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    St Lucie County, FL Commercial Real Estate for Sale

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    416 properties
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    Office Building with Classroom Layout
    Updated: Oct 7
    Office Building with Classroom Layout

    3651 VIRGINIA Avenue, Fort Pierce, FL

    $1,695,000
    9,255 sqft 0.69 AC lot
    Freestanding office building on Virginia Avenue
    Classrooms, private offices, kitchen, and dining hall
    Built in 2006
    Central heating and central air conditioning
    Public water and public sewer service
    View details
    Freestanding Medical Office with Lanai
    Updated: Sep 20
    Freestanding Medical Office with Lanai

    1505 Orange Avenue, Fort Pierce, FL

    $2,250,000
    9,796 sqft 1.86 AC lot
    1.86‑acre medical office property on Orange Avenue
    Freestanding facility with flexible spaces that can be divided into suites
    Large multipurpose room, food‑preparation kitchen and several bathrooms
    Screened lanai, covered entrance and wooded garden with sidewalks
    One mile from US‑1 and 3.3 miles from I‑95
    View details
    Five-Suite Medical Office Building
    Five-Suite Medical Office Building

    Port St Lucie, FL

    $3,300,000
    11,187 sqft 1.02 AC lot

    Vacant professional space has multiple medical suites and on-site parking, with no association.

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    Commercial Building with Left Turn Access
    Commercial Building with Left Turn Access

    1531 Delaware Ave, Fort Pierce, FL 34950

    $675,000
    4,760 sqft 0.71 AC lot

    4,760 SF commercial building on a 0.71-acre lot with left-in/left-out access and C-3 zoning.

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    Medical Office Space with Two Buildings
    Medical Office Space with Two Buildings

    1803 & 1805 S 25th Street, Fort Pierce, FL

    $1,900,000
    9,560 sqft 0.96 AC lot

    Fully occupied medical and office property with central climate control, public utilities, and guest parking.

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    Freestanding Duffy’s Sports Grill Restaurant
    Freestanding Duffy’s Sports Grill Restaurant

    3001 SW Port St Lucie Blvd, Port Saint Lucie, FL 34953

    $4,580,000
    7,250 sqft 1.38 AC lot

    Established restaurant property with national retail anchors and access to I-95 and Florida’s Turnpike.

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    Self-Storage Property with Apartment
    Self-Storage Property with Apartment

    2772 Harson Way, Fort Pierce, FL

    $175,000
    5,025 sqft 0.48 AC lot

    The 1925 property combines garage and storage space with a separate apartment.

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    Freestanding Office Building
    Freestanding Office Building

    3651 VIRGINIA Avenue, Fort Pierce, FL 34981

    $1,695,000
    8,420 sqft 0.69 AC lot

    CG zoning supports office, educational, retail, and health services uses.

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    Freestanding Office Building
    Freestanding Office Building

    706 N 7th Street, Fort Pierce, FL

    $550,000
    4,805 sqft 0.28 AC lot

    Configured with private offices, multiple reception areas, bathrooms, and a kitchen, the building supports a range of office functions.

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    Renovated Flex Space Facility
    Renovated Flex Space Facility

    16050 Orange Avenue, Fort Pierce, FL

    $3,299,000
    14,224 sqft 1.98 AC lot

    Industrial zoning, fenced grounds, covered parking, and a parts counter define the property’s practical commercial setup.

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    Freestanding Office Building
    Freestanding Office Building

    706 N 7th St, Fort Pierce, FL 34950

    $550,000
    4,691 sqft

    A multi-office layout includes private rooms, separate reception areas, and an on-site kitchen.

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    Multi-Tenant Storefront Property
    Multi-Tenant Storefront Property

    110 S US HIGHWAY 1, Fort Pierce, FL

    $850,000
    7,346 sqft 0.18 AC lot

    Four retail tenants occupy a downtown commercial building along US Highway 1 with General Co zoning.

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    Established-Tenant Shopping Center
    Established-Tenant Shopping Center

    Port St Lucie, FL

    $7,000,000
    6,204 sqft

    Mixed-use plaza with restaurant, convenience store and gas station, and barbershop tenants serving a residential trade area.

