Mission, TX Medical Office Space for Rent & Lease

Updated: Oct 5

Finished Office Suite

1112 E Griffin Parkway, Mission, TX 78572

$2,400/Mo

2,200 sqft 1.08 AC lot

2,200‑square‑foot office suite, identified as Suite 1112‑C
Fully finished interior
Access from Bryan Road and Griffin Parkway
Second‑story balcony overlooking fountain gardens and golf course views
Courtyard on site

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Updated: Aug 26

Medical Office Suite with Patient Rooms

2134 E Griffin Parkway, Mission, TX 78572

$2,000/Mo

2,970 sqft 0.22 AC lot

2,970 square feet of medical office space
Three patient rooms, each equipped with a sink
Two private office spaces plus a computer niche
Glassed‑in reception area
Rear storage room and break room

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Medical Office Suite with Covered Patio

12-909 Business Park Dr, Mission, TX 78572

$9,671/Mo

6,067 sqft

Medical suite features an open area, offices, restrooms, kitchen, storage, and covered patio for day-to-day patient care.

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Medical Office Suite with Balcony

D-1112 E Griffin Pkwy, Mission, TX 78572

$2,750/Mo

10,584 sqft

Fully finished second-floor suite includes a balcony overlooking courtyard and fountain gardens with golf course views.

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Upstairs Spa and Office Suite

600 S Shary Road, Mission, TX 78572

$2,340/Mo

Upstairs suite with private rooms, reception area, work space, and restroom.

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Medical Office Space with Offices

7-909 Business Park Dr, Mission, TX 78572

$3,905/Mo

2,450 sqft

A medical suite with an open area, six offices, and two restrooms within a multi-tenant healthcare setting.

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Medical Office Suite With Private Offices

3-909 Business Park Dr, Mission, TX 78572

$4,675/Mo

2,933 sqft

Medical suite within a multi-tenant building near Interstate 2 and Mission Regional Medical Center.

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Medical Office Suite with Exam Rooms

2-900 Plaza Dr, Mission, TX 78572

$6,088/Mo

3,819 sqft

Configured for clinical operations with private offices, exam rooms, restrooms, and dedicated support areas.

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Medical Office Suite with Exam Rooms

4b-900 Plaza Dr, Mission, TX 78572

$3,311/Mo

2,077 sqft

Medical suite includes dedicated offices, restrooms, and utility areas.

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Multi-Tenant Medical Office Space

900 Plaza Dr & 909 Business Park Dr, Mission, TX 78572

$15 SF/Yr

Medical specialties are consolidated within a professional office setting near Interstate 2 and Mission Regional Medical Center.

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Two-Level Medical Center

305 E Expressway 83, Mission, TX 78572

Contact for pricing

Healthcare lease space includes elevator access, a separate entrance, and shared first-floor reception within an established clinical facility.

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Medical Office Suite with Exam Rooms

1-a-900 Plaza Dr, Mission, TX 78572

$1,637/Mo

1,027 sqft

Two exam rooms, a private office, and a bathroom support clinical operations.

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Based on your search, we've compiled 21 Potential Opportunities for your consideration. Besides 12 Active listings in Mission, TX, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 5 Properties for Sales.

Medical Office Space for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Remodeled Medical Office Space

600 S Bicentennial Boulevard, Mcallen, TX 78501

$18 SF/Yr

15,000 sqft

Configured with private offices, exam rooms, radiology setup, and two nurses’ stations.

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Remodeled Medical Office Facility

600 S Bicentennial Boulevard, Mcallen, TX 78501

$18.60 SF/Yr

29,232 sqft

Updated healthcare facility with exam rooms, private offices, and radiology infrastructure.

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Medical Office Space Near Retail Anchors

155 W Mile 3, Palmhurst, TX 78573

$2,333-$2,416/Mo

Two office suites support medical, professional service, beauty, insurance, and counseling uses.

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Finished Office Suite

123 W Mile 3 Rd, Palmhurst, TX 78573

Contact for pricing

1,450 sqft

Well-finished office space available for professional and medical-related uses in a neighboring clinic setting.

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Similar Spaces for Sale in Mission, TX

Consider Similar Space for Sale. We found 5 Spaces matching your search parameters.

Medical Office Building with Exam Rooms

1022 E Griffin Parkway, Mission, TX 78572

$585,000

2,400 sqft 0.17 AC lot

Configured with reception, private offices, support areas, and an open-plan workspace for healthcare-related use.

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Medical Office Space with Balcony

1022 E Griffin Parkway, Mission, TX 78572

$305,000

4,112 sqft 0.19 AC lot

Partial suites provide a flexible interior canvas within a professional office development with courtyard and balcony features.

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Medical Office Building

104-b-1022 E Griffin Pkwy, Mission, TX 78572

$585,000

2,400 sqft

Medical office building with a reception lobby, exam/work stations, and both full and half bathrooms.

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Downtown Mission Investment Opportunity

Mission, TX 78572

$695,000

3,581 sqft 0.24 AC lot

Income-producing property with established tenants in Downtown Mission.

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Renovated Medical Office Suite

101-1300 S Bryan Rd, Mission, TX 78572

$395,000

2,925 sqft

Updated professional space with a functional layout for healthcare, wellness, or office users.

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Mission, TX Medical Office Space Lease Rates & Market Statistics

Explore 12 Medical Office Space listings for lease in Mission, TX on Realmo, a commercial real estate exchange covering the Mission area. The current inventory totals 34,127 square feet of properties — an average of ~2,850 SF per listing.

Medical Office Space lease rates in Mission range from $3.12 SF/Yr at the entry level to $19.13 SF/Yr at the top of the market, averaging $11.68 SF/Yr. That's a 6x spread between entry-level and premium space, making side-by-side comparison of asking rents and lease terms essential. At $11.68 SF/Yr, the local average runs 52% below Texas's state average of $24.22 SF/Yr.

Mission accounts for 15% of the 79 medical office space listings currently available across Hidalgo County, where nearby markets include Mcallen and Edinburg. Medical Office Space listings make up 34% of the 35 Office Spaces currently for lease in Mission, with asking rates averaging $11.68 SF/Yr — 12% above the citywide Office Spaces average of $10.43 SF/Yr. Tenants comparing options may also consider Office Units (32 listings) and Coworking space (3 listings) elsewhere in the Mission market.