League City, TX Office Spaces for Lease

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South Shore

2600 Shores Blvd, Unit 300, League City, TX 77573

16 available spaces from 11 to 1,992 sqft

$129-$25,211/Mo

(972) 764-8885

Flexible workspace in South Shore. Book a tour & get info

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Updated: Jul 31, 2025

High-Visibility Retail and Flex Space

2403 Gulf Freeway S, League City, TX

$24 SF/Yr

10,000 sqft

Prime I‑45 visibility in a high‑traffic location near major retailers.
Strategic future access to SH 99 with designated access point less than a mile away.
Newly built 10,000 SF high‑impact retail and flex space suitable for office, retail, or medical use; can be subdivided.
Convenient access to major thoroughfares within a 10‑mile radius.
Proximity to Houston's Downtown and the #1 Medical Center in the World (25 miles).

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Updated: May 1

Warehouse with Climate-Controlled Office

2227 Gulf Fwy S, League City, TX 77573

$18 SF/Yr

Approximately 9,000 SF warehouse with two overhead doors plus about 12,400 SF climate‑controlled showroom and office space
Office/showroom includes multiple private offices, restrooms, and a dedicated breakroom
Warehouse has two (2) overhead doors (16' wide x 14' high) with ~16' clear height and up to 19' max ceiling height
Set on ~1.97 acres with a partially stabilized rear yard for truck maneuvering or outdoor storage
Available for lease or sale near I‑45, across from UTMB and MD Anderson, between League City Parkway and FM 646

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Professional/Medical Office Space Available

1455 FM 646 West, League City, TX 77573

$20 SF/Yr

Two-story office building near Gulf Freeway and UTMB Health.

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Office/Retail Space on High-Traffic Road

549 Egret Bay Boulevard, League City, TX 77573

$24 SF/Yr

Versatile space suitable for office or retail use.

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Office Space for Lease

951 FM 646 Rd, League City, TX 77573

Contact for pricing

5,000 sqft

Flexible office suites are available for lease, ranging from 1,000 to 5,000 square feet.

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Medical Office Space For Rent

3023 Marina Bay Dr -Ste 205, League City, TX 77573

$15 SF/Yr

Professional Center at South Shore Harbour, League City, TX

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Contemporary Office Suite with Views

2600 South Shore Boulevard, Suite300, League City, TX 77573

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Contemporary office suite with bright interior and marina views in a lakeside League City setting.

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Prime Medical and Retail Space

1320 W League City Pkwy, League City, TX 77573

$30 SF/Yr

Medical and retail spaces available in League City, Texas.

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League City Warehouses For Lease

1401 League City Pkwy, League City, TX 77573

$13.80 SF/Yr

Warehouses for lease in League City, Texas.

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League City Commercial Suites Available

1001 FM270, League City, TX 77573

$19 SF/Yr

3,300 sqft

Two suites available: dental office and open space.

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Based on your search, we've compiled 25 Potential Opportunities for your consideration. Besides 11 Active listings in League City, TX, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 6 Properties for Sales.

Office Spaces for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Office and Retail Space Available

451 FM 646 Rd, Dickinson, TX 77539

$22 SF/Yr

3,906 sqft

Office and retail spaces for rent, ranging from 1,000-3,906 SqFt.

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Medical Office Suite with Multiple Offices

305 Fm 517 Road East, Dickinson, TX 77539

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Leasing a medical-friendly office suite with reception, waiting areas, and 8+ private offices.

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Professional Office Space Available

1120 NASA Parkway, Houston, TX 77058

$20 SF/Yr

346 sqft

Quality, affordable office space in Clear Lake area.

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Professional Office Space Available

1120 E NASA Pkwy, Houston, TX 77058

$24.60 SF/Yr

Quality, affordable office space in a convenient Clear Lake location.

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Similar Spaces for Sale in League City, TX

Consider Similar Space for Sale. We found 6 Spaces matching your search parameters.

League City Commercial Opportunity

610-620 W Main Street, League City, TX

$2,500,000

1.44 AC lot

Prime commercial properties for sale in high-growth League City.

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Value-Add Office Building Opportunity

3027 Marina Bay Dr, League City, TX 77573

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57,939 sqft

Class B office building with value-add potential in Clear Lake.

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Commercial Land with High Visibility

1425 East Main Street, League City, TX 77573

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2 sqft 2.00 AC lot

Two-acre commercial land with frontage on two streets.

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Warehouse and Office Building

322 & 324 East Main Street, League City, TX 77573

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6,300 sqft

Mixed office and warehouse property with parking, building and monument signage, and visibility near major regional roadways.

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Executive Office Suite Building

550 Egret Bay Blvd, League City, TX 77573

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Seven executive office suites are offered with shared reception, conference room, kitchenettes, and restrooms.

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Prime Commercial Tract on FM 270

0 S FM 270, League City, TX 77573

$730,414

1.68 AC lot

1.6768 acre tract ideal for retail, office, restaurant.

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Potential Development Sites for Consideration

Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

Cleared Commercial Lot For Lease

943 King Arthur, New Braunfels, TX 78130

Contact for pricing

1.33-acre commercial lot in growing New Braunfels market.

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Prime Pad Site Near Baylor

722 S 7th Street, Waco, TX 76706

$105,000 SF/Yr

30,797 sqft

30,798 SF lot near Baylor and Magnolia Silos.

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Build-to-Suit Office Land Parcel

5637 Paluxy Dr, Tyler, TX 75703

$20,000/Mo

20,000 sqft

Land offering build-to-suit development flexibility for an office complex in South Tyler near major roadways.

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Build-to-Suit Retail/Office Buildings

5647 KPE Way, Tyler, TX 75703

$3,480/Mo

Retail or office build-to-suit with C-1 zoning and 99 parking spaces.

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League City, TX Office Spaces Market Trends and Statistics

Explore Office Spaces leasing options in League City, TX with 11 listings featured on our commercial real estate exchange. The current inventory includes 15,303 square feet of properties with an estimated lease value of $183.73 SF/Yr.

Estimated lease rates for Office Spaces in League City, TX begin at $19 SF/Yr, with an average of $61.24 SF/Yr and extend to $140.73 SF/Yr.

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