Mission, TX Office Spaces for Rent & Lease

Updated: Oct 5

Finished Office Suite

1112 E Griffin Parkway, Mission, TX 78572

$2,400/Mo

2,200 sqft 1.08 AC lot

2,200‑square‑foot office suite, identified as Suite 1112‑C
Fully finished interior
Access from Bryan Road and Griffin Parkway
Second‑story balcony overlooking fountain gardens and golf course views
Courtyard on site

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Updated: Jul 6

Remodeled Office Suite

103 E 30th Street, Mission, TX 78574

$2,500/Mo

6,028 sqft 0.29 AC lot

2,000‑square‑foot remodeled office suite
Open interior area with 2 private offices
2 bathrooms included in the suite
Accessible approach with ramp
Located at 103 E 30th Street in Mission

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Medical Office Suite with Patient Rooms

2134 E Griffin Parkway, Mission, TX 78572

$2,000/Mo

2,970 sqft 0.22 AC lot

Configured with clinical rooms, private offices, reception, storage, and a break area.

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Flex Space with Warehouse and Office

2504 W Expressway 83, Mission, TX 78572

$7,420/Mo

7,420 sqft

Frontage along Expressway 83 supports a combined warehouse and finished office configuration.

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Mixed-Use Plaza-Corner Building

1352 E 1st Street, Mission, TX 78572

$3,366/Mo

3,366 sqft 0.61 AC lot

Commercial space supports office, medical, educational, retail, and restaurant uses.

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Finished Professional Office Suite

1112 Griffin Parkway, Mission, TX 78572

$2,250/Mo

1,350 sqft 1.08 AC lot

Fully finished office space with dual access from Bryan Rd and Griffin Parkway.

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First-Floor Office Suite

1112 E Griffin Parkway, Mission, TX 78572

$2,750/Mo

10,584 sqft 1.08 AC lot

C3-zoned office space with direct access from Bryan Rd and Griffin Parkway.

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Finished Office Suite

C-1112 E Griffin Parkway, Mission, TX 78572

$2,400/Mo

2,200 sqft

Located in Advanced Medical Arts Center, with dual access from Bryan Road and Griffin Parkway.

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Medical Office Suite with Covered Patio

12-909 Business Park Dr, Mission, TX 78572

$9,671/Mo

6,067 sqft

Medical suite features an open area, offices, restrooms, kitchen, storage, and covered patio for day-to-day patient care.

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Remodeled Church Facility With Offices

103 E 30th St, Mission, TX 78574

$2,500/Mo

6,028 sqft

Flexible interior combines open workspace, private offices, and two restrooms.

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Medical Office Suite with Balcony

D-1112 E Griffin Pkwy, Mission, TX 78572

$2,750/Mo

10,584 sqft

Fully finished second-floor suite includes a balcony overlooking courtyard and fountain gardens with golf course views.

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Retail Suites with Flexible Build-Out

650-4001 S Shary Rd, Mission, TX 78572

$1,680/Mo

26,329 sqft

Multi-suite retail plaza with parking and nearby retail, dining, medical, and residential development.

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Medical Office Space with Offices

7-909 Business Park Dr, Mission, TX 78572

$3,905/Mo

2,450 sqft

A medical suite with an open area, six offices, and two restrooms within a multi-tenant healthcare setting.

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Multi-Suite Retail Space

300-4001 S Shary Rd, Mission, TX 78572

$2,153/Mo

26,329 sqft

Multiple suite configurations support retail, office, salon, studio, and boutique service uses.

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Retail Plaza with Flexible Build-Out

350-4001 S Shary Rd, Mission, TX 78572

$2,198/Mo

26,329 sqft

Newly available suites offer adaptable layouts, parking, and prominent exposure for retail and professional service businesses.

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Retail Space in Commercial Plaza

250-4001 S Shary Rd, Mission, TX 78572

$2,206/Mo

26,329 sqft

Multiple suite sizes support retail, professional office, salon, studio, and boutique service uses.

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Retail Suite with Flexible Build-Out

700-4001 S Shary Rd, Mission, TX 78572

$1,675/Mo

1,197 sqft

Adaptable commercial space with on-site parking and exposure along S Shary Rd.

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Retail Plaza Suites

150-4001 S Shary Rd, Mission, TX 78572

$2,836/Mo

26,329 sqft

Commercial units offer flexible build-out potential, parking, and visibility along S Shary Rd.

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Retail Suite with Flexible Build-Out

450-4001 S Shary Rd, Mission, TX 78572

$2,052/Mo

1,466 sqft

Retail space with parking and nearby retail, restaurants, medical offices, and residential development.

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Retail Space with Flexible Build-Out

200-4001 S Shary Rd, Mission, TX 78572

$1,586/Mo

1,133 sqft

Commercial suites at 4001 S Shary Rd offer parking and build-out flexibility for varied business formats.

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Medical Office Suite With Private Offices

3-909 Business Park Dr, Mission, TX 78572

$4,675/Mo

2,933 sqft

Medical suite within a multi-tenant building near Interstate 2 and Mission Regional Medical Center.

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Medical Office Suite with Exam Rooms

2-900 Plaza Dr, Mission, TX 78572

$6,088/Mo

3,819 sqft

Configured for clinical operations with private offices, exam rooms, restrooms, and dedicated support areas.

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Upstairs Spa and Office Suite

600 S Shary Road, Mission, TX 78572

$2,340/Mo

Upstairs suite with private rooms, reception area, work space, and restroom.

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Full-Service Coworking Office Suite

2515 Colorado Street # 2, Mission, TX 78572

$500/Mo per office

Private office and conference access within a full-service coworking setting with 24/7 member access and private tenant entry.

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Mission, TX Office Spaces Lease Rates & Market Statistics

Explore 36 Office Spaces for lease in Mission, TX on Realmo, a commercial real estate exchange covering the Mission area. The current inventory totals 392,674 square feet of properties — an average of ~10,900 SF per listing.

Office Spaces lease rates in Mission range from $1.00 SF/Yr at the entry level to $20 SF/Yr at the top of the market, averaging $10.43 SF/Yr. That's a 20x spread between entry-level and premium space, making side-by-side comparison of asking rents and lease terms essential. At $10.43 SF/Yr, the local average runs 57% below Texas's state average of $24.28 SF/Yr.

Mission accounts for 10% of the 347 office spaces currently available across Hidalgo County, where nearby markets include Mcallen and Edinburg. By space type, the market includes 33 office units, 12 medical office space listings and 3 coworking space listings.