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    Saint Helena Island, SC Office Properties & Spaces for Sale

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    Versatile Commercial Property on Highway 21
    $595,000
    3,520 SF

    Versatile Commercial Property on Highway 21

    2123 Sea Island Pkwy, Saint Helena Island, SC 29920

    Mixed-use property with high visibility and flexible layout.

    • Prime Hwy‑21 frontage on Harbor Island with high visibility.
    • Versatile 3,520 SF three‑story building suitable for office, live‑work, residential, or short‑term rental use.
    • Gorgeous Lowcountry water and marsh views.
    • Proximity to Fripp Island, Harbor Island, and Dataw Island.
    • Includes a 1,000 SF utility shed and paved parking lot.
    Updated: Feb 16
    View details
    Based on your search, we've compiled 18 Potential Opportunities for your consideration. Besides 1 Active listings in Saint Helena Island, SC, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 12 Off-Market properties to explore as potential leads, plus 1 Land Listings that present a potential for development.

    Explore Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Lady's Island Office Space
    Contact for pricing
    8,944 SF

    Lady's Island Office Space

    Conveniently located 1,250 SF office space on major thoroughfare.

    189 Sea Island Pkwy, Beaufort, SC 29907
    View details
    Waterfront Mixed-Use Landmark Property
    $6,500,000
    5,000 SF

    Waterfront Mixed-Use Landmark Property

    Unique mixed-use property with panoramic waterfront views in downtown Beaufort.

    916 Bay St, Beaufort, SC 29902
    View details
    Office Warehouse Units For Sale
    Contact for pricing
    10,000 SF

    Office Warehouse Units For Sale

    Two warehouse units with office space, available October 1, 2025.

    12 Cardinal Rd, Hilton Head Island, SC 29926
    View details
    Hilton Head Commercial Space Available
    Contact for pricing
    3,500 SF

    Hilton Head Commercial Space Available

    Mixed-use commercial space ideal for retail, office, or storage.

    11 Mathews Dr, Hilton Head Island, SC 29026
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Highway Frontage Land Parcel
    $429,000
    3.90 Acres

    Highway Frontage Land Parcel

    Land with flexible zoning and high visibility on Sea Island.

    785 Sea Island Pkwy, Saint Helena Island, SC 29920
    View details

    Explore Off-Market Properties in Saint Helena Island, SC

    Consider similar Off-Market properties in Saint Helena Island, SC. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    1000 Sea Is Pkwy

    1000 Sea Is Pkwy

    OFFICE BUILDING • 2,100 SF
    Value Estimation by Request
    1000 Sea Is Pkwy, Saint Helena Island, SC 29920-4313
    View details
    572 Sea Is Pkwy

    572 Sea Is Pkwy

    OFFICE BUILDING • 1,232 SF
    Value Estimation by Request
    572 Sea Is Pkwy, Saint Helena Island, SC 29920-4205
    View details
    211 Cotton Dike Rd

    211 Cotton Dike Rd

    OFFICE BUILDING • 2,800 SF
    Value Estimation by Request
    211 Cotton Dike Rd, Saint Helena Island, SC 29920-3804
    View details
    25 Langford Rd

    25 Langford Rd

    OFFICE BUILDING • 864 SF
    Value Estimation by Request
    25 Langford Rd, Saint Helena Island, SC 29920
    View details
    2 Hbr Dr

    2 Hbr Dr

    OFFICE BUILDING • 1,400 SF
    Value Estimation by Request
    2 Hbr Dr, Saint Helena Island, SC 29920-7164
    View details
    34 Susie Ln

    34 Susie Ln

    OFFICE BUILDING • 1,072 SF
    Value Estimation by Request
    34 Susie Ln, Saint Helena Island, SC 29920
    View details
    2119 Sea Is Pkwy

    2119 Sea Is Pkwy

    OFFICE BUILDING • 1,440 SF
    Value Estimation by Request
    2119 Sea Is Pkwy, Saint Helena Island, SC 29920-5001
    View details
    2143 Sea Is Pkwy

    2143 Sea Is Pkwy

    OFFICE BUILDING • 1,112 SF
    Value Estimation by Request
    2143 Sea Is Pkwy, Saint Helena Island, SC 29920-5001
    View details
    1551 Sea Is Pkwy

    1551 Sea Is Pkwy

    OFFICE BUILDING • 5,348 SF
    Value Estimation
    $725,000
    1551 Sea Is Pkwy, Saint Helena Island, SC 29920-4001
    View details
    159 Ephraim Rd

    159 Ephraim Rd

    OFFICE BUILDING • 2,624 SF
    Value Estimation
    $795,000
    159 Ephraim Rd, Saint Helena Island, SC 29920-6111
    View details
    Frances Butler Ln

    Frances Butler Ln

    MEDICAL BUILDING • 9,412 SF
    Value Estimation by Request
    Frances Butler Ln, Saint Helena Island, SC 29920
    View details
    Saint Helena Island, SC 29920

    Saint Helena Island, SC 29920

    OFFICE BUILDING • 1,411 SF
    Value Estimation by Request
    Saint Helena Island, SC 29920
    View details

    Saint Helena Island, SC Office Properties & Spaces Investment Opportunities Market Analysis

    Explore 13 office properties & spaces for sale in Saint Helena Island, SC on our real estate platform. These investment opportunities span a total of 833,738 square feet of properties for sale, with an estimated market value of $28,185,000.

    Sale prices for office spaces in Saint Helena Island, SC start at $60,000, averaging $4,697,500, and reaching up to $26,255,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Browse Office Properties & Spaces for Sale Near Saint Helena Island, SC

    Popular Searches in Saint Helena Island, SC

    Most Searched ZIP Codes in Saint Helena Island, SC

    • 29920

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