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Research Triangle Park, NC Retail Properties & Spaces for Lease

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Found 39 retail property listings for lease in Research Triangle Park, NC, averaging $25/SF/YR. Use lease type data to compare options faster.
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Standalone Flex Building
Updated: May 17
Standalone Flex Building

3821 Durham Chapel Hill Blvd, Durham, NC 27707

$23.11 SF/Yr
18,176 sqft
Approximately ±18,176 SF standalone building on approximately 2 acres
±10’ clear height in front and side areas with four 8’ drive‑in doors
±17’ clear height in rear warehouse with two 10’ drive‑in doors
High‑visibility frontage along Durham‑Chapel Hill Blvd (US‑15/501)
Traffic counts of ±20,000 VPD on Durham‑Chapel Hill Blvd
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Erwin Road Mixed-Use Retail Space
Updated: Sep 25, 2025
Erwin Road Mixed-Use Retail Space

2812 & 2816 Erwin Rd, Durham, NC 27705

$25 SF/Yr
1,696 sqft
Walking distance to Duke University Hospital, Duke University, Durham VA Hospital, and Lenox Baker Children’s Hospital
Class A mixed‑use development with luxury apartments, offices, and retail
Ample surface and structured parking
Convenient to US 15‑501 and NC 147/Durham Freeway
Property adjoins a 141‑key AC Hotel by Marriott
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Open-Plan Retail Suite
Open-Plan Retail Suite

4810 Hope Valley Road, Suite 107, Durham, NC 27707

Contact for pricing
Multi-tenant  2,652 sqft
18,480 VPD  Randy's Pizza, Wine & Design co-tenants  Highway access

Retail space with a private office, two restrooms, and ample parking in a mixed-use center.

Open floor plan  Private office  Two restrooms
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Flex Space with Showroom
Flex Space with Showroom

3220 Guess Road, Durham, NC 27705

Duke Homestead
Contact for pricing
6,864 sqft  3-phase  Built 1989
Highway access  Road access  Commercial Neighborhood

Glass retail frontage, warehouse storage, and a roll-up door create a versatile commercial configuration.

Multiple restrooms  Warehouse storage  Roll-up door  3 phase power
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Downtown Retail Space with Terrace
Downtown Retail Space with Terrace

500 East Main Street, Durham, NC 27701

Downtown
$26 SF/Yr

Ground-floor retail in a 248-unit luxury apartment building with an outdoor dining terrace and structured customer parking.

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Power Center with Office Space
Power Center with Office Space

4120 University Dr, Durham, NC 27707

Contact for pricing
Multi-tenant  30,600 sqft
Super Target, Sam's Club co-tenants  Highway access

Office Depot building scheduled for lease availability in April 2027 within an established Durham retail center.

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Downtown Durham Retail Space Available
Downtown Durham Retail Space Available

400 West Main Street, Durham, NC 27701

Downtown
Contact for pricing
12,473 sqft

Prime retail spaces in a vibrant downtown location.

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Riverview Shopping Center
Riverview Shopping Center

5116 North Roxboro Street, Durham, NC 27712

Old Farm
Contact for pricing
15,500 sqft

Retail property at the intersection of Seven Oaks Road and North Roxboro Street in north Durham.

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Retail Salon-Style Suite
Retail Salon-Style Suite

413 East Chapel Hill st, Durham, NC 27701

Rigsbee Hill
Contact for pricing
1,474 sqft  Built 1950

Retail bay with salon build-out, high ceilings, and exposed brick walls on a modified gross lease structure.

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Retail Space in Luxury Development
Retail Space in Luxury Development

441 South Dillard Street, Durham, NC 27701

Downtown
Contact for pricing
6,000 sqft

Retail space available in a luxury residential development.

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Mixed-Use Development Retail Space
Mixed-Use Development Retail Space

200 Morris Street, Durham, NC 27701

Central Park
Contact for pricing
3,983 sqft

Retail space available in a large mixed-use development.

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Retail Space in North Durham
Retail Space in North Durham

3500 North Roxboro Street, Durham, NC 27704

Bragtown
Contact for pricing
22,425 sqft

Retail and restaurant spaces available in a busy shopping center.

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Retail Space with Interstate Access
Retail Space with Interstate Access

4901 Page Rd, Durham, NC 27703

Contact for pricing
Highway access

Retail space in RTP with direct access from the Page Road interstate ramp and visibility from I-540 and I-40.

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Durham Retail Center Space Available
Durham Retail Center Space Available

3457 Hillsborough Road, Durham, NC 27705

Contact for pricing
11,868 sqft

Retail space for lease in Durham Festival Center.

