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    Lafayette County, FL Office Properties & Spaces for Sale

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    Cape Coral, FL Port Charlotte, FL Miami, FL
    Commercial Property in Growing Region
    $860,000
    1.46 Acres

    Commercial Property in Growing Region

    130 NE Clyde Avenue, Mayo, FL 32066

    1.46-acre property suitable for various commercial ventures in Mayo, FL.

    • Strategic location halfway between Gainesville and Tallahassee in Mayo, the county seat of Lafayette County.
    • Large 1.46‑acre lot with a 2,623 square foot building suitable for various commercial ventures.
    • Located in the 'Gateway to Growth' region of North Central Florida with a supportive environment for economic development.
    • Built in 2019, featuring brick construction, central heating and air, and a blacktop driveway.
    • Zoning and location suitable for a wide range of service‑oriented businesses, including retail, office, catering, or skilled trades.
    Updated: Sep 8, 2025
    View details
    Based on your search, we've compiled 36 Potential Opportunities for your consideration. Besides 1 Active listings in Lafayette County, FL, we suggest exploring several alternatives: similar 31 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    16.48 Acre Commercial Tract
    $3,000,000
    16.68 Acres

    16.48 Acre Commercial Tract

    16.48 acre commercial tract with high visibility and traffic.

    0 W W US HWY 90, Lake City, FL 32024
    View details
    Commercial Lot in Developing Area
    $100,000
    1.00 Acre

    Commercial Lot in Developing Area

    Commercial lot in a rapidly developing area near major routes.

    TBD SW COMMERCE DR, Lake City, FL 32025
    View details
    Commercial Lot Near I-75
    $300,000
    2.04 Acres

    Commercial Lot Near I-75

    Commercial land in a rapidly developing area near major routes.

    TBD SW COMMERCE DR, Lake City, FL 32025
    View details
    Commercial Lot Near I-75
    $500,000
    3.06 Acres

    Commercial Lot Near I-75

    Commercial land in a rapidly developing area near major routes.

    TBD SW COMMERCE DR, Lake City, FL 32025
    View details

    Explore Off-Market Properties in Lafayette County, FL

    Consider similar Off-Market properties in Lafayette County, FL. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    757 State Rd 51

    757 State Rd 51

    OFFICE BUILDING • 646 SF
    Value Estimation
    $2,200,000
    757 State Rd 51, Mayo, FL 32066-6609
    View details
    4485 County Rd 53

    4485 County Rd 53

    OFFICE BUILDING • 4,296 SF
    Value Estimation by Request
    4485 County Rd 53, Mayo, FL 32066-2834
    View details
    157 Main St

    157 Main St

    OFFICE BUILDING • 4,631 SF
    Value Estimation by Request
    157 Main St, Mayo, FL 32066-4808
    View details
    110 Fletcher Ave

    110 Fletcher Ave

    OFFICE BUILDING • 1,597 SF
    Value Estimation by Request
    110 Fletcher Ave, Mayo, FL 32066-4550
    View details
    126 Land Ave

    126 Land Ave

    OFFICE BUILDING • 1,452 SF
    Value Estimation by Request
    126 Land Ave, Mayo, FL 32066-4824
    View details
    311 Crawford St

    311 Crawford St

    OFFICE BUILDING • 4,266 SF
    Value Estimation by Request
    311 Crawford St, Mayo, FL 32066-4611
    View details
    306 County Rd 300

    306 County Rd 300

    OFFICE BUILDING • 1,200 SF
    Value Estimation by Request
    306 County Rd 300, Mayo, FL 32066
    View details
    258 Main St

    258 Main St

    PROFESSIONAL BUILDING • 1,998 SF
    Value Estimation by Request
    258 Main St, Mayo, FL 32066
    View details
    4573 County Rd 53

    4573 County Rd 53

    OFFICE BUILDING • 1,777 SF
    Value Estimation by Request
    4573 County Rd 53, Mayo, FL 32066-2818
    View details
    135 Bloxham St

    135 Bloxham St

    OFFICE BUILDING • 814 SF
    Value Estimation by Request
    135 Bloxham St, Mayo, FL 32066
    View details
    Cr 53

    Cr 53

    OFFICE BUILDING • 6,688 SF
    Value Estimation by Request
    Cr 53, Mayo, FL 32066
    View details
    207 Main St

    207 Main St

    OFFICE BUILDING • 1,494 SF
    Value Estimation by Request
    207 Main St, Mayo, FL 32066
    View details
    226 Main St

    226 Main St

    OFFICE BUILDING • 1,074 SF
    Value Estimation by Request
    226 Main St, Mayo, FL 32066
    View details
    710 Main St

    710 Main St

    PROFESSIONAL BUILDING • 8,783 SF
    Value Estimation by Request
    710 Main St, Mayo, FL 32066-4127
    View details
    348 Fletcher Ave

    348 Fletcher Ave

    OFFICE BUILDING • 3,082 SF
    Value Estimation by Request
    348 Fletcher Ave, Mayo, FL 32066-4502
    View details
    224 Park St

    224 Park St

    Individual retail properties • 1,080 SF
    Value Estimation by Request
    224 Park St, Mayo, FL 32066
    View details
    115 Park St

    115 Park St

    OFFICE BUILDING • 1,000 SF
    Value Estimation by Request
    115 Park St, Mayo, FL 32066
    View details
    118 Monroe Ave

    118 Monroe Ave

    OFFICE BUILDING • 614 SF
    Value Estimation by Request
    118 Monroe Ave, Mayo, FL 32066
    View details
    116 Monroe Ave

    116 Monroe Ave

    OFFICE BUILDING • 770 SF
    Value Estimation by Request
    116 Monroe Ave, Mayo, FL 32066-4710
    View details
    262 Main St

    262 Main St

    OFFICE BUILDING • 2,500 SF
    Value Estimation by Request
    262 Main St, Mayo, FL 32066
    View details
    874 Main St

    874 Main St

    PROFESSIONAL BUILDING • 2,328 SF
    Value Estimation by Request
    874 Main St, Mayo, FL 32066-5600
    View details
    974 Main St

    974 Main St

    PROFESSIONAL BUILDING • 2,560 SF
    Value Estimation by Request
    974 Main St, Mayo, FL 32066-5631
    View details
    120 Main St

    120 Main St

    OFFICE BUILDING • 14,804 SF
    Value Estimation by Request
    120 Main St, Mayo, FL 32066-4095
    View details

    Lafayette County, FL Office Properties & Spaces Investment Opportunities Market Analysis

    Explore 32 office properties & spaces for sale in Lafayette County, FL on our real estate platform. These investment opportunities span a total of 3,451,009 square feet of properties for sale, with an estimated market value of $6,135,000.

    Sale prices for office spaces in Lafayette County, FL start at $90,000, averaging $766,875, and reaching up to $2,200,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Browse Office properties & Spaces for Sale Near Lafayette, FL

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