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    Mayo, FL Office Properties & Spaces for Sale

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    Lehigh Acres, FL Cape Coral, FL Port Charlotte, FL
    Commercial Property in Growing Region
    $860,000
    1.46 Acres

    Commercial Property in Growing Region

    130 NE Clyde Avenue, Mayo, FL 32066

    1.46-acre property suitable for various commercial ventures in Mayo, FL.

    • Strategic location halfway between Gainesville and Tallahassee in Mayo, the county seat of Lafayette County.
    • Large 1.46‑acre lot with a 2,623 square foot building suitable for various commercial ventures.
    • Located in the 'Gateway to Growth' region of North Central Florida with a supportive environment for economic development.
    • Built in 2019, featuring brick construction, central heating and air, and a blacktop driveway.
    • Zoning and location suitable for a wide range of service‑oriented businesses, including retail, office, catering, or skilled trades.
    Updated: Sep 8, 2025
    View details
    Based on your search, we've compiled 39 Potential Opportunities for your consideration. Besides 1 Active listings in Mayo, FL, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 30 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

    Explore Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Commercial Building in Perry, FL
    $215,000
    1,642 SF

    Commercial Building in Perry, FL

    Commercial building with medical office potential in Perry, Florida.

    1204 Center Street North, Perry, FL 32347
    View details
    8445 FT on 0.89 AC Lot For Sale
    $230,000
    8,445 SF

    8445 FT on 0.89 AC Lot For Sale

    8445 FT on 0.89 AC Lot For Sale

    118 Park Street, Perry, FL 32347
    View details
    Florida Warehouse with Storage Lot
    $400,000
    2,700 SF

    Florida Warehouse with Storage Lot

    Centrally located warehouse with storage lot in Florida.

    619 Goldkist Boulevard, Live Oak, FL 32064
    View details
    Mainstreet Urgent Care For Sale
    $2,290,000
    3,200 SF

    Mainstreet Urgent Care For Sale

    NNN leased urgent care in Live Oak, Florida.

    1702 Ohio Ave N, Live Oak, FL 32064
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    16.48 Acre Commercial Tract
    $3,000,000
    16.68 Acres

    16.48 Acre Commercial Tract

    16.48 acre commercial tract with high visibility and traffic.

    0 W W US HWY 90, Lake City, FL 32024
    View details
    Commercial Lot in Developing Area
    $100,000
    1.00 Acre

    Commercial Lot in Developing Area

    Commercial lot in a rapidly developing area near major routes.

    TBD SW COMMERCE DR, Lake City, FL 32025
    View details
    Commercial Lot Near I-75
    $300,000
    2.04 Acres

    Commercial Lot Near I-75

    Commercial land in a rapidly developing area near major routes.

    TBD SW COMMERCE DR, Lake City, FL 32025
    View details
    Commercial Lot Near I-75
    $500,000
    3.06 Acres

    Commercial Lot Near I-75

    Commercial land in a rapidly developing area near major routes.

    TBD SW COMMERCE DR, Lake City, FL 32025
    View details

    Explore Off-Market Properties in Mayo, FL

    Consider similar Off-Market properties in Mayo, FL. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    757 State Rd 51

    757 State Rd 51

    OFFICE BUILDING • 646 SF
    Value Estimation
    $2,200,000
    757 State Rd 51, Mayo, FL 32066-6609
    View details
    4485 County Rd 53

    4485 County Rd 53

    OFFICE BUILDING • 4,296 SF
    Value Estimation by Request
    4485 County Rd 53, Mayo, FL 32066-2834
    View details
    157 Main St

    157 Main St

    OFFICE BUILDING • 4,631 SF
    Value Estimation by Request
    157 Main St, Mayo, FL 32066-4808
    View details
    110 Fletcher Ave

    110 Fletcher Ave

    OFFICE BUILDING • 1,597 SF
    Value Estimation by Request
    110 Fletcher Ave, Mayo, FL 32066-4550
    View details
    126 Land Ave