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    Walgreens Drug Store on Signalized Corner
    Walgreens Drug Store on Signalized Corner

    Port St Lucie, FL 34953

    $5,700,000
    13,569 sqft 1.80 AC lot

    Corporate-leased Walgreens on a signalized corner with strong visibility and access along Gatlin Blvd carrying about 58,500 vehicles per day.

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    Equipped Restaurant Business
    Equipped Restaurant Business

    2510 S US HIGHWAY 1, Fort Pierce, FL

    $100,000
    1,800 sqft

    The sale includes a commercial kitchen, dining room, fixtures, and related restaurant infrastructure.

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    Commercially Zoned Quadplex
    Commercially Zoned Quadplex

    Fort Pierce, FL 34946

    $600,000
    2,244 sqft 0.42 AC lot

    Current multifamily use includes four apartments along with boat, RV, and warehouse storage.

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    Flex Building with Fenced Yard
    Flex Building with Fenced Yard

    2807 Okeechobee Rd, Fort Pierce, FL 34947

    $1,250,000
    4,100 sqft 0.55 AC lot

    A two-section commercial property pairs enclosed work space with outdoor storage and two permitted sheds.

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    Storefront Property with Warehouse Space
    Storefront Property with Warehouse Space

    221 N US Highway 1, Fort Pierce, FL 34950

    $779,000
    0.25 AC lot

    Showroom, storage areas, and on-site parking support a versatile commercial layout.

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    Freestanding Sports Restaurant
    Freestanding Sports Restaurant

    3001 SW Port Saint Lucie Blvd, Port Saint Lucie, FL 34953

    $4,580,000
    7,250 sqft 1.88 AC lot

    Standalone restaurant property near major national retailers in an established Port Saint Lucie shopping area.

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    4-Exam-Room Medical Office
    4-Exam-Room Medical Office

    1801 S 23rd Street, Fort Pierce, FL

    $399,500
    1,734 sqft

    Professional-zoned medical office condo with exam, reception, lab, and private office areas.

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    Free-Standing Medical Office Building
    Free-Standing Medical Office Building

    2624 S Us Highway 1, Fort Pierce, FL 34982

    $990,000
    8,000 sqft 0.50 AC lot

    Free-standing concrete block medical office with reception, waiting area, and eight exam rooms, updated and newly roofed.

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    Freestanding Medical Office Building
    Freestanding Medical Office Building

    1912 Nebraska Avenue, Fort Pierce, FL 34950

    $625,000
    2,100 sqft

    Two-office medical facility with exam rooms, patient drop-off access, and dedicated parking.

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    Freestanding Restaurant Building
    Freestanding Restaurant Building

    3001 SW, Port St Lucie, FL 34953

    $4,580,000
    7,250 sqft 1.88 AC lot

    Single-unit commercial building occupied by a corporately guaranteed restaurant tenant with 3% annual rent increases.

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    Retail Condo with Road Exposure
    Retail Condo with Road Exposure

    Port St Lucie, FL

    $325,000
    800 sqft

    A concrete-block retail condo with tile flooring, central heating, electric cooling, and public water and sewer.

    View details
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    St Lucie County, FL Commercial Real Estate Market Trends and Statistics

    Explore 416 commercial real estate for sale in St Lucie County, FL, showcased through 416 active listings on our real estate platform. These investment opportunities span a total of 29,322,459 square feet of properties for sale, with an estimated market value of $529,856,953.

    Sale prices for business properties in St Lucie County, FL start at $30,000, averaging $1,872,286, and reaching up to $26,136,024 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Featured St. Lucie County Real Estate Agencies

    Realmo connects you with licensed St. Lucie County CRE brokers providing property specifications, local market pricing, and commercial transaction underwriting support.

    Keller Williams Realty of Port St Lucie
    9700 Reserve Boulevard Fort Pierce, FL 34986
    Phone: (772) 236-5700
    Atlantic Shores Realty Executives
    201 SW Port St Lucie Blvd, Suite 104 Fort Pierce, FL 34984
    Phone: (772) 228-2111
    www.asrefl.com
    Gentile Property Group
    850 S 21st Street, Suite O Fort Pierce, FL 34950
    Phone: (772) 353-6632
    www.sellingstlucie.com
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