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    Freestanding Medical Office Building
    Updated: Aug 3
    Freestanding Medical Office Building

    Port St Lucie, FL

    $3,300,000
    11,187 sqft 1.02 AC lot
    Freestanding medical office building with five medical suites
    Delivered vacant with a fully built‑out professional interior
    49 on‑site parking spaces
    1.02‑acre property directly adjacent to HCA Florida St. Lucie Hospital
    8 out of 10 AC units replaced within the last 5 years
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    Freestanding Duffy’s Sports Grill Restaurant
    Updated: Jul 15
    Freestanding Duffy’s Sports Grill Restaurant

    3001 SW Port St Lucie Blvd, Port Saint Lucie, FL 34953

    $4,580,000
    7,250 sqft 1.38 AC lot
    7,250‑square‑foot freestanding restaurant property
    Built in 2018
    Occupied by Duffy’s Sports Grill
    Reported 7.25% cap rate
    Located on SW Port St. Lucie Blvd. in Port Saint Lucie
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    Medical Office Space with Two Buildings
    Medical Office Space with Two Buildings

    1803 & 1805 S 25th Street, Fort Pierce, FL

    $1,900,000
    9,560 sqft 0.96 AC lot

    Fully occupied medical and office property with central climate control, public utilities, and guest parking.

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    See what stands out in St. Lucie County

    We check every for-sale listing in the county against comparable properties across the country. Most price about where you would expect. A few are worth a second look.

    We check every listing here. A few are worth a second look.

    Cap Rate available after sign in
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    Commercial Building with Left Turn Access
    Commercial Building with Left Turn Access

    1531 Delaware Ave, Fort Pierce, FL 34950

    $699,999
    4,760 sqft 0.71 AC lot

    4,760 SF commercial building on a 0.71-acre lot with left-in/left-out access and C-3 zoning.

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    Freestanding Office Building
    Freestanding Office Building

    706 N 7th Street, Fort Pierce, FL

    $550,000
    4,805 sqft 0.28 AC lot

    CBS office property with private rooms, multiple restrooms, reception areas, and a kitchen.

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    Renovated Flex Space Facility
    Renovated Flex Space Facility

    16050 Orange Avenue, Fort Pierce, FL

    $3,299,000
    14,224 sqft 1.98 AC lot

    Industrial zoning, fenced grounds, covered parking, and a parts counter define the property’s practical commercial setup.

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    Turn a Listing Into an Investment Snapshot Cap Rate, Potential NOI, Demand score for every listing. Go To Analytics Center
    Multi-Tenant Storefront Property
    Multi-Tenant Storefront Property

    110 S US HIGHWAY 1, Fort Pierce, FL

    $850,000
    7,346 sqft 0.18 AC lot

    Four retail tenants occupy a downtown commercial building along US Highway 1 with General Co zoning.

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    Walgreens Drug Store on Signalized Corner
    Walgreens Drug Store on Signalized Corner

    Port St Lucie, FL 34953

    $6,000,000
    13,569 sqft 1.80 AC lot

    Corporate-leased Walgreens on a signalized corner with strong visibility and access along Gatlin Blvd carrying about 58,500 vehicles per day.

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    Established-Tenant Shopping Center
    Established-Tenant Shopping Center

    Port St Lucie, FL

    $7,000,000
    6,204 sqft

    Mixed-use plaza with restaurant, convenience store and gas station, and barbershop tenants serving a residential trade area.

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    Fenced Flex Space with Outdoor Storage
    Fenced Flex Space with Outdoor Storage

    Port St Lucie, FL

    $1,300,000
    2,573 sqft 0.55 AC lot

    LI-CS zoning, two structures, and regional access support varied commercial operations.

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    Free-Standing Medical Office Building
    Free-Standing Medical Office Building

    2624 S Us Highway 1, Fort Pierce, FL 34982

    $990,000
    8,000 sqft 0.50 AC lot

    Free-standing concrete block medical office with reception, waiting area, and eight exam rooms, updated and newly roofed.

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    4-Exam-Room Medical Office
    4-Exam-Room Medical Office

    1801 S 23rd Street, Fort Pierce, FL

    $399,500
    1,734 sqft

    Professional-zoned medical office condo with exam, reception, lab, and private office areas.

