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San Antonio, TX Office Spaces for Lease

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649 properties
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Two-Story Flex Industrial Building
Two-Story Flex Industrial Building

2110 MANNIX DR SAN ANTONIO TX 78217, San Antonio, TX 78217

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15,451 sqft 0.56 AC lot

Vacant two-story flex building with office and warehouse space, 18' clear height, and drive-in access.

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Creative Urban Office Space
Creative Urban Office Space

816 Camaron St, San Antonio, TX 78212

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1,740 sqft

Creative office space with high ceilings and free covered parking near VIA Metropolitan Service.

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Office Building in Innovation District
Office Building in Innovation District

1305 E Houston St, San Antonio, TX 78205

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7,730 sqft

Redeveloped Merchants Ice Building office space within the VelocityTX Innovation Center campus on San Antonio’s east side.

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Two-Tower Office Building
Two-Tower Office Building

901 NE Loop 410 Access Rd, San Antonio, TX 78217

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1,861 sqft

Two nine-story office towers totaling 185,082 square feet, minutes from San Antonio International Airport.

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Medical Office Space with Flexible Layouts
Medical Office Space with Flexible Layouts

5372 Fredericksburg Rd, San Antonio, TX 78229

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16,241 sqft

Renovated finishes and upgraded mechanical systems support a professional medical office setting.

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Office Building Lease Space
Office Building Lease Space

112 East Pecan Street, San Antonio, TX 78205

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33,987 sqft

Office leasing option at 112 East Pecan Street in San Antonio for businesses seeking dedicated workspace.

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Flex Space With Workshop
Flex Space With Workshop

1903 Air Lawn St, San Antonio, TX 78227

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4,800 sqft

I-1-zoned commercial building with office, reception, conference, workshop, and parking areas.

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Downtown Office Floor Space
Downtown Office Floor Space

111 W Houston St, San Antonio, TX 78205

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20,354 sqft

Available now floors 28–30, with additional floor 31 space scheduled for Q3 2026, plus negotiable furniture.

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Medical Office Space
Medical Office Space

150 E Sonterra Blvd, San Antonio, TX 78258

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923 sqft

Physician-oriented setting near Methodist and North Central Baptist Hospitals, with a bank located on the lower level.

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Professional Office Unit
Professional Office Unit

2211 BUENA VISTA ST, San Antonio, TX 78207

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165 sqft

Compact office accommodation with shared amenities and on-site parking.

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Renovated Medical Office Space
Renovated Medical Office Space

5430 Fredericksburg Rd, San Antonio, TX 78229

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11,444 sqft

Medical office space with flexible floor plans and renovated exterior and interior finishes, plus upgraded mechanical systems.

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Renovated Office Space
Renovated Office Space

5805 Callaghan Rd, San Antonio, TX 78228

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1,067 sqft

Recently renovated office space with easy access to Loop 410 and I-10, near The Medical Center.

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Two-Story Medical Office Space
Two-Story Medical Office Space

540 Oak Centre Dr, San Antonio, TX 78258

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1,248 sqft

Two-story property with wood and marble finishes and parking at a 4/1000 ratio.

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Two-Tower Office Complex
Two-Tower Office Complex

901 NE Loop 410 Access Rd, San Antonio, TX 78217

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917 sqft

Alamo Towers offers office space across two nine-story towers with a total footprint of 185,082 square feet.

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Office Units Near Airport
Office Units Near Airport

8626-8700 Tesoro Drive, San Antonio, TX 78217

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52,024 sqft

Office units arranged within an established two-tower office setting near Loop 410 and San Antonio International Airport.

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Keycard-Controlled 24/7 Office Units
Keycard-Controlled 24/7 Office Units

18402 US Hwy 281 N, San Antonio, TX 78259

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1,942 sqft

Secure, keycard-controlled access provides 24/7 entry, with on-site management, a furnished conference room, and surface parking for tenants.

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Office Unit with Signage
Office Unit with Signage

4216 Thousand Oaks Drive, San Antonio, TX 78217

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2,881 sqft

Office space includes signage availability at a signalized intersection.

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Retail Space with Split Potential
Retail Space with Split Potential

22010 Scenic Loop Rd, San Antonio, TX 78255

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12,400 sqft

Large retail/medical-oriented space offers flexibility to serve one tenant or be divided into inline shop areas.

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Furnished Office Campus
Furnished Office Campus

8000 W Interstate 10, San Antonio, TX 78229

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6,800 sqft 16.00 AC lot

Three-building furnished office campus with abundant parking, covered walkways, and 24/7 security.

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High-Floor Office Suites
High-Floor Office Suites

111 W Houston St, San Antonio, TX 78205

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17,681 sqft

Flexible office tenancy with individual or multi-floor space, and select floors available now through 2026.

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Renovated Medical Office Space
Renovated Medical Office Space

5430 Fredericksburg Rd, San Antonio, TX 78229

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2,678 sqft

Flexible medical office floor plans with renovated interior and exterior finishes and upgraded mechanical systems.

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Three-Story Office Building
Three-Story Office Building

13333 Blanco Road, San Antonio, TX 78216

$22 SF/Yr

Three-story office building with covered and surface parking, plus signage opportunities on Blanco Road.

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Office Building with On-Site Surgery Center
Office Building with On-Site Surgery Center

423 TREELINE PARK, San Antonio, TX 78209

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6,174 sqft

Three-story office and medical building with an on-site surgery center and reserved covered parking.

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Move-In Ready Office Suites
Move-In Ready Office Suites

8123 Datapoint Drive, San Antonio, TX 78229

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10,349 sqft

Move-in ready office space includes a newly built suite with direct lobby access plus a full second-floor layout.

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