Mission, TX Medical Office Space for Lease

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La Joya, TX Palmview, TX Palmhurst, TX Mcallen, TX Alton, TX Hidalgo, TX Penitas, TX Pharr, TX

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Updated: Aug 26

Medical Office Suite with Patient Rooms

2134 E Griffin Parkway, Mission, TX 78572

$2,000/Mo

2,970 sqft 0.22 AC lot

2,970 square feet of medical office space
Three patient rooms, each equipped with a sink
Two private office spaces plus a computer niche
Glassed‑in reception area
Rear storage room and break room

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Updated: May 7

Medical Office Suite with Covered Patio

12-909 Business Park Dr, Mission, TX 78572

$9,671/Mo

6,067 sqft

Medical suite totals 6,067 SF in The Health Quarters multi‑tenant medical office building
Suite layout includes 1 spacious open area plus 4 offices
Includes restrooms, a kitchen, and a storage room
Features a covered porch and a covered patio area
Building is near Interstate 2 and anchored by Mission Regional Medical Center in Mission, TX

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Medical Office Suite with Balcony

D-1112 E Griffin Pkwy, Mission, TX 78572

$2,750/Mo

10,584 sqft

Fully finished second-floor suite includes a balcony overlooking courtyard and fountain gardens with golf course views.

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Medical Office Space with Offices

7-909 Business Park Dr, Mission, TX 78572

$3,905/Mo

2,450 sqft

A medical suite with an open area, six offices, and two restrooms within a multi-tenant healthcare setting.

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Medical Office Suite With Private Offices

3-909 Business Park Dr, Mission, TX 78572

$4,675/Mo

2,933 sqft

Medical suite within a multi-tenant building near Interstate 2 and Mission Regional Medical Center.

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Medical Office Suite with Exam Rooms

2-900 Plaza Dr, Mission, TX 78572

$6,088/Mo

3,819 sqft

Configured for clinical operations with private offices, exam rooms, restrooms, and dedicated support areas.

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Upstairs Spa and Office Suite

600 S Shary Road, Mission, TX 78572

$2,340/Mo

Upstairs suite with private rooms, reception area, work space, and restroom.

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Medical Office Suite with Exam Rooms

4b-900 Plaza Dr, Mission, TX 78572

$3,311/Mo

2,077 sqft

Medical suite includes dedicated offices, restrooms, and utility areas.

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Multi-Tenant Medical Office Space

900 Plaza Dr & 909 Business Park Dr, Mission, TX 78572

$15 SF/Yr

Medical specialties are consolidated within a professional office setting near Interstate 2 and Mission Regional Medical Center.

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Two-Level Medical Center

305 E Expressway 83, Mission, TX 78572

Contact for pricing

Healthcare lease space includes elevator access, a separate entrance, and shared first-floor reception within an established clinical facility.

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Medical Office Suite with Exam Rooms

1-a-900 Plaza Dr, Mission, TX 78572

$1,637/Mo

1,027 sqft

Two exam rooms, a private office, and a bathroom support clinical operations.

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Medical Office Space Near Hospital

900 Plaza Drive # A #1-A, Mission, TX 78572

Contact for pricing

4,027 sqft

Multi-tenant medical office building near Mission Regional Medical Center.

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Strip Center with Medical Office

3401 W Mile 5 Rd, Mission, TX 78574

Contact for pricing

2,500 sqft

Three-unit strip center ideal for medical, retail, or office.

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Based on your search, we've compiled 31 Potential Opportunities for your consideration. Besides 13 Active listings in Mission, TX, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 14 Properties for Sales.

Medical Office Space for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Remodeled Medical Office Space

600 S Bicentennial Boulevard, Mcallen, TX 78501

$18 SF/Yr

15,000 sqft

Configured with private offices, exam rooms, radiology setup, and two nurses’ stations.

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Remodeled Medical Office Facility

600 S Bicentennial Boulevard, Mcallen, TX 78501

$18.60 SF/Yr

29,232 sqft

Updated healthcare facility with exam rooms, private offices, and radiology infrastructure.

