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Lake St Louis, MO Office Spaces for Lease

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33 properties
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Office Units with Covered Walkway
Office Units with Covered Walkway

1405 Jungermann Road, St Peters, MO 63376

Class A
$2,838/Mo
7–11 people  1,798 sqft  Built 2003  1.23 acres
Highway access

Two connected office suites with finished interiors, dedicated restrooms, utility rooms, and access to shared parking.

60 parking spaces  Covered walk way  Marque signage rights
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Medical Office Space with Wash Area
Medical Office Space with Wash Area

6180 Mexico Road, St Peters, MO 63376

$3,500/Mo
Built 1960  0.76 acres
Road access

Formerly configured for veterinary or grooming operations, with reception, treatment rooms, office areas, and a separate lower level.

Utilities to site
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Office Suite with Conference Rooms
Office Suite with Conference Rooms

O Fallon, MO 63368

$5,000/Mo
Built 1998  0.77 acres

The suite includes reception space, private offices, a break room, and dedicated storage.

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All-Brick Professional Office Building
All-Brick Professional Office Building

O Fallon, MO 63368

$18 SF/Yr
23–39 people  5,892 sqft  Built 2006  0.16 acres
Highway access  50%

All-brick office building with 2,946 SF available for lease near Hwy K and US 64 in Keaton Corporate Park.

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Lower-Level Retail Space
Lower-Level Retail Space

4053 N Saint Peters Parkway, St Peters, MO 63304

$960/Mo
Multi-tenant  960 sqft  Lower Level  Built 1992
Highway access

Flexible commercial suite with two open areas, a break room, office area, and ample surface parking.

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Office Unit with Monument Signage
Full service
Office Unit with Monument Signage

1234 Jungermann Road, St Peters, MO 63376

$14 SF/Yr
1 space  1,620 sqft  Built 1996  0.55 acres
4 private offices  1 meeting rooms  Highway access

Lower-level office space with multiple private rooms, a conference area, kitchenette, storage, and dedicated restroom.

Monument signage
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Furnished Private Coworking Office
Furnished Private Coworking Office

8-22 Richmond Center Ct, Saint Peters, MO 63376

Coworking
$1,200/Mo per office
1 person  260 sqft

Renovated workspace includes utilities, Wi-Fi, parking, and access to shared business amenities.

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Furnished Coworking Space
Furnished Coworking Space

1000 Mid Rivers Mall Drive Conference, St Peters, MO 63376

Coworking
$129 SF/Yr
35–58 people  8,800 sqft

Furnished offices provide meeting, mailing, and shared workplace services.

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Office Suite with Workstations
Modified gross
Office Suite with Workstations

4053 N Saint Peters Parkway #4053C-2, St Peters, MO 63304

$800/Mo
78–130 people  19,600 sqft  Built 1992
Highway access  C-3

C-3-zoned office space comes with removable workstations and access to Hwy 94 and I-364.

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Office Unit with Workstations
Office Unit with Workstations

4053 N Saint Peters Parkway 4053c-2, St Peters, MO 63304

$800/Mo
Built 1992

C-3-zoned office space with convenient access to Hwy 94 and I-364.

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Office Unit with Conference Room
Full service
Office Unit with Conference Room

St Peters, MO 63376

$168 SF/Yr

The suite pairs private work areas with reception space, a kitchenette, storage, and a private restroom.

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Modern Office Space for Lease
Modern Office Space for Lease

11400 Veterans Memorial Pkwy, Lake St Louis, MO 63367

Contact for pricing
4–6 people  1,000 sqft

Flexible office suites with spacious floor plans, customizable layouts, and ample parking for convenient day-to-day operations.

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Renovated Medical Office Suites
Full service
Renovated Medical Office Suites

St Peters, MO 63376

Contact for pricing
2,724 sqft

Newly renovated second-floor suites ranging from small to large medical or professional office configurations.

