Key Largo, FL Office Units for Rent & Lease

Updated: Nov 27, 2025

Key Largo Commercial Opportunity

106600 Overseas Highway, Key Largo, FL 33037

$3,000/Mo

2,400 sqft

Highway frontage building
2,400' of upstairs space for lease
Downstairs is leased to FDOT contractor
Adjacent property has storage space available for additional rental starting at $295 per space per month
Adjacent property has 400' of water dockage for boats, sailboats, etc.

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Updated: Apr 28

Office Space for Lease

103301 Overseas Hwy, Key Largo, FL 33037

$1,250/Mo

Office for rent
YearBuilt: 1984

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Class A Multi-Story Office Center

94500 Overseas Highway, Key Largo, FL 33037

$10,900/Mo

Multi-story office suite with a ground-level reception and private offices, plus an upper level with open space and a sun deck.

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Retail and Office Space Available

103400 Overseas Hwy, Key Largo, FL

Contact for pricing

4,000 sqft

Retail and office spaces for lease in Key Largo.

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Based on your search, we've compiled 13 Potential Opportunities for your consideration. Besides 4 Active listings in Key Largo, FL, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 5 Properties for Sales.

Office Units for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Medical Office Suite in Professional Center

312-925 Ne 30th Ter, Homestead, FL 33033

$6,000/Mo

2,122 sqft

Office suite ready for new build out with tenant-controlled HVAC and high-speed internet in a Class B professional center.

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Second-Floor Office Suite with Restrooms

33004 S Dixie Hwy, Florida City, FL 33034

$29/Mo

Entire second-floor office suite with polished cement floors, high ceilings, and private restrooms on US 1 frontage.

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Flex Warehouse with Street-Level Loading

12 NE 3rd Street, Florida City, FL 33034

$18/Mo

Vacant flex space with office areas under AC, two street-level loading doors, and strong Turnpike signage exposure.

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Small Office Suite with Conference Room

202-123 N Krome Ave, Homestead, FL 33030

$650/Mo

Small office suite includes space for two desks, a four-person conference room, and a coffee room.

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Similar Spaces for Sale in Key Largo, FL

Consider Similar Space for Sale. We found 5 Spaces matching your search parameters.

Prime US-1 Mixed-Use Opportunity

92295 Old State Road, Key Largo, FL 33070

$2,895,000

6,241 sqft 0.86 AC lot

Mixed-use commercial building with highway frontage in Tavernier.

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High-Frontage Mixed-Use Building with Suites

92295 Old State Road, #4A, Key Largo, FL 33070

$2,895,000

6,214 sqft 0.86 AC lot

Concrete mixed-use building with six exterior-access suites and extensive US-1 frontage for flexible retail, office, and medical use.

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Two-Story Office Building with Covered Parking

106240 Overseas Hwy, Key Largo, FL 33037

$1,925,000

3,936 sqft 0.50 AC lot

Two-story office building with newly installed metal roof, leased ground floor space, and additional second-story area available.

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Free-Standing Mixed-Use Retail Building

100636 Overseas Highway, Key Largo, FL 33037

$1,790,000

Ground-floor storefront with office and storage, plus an upstairs 3BD/3BA renovated apartment and parking on US-1.

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Office Space Available