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Medical Office Space Near Retail Anchors

155 W Mile 3, Palmhurst, TX 78573

$2,333-$2,416/Mo

Two office suites support medical, professional service, beauty, insurance, and counseling uses.

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Finished Office Suite

123 W Mile 3 Rd, Palmhurst, TX 78573

Contact for pricing

1,450 sqft

Well-finished office space available for professional and medical-related uses in a neighboring clinic setting.

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Similar Spaces for Sale in Mission, TX

Consider Similar Space for Sale. We found 14 Spaces matching your search parameters.

Medical Office Building with Exam Rooms

1022 E Griffin Parkway, Mission, TX 78572

$600,000

2,400 sqft 0.17 AC lot

Configured with reception, private offices, support areas, and an open-plan workspace for healthcare-related use.

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Medical Office Building

104-b-1022 E Griffin Pkwy, Mission, TX 78572

$600,000

2,400 sqft

Medical office building with a reception lobby, exam/work stations, and both full and half bathrooms.

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Medical Office Space with Balcony

1022 E Griffin Parkway, Mission, TX 78572

$305,000

4,112 sqft 0.19 AC lot

Partial suites provide a flexible interior canvas within a professional office development with courtyard and balcony features.

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Renovated Medical Office Suite

101-1300 S Bryan Rd, Mission, TX 78572

$399,000

2,925 sqft

Updated professional space with a functional layout for healthcare, wellness, or office users.

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Renovated Medical Office Suite

1300 S Bryan Road Unit 101, Mission, TX 78572

$399,000

2,925 sqft

Updated suite includes central air, paved parking, and a layout suited to medical or professional office use.

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Medical Office Space

2134 Griffin Parkway, Mission, TX 78572

Contact for pricing

2,970 sqft

Established medical office property with paved on-site parking and direct access from a city road.

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Medical Office Suites with Dual Entry

1022 E Griffin Parkway Unit 205 (Par, Mission, TX 78572

$305,000

4,112 sqft

Flexible medical office suites in a professional center with accessible entrances and shared courtyard amenities.

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Flexible-Layout Office Unit

1601 Griffin Parkway, Mission, TX 78572

Contact for pricing

1,450 sqft

Office suite with a lobby, private offices, kitchen area, and storage space within Shary Gardens Plaza.

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Freestanding Medical Office Building

10400 N 103rd Street, Mission, TX 78573

Contact for pricing

5,280 sqft 0.34 AC lot

Freestanding two-unit medical/office building with ample customer parking and corner exposure.

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Professional Office Building

600 E Griffin Parkway, Mission, TX 78572

Contact for pricing

7,429 sqft

Prestige Plaza is a 7,429-sf professional office building with current mixed occupancy, including a dental tenant.

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Medical Office Suite with Exam Rooms

900 Plaza Drive, Mission, TX 78572

Contact for pricing

3,819 sqft

Configured for clinical operations with private offices, patient rooms, restrooms, a lobby, lounge, and file storage.

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Mission, TX Medical Office Space Lease Rates & Market Statistics

Explore 13 Medical Office Space listings for lease in Mission, TX on Realmo, a commercial real estate exchange covering the Mission area. The current inventory totals 38,454 square feet of properties — an average of ~2,950 SF per listing.

Medical Office Space lease rates in Mission range from $3.12 SF/Yr at the entry level to $19.13 SF/Yr at the top of the market, averaging $11.33 SF/Yr. That's a 6x spread between entry-level and premium space, making side-by-side comparison of asking rents and lease terms essential. At $11.33 SF/Yr, the local average runs 53% below Texas's state average of $23.86 SF/Yr.

Mission accounts for 18% of the 71 medical office space listings currently available across Hidalgo County, where nearby markets include Edinburg and Mcallen. Medical Office Space listings make up 27% of the 48 Office Spaces currently for lease in Mission, with asking rates in line with the citywide Office Spaces average. Tenants comparing options may also consider Office Units (43 listings) elsewhere in the Mission market.

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