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Office Units with Covered Walkway
Office Units with Covered Walkway

C-1405 Jungermann Rd, Saint Peters, MO 63376

Class A
$2,838/Mo
7–11 people  1,798 sqft
Highway access

Three finished office suites in a suburban business park with separate support areas and convenient regional highway access.

60 parking spaces  Covered walk way
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Two-Story Medical Office Building
Full service
Two-Story Medical Office Building

St Peters, MO 63376

Contact for pricing
75–125 people  1 space  18,763 sqft

Divisible office space includes signage, elevator access, and renovated suite and common-area interiors.

93 parking spaces
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Medical Office Suite with Monument Signage
Medical Office Suite with Monument Signage

O Fallon, MO 63368

Contact for pricing
2,184 sqft

Medical office suite in a newer building with monument signage and building signage near local amenities.

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Office Suites with Covered Walkway
Office Suites with Covered Walkway

1405 Jungermann Road #C, St Peters, MO 63376

Class A
$2,838/Mo
7–11 people  1,798 sqft  Built 2003
Highway access

Two connected suites offer finished interiors, individual restrooms, and utility rooms.

60 parking spaces  Covered walk way  Marque signage rights
View details
Fully Built-Out Medical Office Suite
Triple net (NNN)
Fully Built-Out Medical Office Suite

O Fallon, MO 63366

Contact for pricing
1,707 sqft

Fully built-out 1,707 SF medical suite available in a multi-tenant retail building with monument and building signage.

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Office Units
Office Units

O Fallon, MO 63368

Contact for pricing
42–70 people  1 space  10,600 sqft

Commercial office space suitable for professional users in a substantial multi-suite property.

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Class A Office Building
Class A Office Building

O Fallon, MO 63368

Class A
Contact for pricing
Built 2009
Highway access

Corporate office setting with on-site fitness, café, parking, and prominent signage opportunities.

5.0/1,000 SF parking  Fitness center  Full-service cafe  Atrium lobby
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Three-Office Suite
Full service
Three-Office Suite

O Fallon, MO 63366

Contact for pricing
2–3 people  1 space  529 sqft  Floor 1
3 private offices  Highway access

First-floor office space offers three entrances and access to a large parking lot.

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Medical/Professional Office Suite For Rent
Full service
Medical/Professional Office Suite For Rent

114 Piper Hill Dr, St Peters, MO

Contact for pricing
7,180 sqft  1 acre

Medical/professional office suite available for lease with monument signage.

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St Peters Office Space Available
Triple net (NNN)
St Peters Office Space Available

4600 Executive Center Pkwy, St Peters, MO

Contact for pricing
19–32 people  1 space  4,826 sqft  2.17 acres

Office space available in St Peters, move-in November 2025.

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O'Fallon Office Space Available
O'Fallon Office Space Available

O Fallon, MO

Contact for pricing
3–6 people  1 space  966 sqft  1.33 acres

Office space available for lease in O'Fallon, Missouri.

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Lake St Louis, MO Office Spaces Lease Rates & Market Statistics

Explore 33 Office Spaces for lease in Lake St Louis, MO on Realmo, a commercial real estate exchange covering the Lake St Louis area. The current inventory totals 133,092 square feet of properties — an average of ~4,050 SF per listing.

Office Spaces lease rates in Lake St Louis range from $14 SF/Yr at the entry level to $168 SF/Yr at the top of the market, averaging $69.59 SF/Yr. That's a 12x spread between entry-level and premium space, making side-by-side comparison of asking rents and lease terms essential. At $69.59 SF/Yr, the local average runs 197% above Missouri's state average of $23.40 SF/Yr.

Lake St Louis accounts for 40% of the 83 office spaces currently available across St. Charles County, where nearby markets include Saint Charles and St Peters. By space type, the market includes 26 office units, 7 medical office space listings and 4 office buildings — office buildings typically offer the lowest entry point, while office units command the highest rates.

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