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    Medical Co-working Space Available
    $5,416 / Mo
    63,341 SF

    Medical Co-working Space Available

    Co-working space for medical professionals near major hospitals.

    2401 Frist Blvd, Fort Pierce, FL 34950
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    Versatile Facility in Fort Pierce
    $5,000 / Mo
    4,028 SF

    Versatile Facility in Fort Pierce

    4,028 SF facility ideal for various uses in Fort Pierce.

    2525 S 25Th St, Fort Pierce, FL 34981
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    Fort Pierce Office/Warehouse Opportunity
    $2,200,000
    59,677 SF

    Fort Pierce Office/Warehouse Opportunity

    11,476 sq. ft. Class B office building for rent.

    3030 N 25Th St, Fort Pierce, FL 34946
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    Profitable Office Space with Tenants
    $275,000

    Profitable Office Space with Tenants

    Turnkey office property with long-term tenants and immediate cash flow.

    544 NW University Blvd Blvd, Port Saint Lucie, FL 34986
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    Professional Office Space Available
    $2,287 / Mo
    998 SF

    Professional Office Space Available

    Class A office suite with private offices and open space.

    2100 SE Hillmoor Dr, Port St Lucie, FL 34952
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    Landmark Office Building in Fort Pierce
    $16 SF/Yr
    56,628 SF

    Landmark Office Building in Fort Pierce

    5,400 SF office space available for lease.

    2222 Colonial Rd, Fort Pierce, FL 34950
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    Retail Space in Historic Downtown
    $12 SF/Yr
    10,000 SF

    Retail Space in Historic Downtown

    Prime retail spaces available in historic downtown Fort Pierce.

    0000 2Nd St, Fort Pierce, FL 34950
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    Fort Pierce Office Space Available
    $16 SF/Yr
    18,228 SF

    Fort Pierce Office Space Available

    2,400 SF office space for lease in Fort Pierce.

    2222 Colonial Rd, Fort Pierce, FL 34950
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    Medical Office Near Lawnwood Hospital
    $500,000

    Medical Office Near Lawnwood Hospital

    Turnkey medical office space in Fort Pierce healthcare corridor.

    1801 S 23Rd St, Fort Pierce, FL 34950
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    Freestanding Building on US Highway
    $26 SF/Yr
    46,609 SF

    Freestanding Building on US Highway

    General Commercial zoning ideal for retail, medical, or restaurant.

    10244 S Us Highway 1, Port St Lucie, FL 34952
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    Medical Office Space For Rent
    $24 SF/Yr
    998 SF

    Medical Office Space For Rent

    Updated medical office space available for rent in Port St. Lucie.

    1801 SE Hillmoor Dr, Port St Lucie, FL 34952
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    Port Saint Lucie Retail Opportunity
    $60,000
    15,894 SF

    Port Saint Lucie Retail Opportunity

    Retail space available in Port Saint Lucie, Florida.

    7991 S Us Highway 1, Fort Pierce, FL 34952
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    Fort Pierce Retail Investment Opportunity
    $275,000
    1,155 SF

    Fort Pierce Retail Investment Opportunity

    Commercial property with high visibility, convenient access, and redevelopment potential.

    1901 Orange Ave, Fort Pierce, FL 34950
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    Salon Suite in Port St. Lucie
    $3,500 / Mo
    125,884 SF

    Salon Suite in Port St. Lucie

    Turn-key salon suite in a busy plaza.

    302 SW Tulip Blvd, Port St Lucie, FL 34953
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    Port St. Lucie Executive Office
    $1,527 / Mo
    998 SF

    Port St. Lucie Executive Office

    Executive office suite in Port St. Lucie medical corridor.

    2100 SE Hillmoor Dr, Port St Lucie, FL 34952
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    Versatile Commercial Property with Residence
    $2,800 / Mo
    1,524 SF

    Versatile Commercial Property with Residence

    Commercial property with residence near Florida's Turnpike and I-95.

    481 SW Voltair Ter, Port Saint Lucie, FL 34984
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    Fort Pierce Office/Warehouse Space
    $10,000 / Mo
    4,648 SF

    Fort Pierce Office/Warehouse Space

    Versatile commercial property on US 1 with high visibility.

    3535 Old Dixie Hwy, Fort Pierce, FL 34946
    View details

    St Lucie County, FL Commercial Real Estate Leasing Opportunities Market Analysis

    Explore Commercial Real Estate leasing options in St Lucie County, FL with 439 listings featured on our commercial real estate exchange. The current inventory includes 120,773,992,906 square feet of properties with an estimated lease value of $235,752.

    Estimated lease rates for Commercial Real Estate in St Lucie County, FL begin at $0.75 SF/Yr, with an average of $1,331 /Mo and extend to $120,000.

    In St Lucie County, FL, current lease rates show:

    • Office Properties & Spaces positioned at $21
    • Retail properties measuring $23
    • Industrial properties assessed at $493
    • Office space calculated at $21
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    Browse Commercial real estate for Lease Near St Lucie, FL

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