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    Renovated Office Condo
    Renovated Office Condo

    725 SE, Port St Lucie, FL

    $160,000
    700 sqft

    Second-floor office suite with a reception area, two private offices, break area, and natural light.

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    Freestanding Restaurant Building
    Freestanding Restaurant Building

    3001 SW, Port St Lucie, FL 34953

    $4,580,000
    7,250 sqft 1.88 AC lot

    Single-unit commercial building occupied by a corporately guaranteed restaurant tenant with 3% annual rent increases.

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    Freestanding Medical Office Building
    Freestanding Medical Office Building

    1900 Nebraska Avenue, Fort Pierce, FL 34950

    $625,000
    2,100 sqft

    Configured for clinical operations with exam rooms, private offices, reception, and patient parking.

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    Freestanding Medical Office Building
    Freestanding Medical Office Building

    3651 Virginia Avenue, Fort Pierce, FL

    $1,695,000
    9,255 sqft 0.69 AC lot

    The property combines private offices, classrooms, and a kitchen with dining space in a dedicated commercial facility.

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    Concrete Block Distribution Facility
    Concrete Block Distribution Facility

    602 S 5th St, Fort Pierce, FL 34950

    $1,595,000
    10,944 sqft

    Warehouse configuration includes office space and dock-high loading.

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    Retail Condo with Road Exposure
    Retail Condo with Road Exposure

    Port St Lucie, FL

    $325,000
    800 sqft

    A concrete-block retail condo with tile flooring, central heating, electric cooling, and public water and sewer.

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    Medical Office Condo with Sale-Leaseback
    Medical Office Condo with Sale-Leaseback

    St Lucie West, FL 34986

    $950,000
    2,818 sqft

    Turn-key medical office condo with in-place practice, structured sale-leaseback for stable, predictable investor cash flow.

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    Corner Storefront Property
    Corner Storefront Property

    2402 S US HWY 1, Fort Pierce, FL 34982

    $1,699,000
    0.51 AC lot

    Existing retail building leased to Tuff Shed under a multi-year net lease.

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    Commercial Land with Restaurant Building
    Commercial Land with Restaurant Building

    13490 Orange Ave, Fort Pierce, FL 34945

    $780,000
    2,836 sqft

    General Commercial-zoned property combines an operating-format restaurant facility with land for additional commercial improvements.

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    Professional Office Building
    Professional Office Building

    756 SE, Port St Lucie, FL

    $799,000
    3,404 sqft 0.50 AC lot

    Standalone commercial building with flexible office configuration, professional zoning, updated air conditioning, and on-site parking.

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    Assisted Living Home with Pool
    Assisted Living Home with Pool

    2150 SW Imperial St, Port St Lucie, FL 34987

    $635,000
    2,864 sqft

    Custom-built CBS pool home operating as a proven home care assisted living business with fenced yard and screened patio.

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    Light Industrial Warehouse
    Light Industrial Warehouse

    415 ANGLE Road, Fort Pierce, FL 34947

    $1,950,000
    8,424 sqft 2.64 AC lot

    Concrete-block industrial facility with drive-in loading and a large supporting land component.

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    St Lucie County, FL Commercial Real Estate Market Trends and Statistics

    Explore 447 commercial real estate for sale in St Lucie County, FL, showcased through 447 active listings on our real estate platform. These investment opportunities span a total of 29,463,407 square feet of properties for sale, with an estimated market value of $547,128,304.

    Sale prices for business properties in St Lucie County, FL start at $30,000, averaging $1,860,980, and reaching up to $26,136,024 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Browse Commercial real estate for Sale Near St Lucie, FL

    Featured St. Lucie County Real Estate Agencies

    Realmo connects you with licensed St. Lucie County CRE brokers providing property specifications, local market pricing, and commercial transaction underwriting support.

    Keller Williams Realty of Port St Lucie
    9700 Reserve Boulevard Fort Pierce, FL 34986
    Phone: 17722365700
    Atlantic Shores Realty Executives
    201 SW Port St Lucie Blvd, Suite 104 Fort Pierce, FL 34984
    Phone: 17722282111
    www.asrefl.com
    Management Specialists
    2355 SE Seafury Lane Fort Pierce, FL 34952
    Phone: 17723809011
    www.mgtspec.com

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