Research Triangle Park, NC Commercial Real Estate for Sale

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Two-Story Office and Medical Building
Updated: Aug 7, 2025
Two-Story Office and Medical Building

4400 Ben Franklin Boulevard, Durham, NC 27704

$3,499,000
21,532 sqft 2.10 AC lot
Significant income generation from leased area: $227,739 in 2024.
Large, multi‑functional commercial building with 21,532 total square feet.
Located in a sought‑after office/medical park in northern Durham County.
Flexible space suitable for various professional uses (medical, office, education, law).
Features include an elevator, ample storage, and a loading dock.
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4400 Ben Franklin Boulevard, Durham, NC 27704

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Retail Building with Walk-In and Roll-Up Basement
Updated: Jun 10
Retail Building with Walk-In and Roll-Up Basement

501 N Mangum Street, Durham, NC 27701

$5,000,000
8,000 sqft 0.69 AC lot
8,000 SF retail building plus 4,000 SF basement
Basement accessible via walk‑in and roll‑up doors
0.69‑acre fenced lot with parking
Public water and public sewer
Metal siding construction; built in 1954
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Established Durham Mechanical Shop For Sale
Established Durham Mechanical Shop For Sale

2410 Angier Avenue, Durham, NC 27703

$1,000,000
4,000 sqft 0.81 AC lot

Income-producing mechanical shop with five service bays and ample parking.

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Durham Commercial Land Opportunity
Durham Commercial Land Opportunity

3421 N Duke Street, Durham, NC 27704

$1,300,000
2,386 sqft 0.61 AC lot

Two adjacent properties for sale in Durham's growing corridor.

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Industrial Flex Property with Fenced Yard
Industrial Flex Property with Fenced Yard

1015 Ellis Road, Durham, NC 27703

$1,385,000
4,940 sqft 0.74 AC lot

Three-building industrial flex site includes multiple garage bays, a converted office, and a fully fenced yard for outdoor operations.

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Live-Work Craftsman Bungalow with Porch
Live-Work Craftsman Bungalow with Porch

1814 Chapel Hill Road, Durham, NC 27707

$493,000
1,922 sqft 0.30 AC lot

1938 Craftsman live-work bungalow with central air, natural gas forced-air heat, and an unfinished walk-out basement.

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Leased First-Floor Office Condominium
Leased First-Floor Office Condominium

5003 Southpark Drive, Durham, NC 27713

$389,000
1,386 sqft

First-floor office condominium in Southpark Professional Center, currently leased through July 2029 with tenant option to renew.

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Automotive Retail Facility
Automotive Retail Facility

5412 S Miami Blvd, Durham, NC 27703

$2,650,745
6,534 sqft 1.75 AC lot

Leased 6,534 SF automotive-oriented facility on 1.75 acres with corridor visibility along S Miami Boulevard.

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Durham Commercial Investment Opportunity
Durham Commercial Investment Opportunity

901 E Trinity Avenue, Durham, NC 27704

$730,000
2,640 sqft 0.23 AC lot

Tenant-occupied commercial property in Durham with high visibility.

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Gently Rolling Development Land
Gently Rolling Development Land

6900 / 6918 Russell Road, Durham, NC 27712

$2,995,000
90.66 AC lot

90+ acres with open fields, timber, and rolling topography for development or private estate uses near major routes.

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Historic Corner Retail Storefront
Historic Corner Retail Storefront

301 E. Chapel Hill St., Durham, NC 27701

$1,895,000
5,366 sqft

Early 1900s storefront with corner exposure and a walk-out basement for potential additional usable space.

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Cleared Development Land Parcel
Cleared Development Land Parcel

2217 S Miami Blvd., Durham, NC 27703

$550,000
3.75 AC lot

Cleared commercial land parcel near RTP and RDU Airport, zoned primarily R-20 with a small CN portion.

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Commercial Land Assemblage
Commercial Land Assemblage

507 S Alston Avenue, Durham, NC 27703

$1,500,000
1.29 AC lot

Multiple adjacent commercial parcels offered for future development, subject to city and county approvals.

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Retail Building with Fenced Parking
Retail Building with Fenced Parking

501 N Mangum, Durham, NC 27701

$5,000,000
8,000 sqft

Small retail building with fenced parking and basement space accessible by walk-in and roll-up doors.

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Durham Land Investment Opportunity
Durham Land Investment Opportunity

503 Santee Road, Durham, NC 27704

$2,000,000
22.43 AC lot

22.43 acres of land with investment potential in Durham.

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Durham Land Near I-85
Durham Land Near I-85

Avondale Drive, Durham, NC 27704

$149,000
9.64 AC lot

9.64 acres of commercial land off I-85 in Durham.

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Office Building for Sale
Office Building for Sale

4007 N Roxboro Street, Durham, NC 27704

$2,500,000
2,605 sqft

Office building for sale at 4007 N Roxboro Street, positioned across from Lowes Home Improvements.

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Commercial Land Zoned Commercial General
Commercial Land Zoned Commercial General

2214 T W Alexander Drive, Durham, NC 27703

$2,755,000
5.79 AC lot

A flexible commercial land parcel offering development versatility under Commercial General zoning for a range of uses.

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Automotive Service Shop with Bays
Automotive Service Shop with Bays

2410 Angier, Durham, NC 27703

$1,000,000
4,000 sqft

Tenant-occupied mechanical shop with five service bays, office, dedicated bathrooms, and ample parking.

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Commercial General Development Land
Commercial General Development Land

2214 T W Alexander Drive, Durham, NC 27703

$2,755,000
5.79 AC lot

5.79-acre commercial land zoned Commercial General along T W Alexander Drive.

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Versatile Retail and Office Space
Versatile Retail and Office Space

2620 Angier, Durham, NC 27703

$125,000
887 sqft

Versatile storefront and office space with on-site parking and convenient access to major routes near Downtown Durham.

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Rural Residential Land Tract
Rural Residential Land Tract

Southview Road, Durham, NC 27703

$1,950,000
62.42 AC lot

Zoned RR rural residential farmland totaling 62.42 acres, currently in the forestry program.

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Live-Work Craftsman Bungalow
Live-Work Craftsman Bungalow

1814 Chapel Hill, Durham, NC 27707

$498,000
1,922 sqft

Craftsman-style home with office-ready interiors, a fireplace front parlor, and flexible outdoor parking behind a detached garage.

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Rural Residential Land Tract
Rural Residential Land Tract

391 & 409 Southview Road, Durham, NC 27703

$750,000
23.48 AC lot

23.48-acre RR-zoned tract in a forestry program with nearby winery/brewery and an adjacent 18-hole golf course.

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Research Triangle Park, NC Commercial Real Estate Market Trends and Statistics

Explore 143 commercial real estate for sale in Research Triangle Park, NC, showcased through 143 active listings on our real estate platform. These investment opportunities span a total of 1,963,488 square feet of properties for sale, with an estimated market value of $107,287,444.

Sale prices for business properties in Research Triangle Park, NC start at $59,000, averaging $1,532,677, and reaching up to $8,000,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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Population 5

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New vs delisted commercial listings in Durham County

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