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    Mesa County, CO Commercial Real Estate for Lease

    233 results
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    Fruita Medical Office Condo
    $3,054 / Mo
    1,666 SF

    Fruita Medical Office Condo

    455 Kokopelli Blvd, Fruita, CO 81521

    1,666 SF medical office condo in Fruita, Colorado.

    • Well‑suited for outpatient or specialty medical practices with an efficient, patient‑friendly layout.
    • Features five well‑appointed exam rooms equipped with medical chairs, dedicated nurse stations, and a lab.
    • Located in a professional retail/office complex adjacent to Family Health West Primary Care, hotels, and restaurants, providing strong visibility and convenient access.
    • Flexible floor plan allows for smooth patient and staff circulation.
    • Landlord‑approved improvements may be considered, including creating a dedicated reception area.
    Updated: Feb 26
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    Historic Retail Space in Fruita
    $2,700 / Mo
    1,800 SF

    Historic Retail Space in Fruita

    210 E Aspen Ave, Fruita, CO 81521

    Charming 1,800 SF building in downtown Fruita for lease.

    • Prime downtown Fruita location, neighboring shops and restaurants.
    • Flexible Downtown Mixed‑Use zoning allows for diverse business opportunities.
    • Historic 1,800 SF building.
    • Includes three private parking spaces.
    • Built in 1926.
    Updated: Feb 23
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    Grand Junction Office/Shop Space
    $3,150 / Mo
    3,800 SF

    Grand Junction Office/Shop Space

    3,800+ SF flex space with showroom and shop spaces.

    2872 I-70 Business Loop, Grand Junction, CO 81501
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    Grand Junction Office/Shop Space
    $8,750 / Mo
    12,000 SF

    Grand Junction Office/Shop Space

    12,000 SF office/shop space with flexible industrial zoning.

    2872 I-70 Business Loop, Grand Junction, CO 81501
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    Grand Junction Warehouse with Office
    $6,600 / Mo
    13,200 SF

    Grand Junction Warehouse with Office

    Warehouse with 1,200 SF office and yard space.

    2868 I-70 Business Loop, Grand Junction, CO 81504
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    Grand Junction High-End Office Space
    $7,334 / Mo
    21,805 SF

    Grand Junction High-End Office Space

    Prime office space in Grand Junction near hospitals.

    2474 2Nd St, Grand Junction, CO 81505
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    Grand Junction Commercial Retail Space
    $2,133 / Mo
    1,600 SF

    Grand Junction Commercial Retail Space

    Turnkey 1,600 SF commercial space ideal for office use.

    2478 Patterson Rd, Grand Junction, CO 81505
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    Renovated Retail Space on North Avenue
    $1,994 / Mo
    6,500 SF

    Renovated Retail Space on North Avenue

    End-cap retail space with high visibility and recent renovations.

    1059 North Ave, Grand Junction, CO 81501
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    Riverside Parkway Office/Warehouse Space
    $2,500 / Mo
    2,500 SF

    Riverside Parkway Office/Warehouse Space

    Functional office and accessible warehouse space in Grand Junction, CO.

    2479 Riverside Pkwy, Grand Junction, CO 81505
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    Retail Space in Grand Junction
    $2,250 / Mo
    1,215 SF

    Retail Space in Grand Junction

    Centrally located retail space with parking and storage.

    1750 North Ave, Grand Junction, CO 81501
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    Versatile Grand Junction Commercial Space
    $6,018 / Mo
    8,024 SF

    Versatile Grand Junction Commercial Space

    8,024 SF freestanding building on North Avenue.

    2825 North Ave, Grand Junction, CO 81501
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    Grand Junction Commercial Flex Space
    $1,200 / Mo
    961 SF

    Grand Junction Commercial Flex Space

    Flex space with office, storage, and warehouse components available.

    2477 Commerce Blvd, Grand Junction, CO 81505
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    Grand Junction Flex Space Available
    $2,200 / Mo
    2,300 SF

    Grand Junction Flex Space Available

    2,300 SF flex space ideal for small service business.

    21 1/2 Rd, Grand Junction, CO 81505
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    Grand Junction Commercial Flex Space
    $4,500 / Mo
    3,590 SF

    Grand Junction Commercial Flex Space

    Versatile workspace in a strategic, high-visibility location near major retailers.

    464 Base Rock St, Grand Junction, CO 81501
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    Retail/Office/Medical Space Available
    $7,305 / Mo
    18,353 SF

    Retail/Office/Medical Space Available

    4,870 SF space suitable for retail, office, or medical.

    561 25 Rd, Grand Junction, CO 81505
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    Grand Junction Office Suite For Lease
    $1,400 / Mo
    11,788 SF

    Grand Junction Office Suite For Lease

    1,380 SF office suite available for lease.

    3198 F Rd, Grand Junction, CO 81504
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    Grand Junction Warehouse/Office Space
    $1,200 / Mo
    5,976 SF

    Grand Junction Warehouse/Office Space

    1,178 sq ft warehouse/office in prime location for rent.

    1700 I-70 Business Loop, Grand Junction, CO 81501
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    Grand Junction Commercial Office/Retail Space
    $595 / Mo
    6,336 SF

    Grand Junction Commercial Office/Retail Space

    Commercial office and retail units available in Grand Junction, Colorado.

    1460 North Ave, Grand Junction, CO 81507
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    Downtown Grand Junction Retail Space
    $4,500 / Mo
    3,113 SF

    Downtown Grand Junction Retail Space

    Reconstructed retail space with high-end finishes in downtown Grand Junction.

    344 Main St, Grand Junction, CO 81501
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    Grand Junction Office Space Available
    $3,750 / Mo
    45,264 SF

    Grand Junction Office Space Available

    2,250 SF office space near St. Mary's Hospital.

    120 W Park Dr, Grand Junction, CO 81505
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    Grand Junction Office/Warehouse Space
    $1,800 / Mo
    1,493 SF

    Grand Junction Office/Warehouse Space

    Office and warehouse space available March 1, 2026.

    784 Valley Ct, Grand Junction, CO 81505
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    Grand Junction Office/Warehouse Unit
    $4,200 / Mo
    42,840 SF

    Grand Junction Office/Warehouse Unit

    Office/warehouse unit with fenced yard in Grand Junction, Colorado.

    685 W Gunnison Ave, Grand Junction, CO 81501
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    Victorian Building Office Suites
    $980 / Mo
    3,291 SF

    Victorian Building Office Suites

    Downtown office suites in a converted Victorian building for rent.

    838 Grand Ave, Grand Junction, CO 81501
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    Grand Junction Commercial Property For Rent
    $1,218 / Mo
    7,301 SF

    Grand Junction Commercial Property For Rent

    Prime commercial property with high visibility and traffic.

    216 North Ave, Grand Junction, CO 81501
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    Mesa County, CO Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in Mesa County, CO with 475 listings featured on our commercial real estate exchange. The current inventory includes 121,266,161,280 square feet of properties with an estimated lease value of $1,860 /Mo.

    Estimated lease rates for Commercial real estate in Mesa County, CO begin at $0.55 SF/Yr, with an average of $10 SF/Yr and extend to $270 SF/Yr.
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