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Street-Facing Retail Space
Street-Facing Retail Space

211 Rigsbee Ave, Durham, NC 27701

Central Park
Contact for pricing
5,280 sqft  Ground Floor

An open, two-level configuration combines ground-floor access with usable lower-level space.

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Retail Space Near Southpoint
Retail Space Near Southpoint

6901 Fayetteville Road, Durham, NC 27713

Contact for pricing
13,950 sqft

Retail space available near The Streets at Southpoint.

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Vibrant Retail Space in Durham
Vibrant Retail Space in Durham

905 West Main Street, Durham, NC 27701

Golden Belt
Contact for pricing
24,174 sqft

Retail space in a lively, historic Durham community.

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GeerHouse Ground-Floor Retail
GeerHouse Ground-Floor Retail

620 Foster Street, Durham, NC 27701

Central Park
Contact for pricing
Multi-tenant  Ground  Built 2023

Ground-floor retail space with an outdoor dining terrace, structured parking, and signage opportunities.

Outdoor dining terrace  Structured parking  Signage and branding opportunities
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Restored Loft-Style Retail Suites
Restored Loft-Style Retail Suites

200 North Mangum Street, Durham, NC 27701

Central Park
Contact for pricing
Multi-tenant
Corner location

Two plug-and-play suites support retail or office use.

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One City Center Mixed-Use High-Rise
One City Center Mixed-Use High-Rise

110 Corcoran St., Durham, NC 27701

Central Park
Contact for pricing
27-story

Mixed-use space is arranged within a prominent high-rise building.

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Loft-Style Retail Space
Loft-Style Retail Space

501 Washington St., Durham, NC 27701

Warehouse District
Contact for pricing
Built 1924 / renov 2020

A 2020 upfit combines historic character with exposed architectural finishes.

Loft aesthetics  Soaring volume  Exposed roof trusses  Exposed brick walls
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Masonry Storefront Building
Masonry Storefront Building

125 Orange St, Durham, NC 27701

Central Park
Contact for pricing
Built 1900  masonry

Planned renovation will update a historic commercial space for food, beverage, and neighborhood retail concepts.

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Ground-Floor Retail Space
Ground-Floor Retail Space

311 Liggett Street, Durham, NC 27701

Triple net (NNN) Warehouse District
Contact for pricing
Built 2023

Street-level commercial space integrated into a 2023 multifamily development with a dining terrace, signage opportunities, and customer parking.

Outdoor dining terrace  Signage opportunities
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Downtown Durham Retail Space
Downtown Durham Retail Space

321 W Corporation St, Durham, NC 27701

Central Park
Contact for pricing
Built 2020

Retail space in Downtown Durham's Central Park District.

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Research Triangle Park, NC Retail properties & Spaces Lease Rates & Market Statistics

Browse 39 Retail properties & Spaces for lease in Research Triangle Park, NC on Realmo, a commercial real estate marketplace serving the Research Triangle Park area. The current inventory totals 323,235 square feet of properties — an average of ~8,300 SF per listing.

Asking lease rates for Retail properties & Spaces in Research Triangle Park start at $23.11 SF/Yr, average $25.40 SF/Yr, and reach $27.50 SF/Yr at the top of the market. Pricing across the market is relatively uniform, which simplifies like-for-like comparison between listings. The local average of $25.40 SF/Yr is 26% above the North Carolina state average of $20.21 SF/Yr.

Research Triangle Park accounts for 100% of the 39 retail properties & spaces currently available across Durham County, where a nearby market includes Durham. By space type, the market includes 15 shopping centers and 9 storefront properties.

How to lease retail space in Research Triangle Park, NC

  1. Profile your customer and concept. Define who you serve and how much space your store format needs (front-of-house plus storage and back-of-house).
  2. Analyze foot traffic and competition. Use Location Intelligence to compare neighborhoods in Research Triangle Park, NC by foot traffic, demographics, and retail saturation before touring specific spaces.
  3. Check zoning, permitted use, and signage. Confirm that your business type is allowed at the address and review signage rights since visibility drives retail discoverability.
  4. Understand the lease structure. Retail deals often use NNN or percentage leases (base rent plus 5–10% of sales), with CAM charges added on top.
  5. Calculate total occupancy cost. Run base rent, CAM, taxes, and insurance through the Lease Calculator. Aim to keep it in the low double digits relative to projected sales.
  6. Negotiate protections and sign. Push for a TI allowance, free-rent period, and an exclusive use clause blocking direct competitors, then have an attorney review before signing.
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