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Mission, TX Office Spaces for Lease

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46 properties
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Remodeled Office Suite with Private Offices
Updated: Jul 6
Remodeled Office Suite with Private Offices

103 E 30th Street, Mission, TX 78574

$2,500/Mo
6,028 sqft 0.29 AC lot
Remodeled 2,000 SF commercial office space for lease
Layout includes a spacious open area, plus 2 private offices
2 bathrooms
Year built: 1998
Accessible approach with ramp and special needs parking features
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Mixed-Use Plaza-Corner Building
Updated: Apr 15
Mixed-Use Plaza-Corner Building

1352 E 1st Street, Mission, TX 78572

$3,366/Mo
3,366 sqft 0.61 AC lot
3,366 square feet of mixed‑use commercial space
0.6074‑acre site within a larger plaza
Corner position at Bryan Road and 1st Street
Near Expressway 83 in Mission
Built in 2006
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Office Units for Medical Use
Office Units for Medical Use

2134 E Griffin Parkway, Mission, TX 78572

$2,000/Mo
2,970 sqft 0.22 AC lot

Established commercial property configured for office or medical-office operations in Mission, Texas.

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Medical Office Suite with Covered Patio
Medical Office Suite with Covered Patio

12-909 Business Park Dr, Mission, TX 78572

$9,671/Mo
6,067 sqft

Medical suite features an open area, offices, restrooms, kitchen, storage, and covered patio for day-to-day patient care.

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First-Floor Office Suite
First-Floor Office Suite

1112 E Griffin Parkway, Mission, TX 78572

$2,750/Mo
10,584 sqft

Office suite within a landscaped professional development with access from Bryan Road and Griffin Parkway.

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Office Suite with Balcony
Office Suite with Balcony

1112 Griffin Parkway, Mission, TX 78572

$2,750/Mo
1,350 sqft

Professional space offers dual access and views toward landscaped fountain gardens and a golf course.

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Second-Floor Office Suite
Second-Floor Office Suite

1022 E Griffin Parkway W, Mission, TX 78572

$2,700/Mo
1,996 sqft 0.12 AC lot

Suite 207B includes courtyard and golf course views with access from Bryan Rd and Griffin Parkway.

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Utilities-Included Office Suite
Utilities-Included Office Suite

2419 Brock Street # A, Mission, TX 78572

$1,600/Mo
1,232 sqft

Office space with flexible layout and included water and trash, with electricity and Wi-Fi paid by the tenant.

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Medical Office Suite with Balcony
Medical Office Suite with Balcony

D-1112 W Griffin Pkwy, Mission, TX 78572

$2,750/Mo
1,350 sqft

Fully finished second-floor suite includes a balcony overlooking courtyard and fountain gardens with golf course views.

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Turnkey Second-Floor Office Suite
Turnkey Second-Floor Office Suite

207b-1022 E Griffin Pkwy, Mission, TX 78572

$2,700/Mo
1,996 sqft

Turnkey office suite on the second floor with courtyard and golf course views.

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Retail Suites with Flexible Build-Out
Retail Suites with Flexible Build-Out

650-4001 S Shary Rd, Mission, TX 78572

$1,680/Mo
26,329 sqft

Multi-suite retail plaza with parking and nearby retail, dining, medical, and residential development.

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Multi-Suite Retail Space
Multi-Suite Retail Space

300-4001 S Shary Rd, Mission, TX 78572

$2,153/Mo
26,329 sqft

Multiple suite configurations support retail, office, salon, studio, and boutique service uses.

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Remodeled Church Facility With Offices
Remodeled Church Facility With Offices

103 E 30th St, Mission, TX 78574

$2,700/Mo
6,028 sqft

Flexible interior combines open workspace, private offices, and two restrooms.

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Retail Plaza with Flexible Build-Out
Retail Plaza with Flexible Build-Out

350-4001 S Shary Rd, Mission, TX 78572

$2,198/Mo
26,329 sqft

Newly available suites offer adaptable layouts, parking, and prominent exposure for retail and professional service businesses.

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Retail Space in Commercial Plaza
Retail Space in Commercial Plaza

250-4001 S Shary Rd, Mission, TX 78572

$2,206/Mo
26,329 sqft

Multiple suite sizes support retail, professional office, salon, studio, and boutique service uses.

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Retail Suite with Flexible Build-Out
Retail Suite with Flexible Build-Out

700-4001 S Shary Rd, Mission, TX 78572

$1,675/Mo
1,197 sqft

Adaptable commercial space with on-site parking and exposure along S Shary Rd.

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Retail Plaza Suites
Retail Plaza Suites

150-4001 S Shary Rd, Mission, TX 78572

$2,836/Mo
26,329 sqft

Commercial units offer flexible build-out potential, parking, and visibility along S Shary Rd.

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Retail Suite with Flexible Build-Out
Retail Suite with Flexible Build-Out

450-4001 S Shary Rd, Mission, TX 78572

$2,052/Mo
1,466 sqft

Retail space with parking and nearby retail, restaurants, medical offices, and residential development.

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Retail Space with Flexible Build-Out
Retail Space with Flexible Build-Out

200-4001 S Shary Rd, Mission, TX 78572

$1,586/Mo
1,133 sqft

Commercial suites at 4001 S Shary Rd offer parking and build-out flexibility for varied business formats.

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Medical Office Suite With Private Offices
Medical Office Suite With Private Offices

3-909 Business Park Dr, Mission, TX 78572

$4,675/Mo
2,933 sqft

Medical suite within a multi-tenant building near Interstate 2 and Mission Regional Medical Center.

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Upstairs Spa and Office Suite
Upstairs Spa and Office Suite

600 S Shary Road, Mission, TX 78572

$2,340/Mo

Upstairs suite with private rooms, reception area, work space, and restroom.

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Full-Service Coworking Office Suite
Full-Service Coworking Office Suite

2515 Colorado Street # 2, Mission, TX 78572

$500/Mo per office

Private office and conference access within a full-service coworking setting with 24/7 member access and private tenant entry.

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Medical Office Suite with Exam Rooms
Medical Office Suite with Exam Rooms

4b-900 Plaza Dr, Mission, TX 78572

$3,311/Mo
2,077 sqft

Medical suite includes dedicated offices, restrooms, and utility areas.

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Multi-Tenant Medical Office Space
Multi-Tenant Medical Office Space

900 Plaza Dr & 909 Business Park Dr, Mission, TX 78572

$15 SF/Yr

Medical specialties are consolidated within a professional office setting near Interstate 2 and Mission Regional Medical Center.

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Mission, TX Office Spaces Lease Rates & Market Statistics

Explore 46 Office Spaces for lease in Mission, TX on Realmo, a commercial real estate exchange covering the Mission area. The current inventory totals 402,356 square feet of properties — an average of ~8,750 SF per listing.

Office Spaces lease rates in Mission range from $1.00 SF/Yr at the entry level to $24.44 SF/Yr at the top of the market, averaging $12.52 SF/Yr. That's a 24x spread between entry-level and premium space, making side-by-side comparison of asking rents and lease terms essential. At $12.52 SF/Yr, the local average runs 48% below Texas's state average of $23.90 SF/Yr.

Mission accounts for 12% of the 375 office spaces currently available across Hidalgo County, where nearby markets include Mcallen and Edinburg. By space type, the market includes 41 office units and 11 medical office space listings — office units typically offer the lowest entry point, while medical office space commands the highest rates.

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