    126 Land Ave

    OFFICE BUILDING • 1,452 SF
    Value Estimation by Request
    126 Land Ave, Mayo, FL 32066-4824
    View details
    311 Crawford St

    311 Crawford St

    OFFICE BUILDING • 4,266 SF
    Value Estimation by Request
    311 Crawford St, Mayo, FL 32066-4611
    View details
    306 County Rd 300

    306 County Rd 300

    OFFICE BUILDING • 1,200 SF
    Value Estimation by Request
    306 County Rd 300, Mayo, FL 32066
    View details
    258 Main St

    258 Main St

    PROFESSIONAL BUILDING • 1,998 SF
    Value Estimation by Request
    258 Main St, Mayo, FL 32066
    View details
    4573 County Rd 53

    4573 County Rd 53

    OFFICE BUILDING • 1,777 SF
    Value Estimation by Request
    4573 County Rd 53, Mayo, FL 32066-2818
    View details
    135 Bloxham St

    135 Bloxham St

    OFFICE BUILDING • 814 SF
    Value Estimation by Request
    135 Bloxham St, Mayo, FL 32066
    View details
    Cr 53

    Cr 53

    OFFICE BUILDING • 6,688 SF
    Value Estimation by Request
    Cr 53, Mayo, FL 32066
    View details
    207 Main St

    207 Main St

    OFFICE BUILDING • 1,494 SF
    Value Estimation by Request
    207 Main St, Mayo, FL 32066
    View details
    226 Main St

    226 Main St

    OFFICE BUILDING • 1,074 SF
    Value Estimation by Request
    226 Main St, Mayo, FL 32066
    View details
    710 Main St

    710 Main St

    PROFESSIONAL BUILDING • 8,783 SF
    Value Estimation by Request
    710 Main St, Mayo, FL 32066-4127
    View details
    348 Fletcher Ave

    348 Fletcher Ave

    OFFICE BUILDING • 3,082 SF
    Value Estimation by Request
    348 Fletcher Ave, Mayo, FL 32066-4502
    View details
    224 Park St

    224 Park St

    Individual retail properties • 1,080 SF
    Value Estimation by Request
    224 Park St, Mayo, FL 32066
    View details
    115 Park St

    115 Park St

    OFFICE BUILDING • 1,000 SF
    Value Estimation by Request
    115 Park St, Mayo, FL 32066
    View details
    118 Monroe Ave

    118 Monroe Ave

    OFFICE BUILDING • 614 SF
    Value Estimation by Request
    118 Monroe Ave, Mayo, FL 32066
    View details
    116 Monroe Ave

    116 Monroe Ave

    OFFICE BUILDING • 770 SF
    Value Estimation by Request
    116 Monroe Ave, Mayo, FL 32066-4710
    View details
    262 Main St

    262 Main St

    OFFICE BUILDING • 2,500 SF
    Value Estimation by Request
    262 Main St, Mayo, FL 32066
    View details
    874 Main St

    874 Main St

    PROFESSIONAL BUILDING • 2,328 SF
    Value Estimation by Request
    874 Main St, Mayo, FL 32066-5600
    View details
    974 Main St

    974 Main St

    PROFESSIONAL BUILDING • 2,560 SF
    Value Estimation by Request
    974 Main St, Mayo, FL 32066-5631
    View details
    120 Main St

    120 Main St

    OFFICE BUILDING • 14,804 SF
    Value Estimation by Request
    120 Main St, Mayo, FL 32066-4095
    View details

    Mayo, FL Office Properties & Spaces Investment Opportunities Market Analysis

    Explore 31 office properties & spaces for sale in Mayo, FL on our real estate platform. These investment opportunities span a total of 635,726 square feet of properties for sale, with an estimated market value of $5,615,000.

    Sale prices for office spaces in Mayo, FL start at $90,000, averaging $802,142, and reaching up to $2,200,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Most Searched ZIP Codes in Mayo, FL

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