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    Lady Lake, FL Office Properties & Spaces for Lease

    8 results
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    High Visibility Lady Lake Office
    $6,000 /Mo
    2,570 SF

    High Visibility Lady Lake Office

    126 N US HIGHWAY 27, Lady Lake, FL 32159

    2,500 sqft commercial building with high traffic exposure.

    • High visibility location at the intersection of US Hwy 27 and SR 466.
    • Exceptional exposure to approximately 30,000 vehicles per day on US Hwy 27 and 16,600 vehicles per day on Hwy 466.
    • 2,500 sqft stand‑alone commercial building.
    • Flexible layout suitable for various professional uses.
    • Includes 16 cubicle workstations, 2 private offices, 3 conference rooms, 2 private bathrooms, and a staff kitchenette.
    Updated: Feb 23
    View details
    Medical Office in The Villages
    $30 SF/Yr
    4,932 SF

    Medical Office in The Villages

    1400 N US Highway 441, Lady Lake, FL

    Turnkey medical office building on UF Health Spanish Plaines campus.

    • Prime location on UF Health Spanish Plaines Hospital campus in The Villages.
    • Turnkey single‑user medical office building.
    • High visibility on US HWY 441 (41,000 AADT).
    • Abundant parking (5/1,000 ratio) with cross‑access to UF Health hospital.
    • Well‑designed layout: Featuring 10 exam rooms, 3 offices, lab, conference room, and a large waiting area.
    Updated: Nov 10, 2025
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    Medical Office in The Villages
    $30 SF/Yr
    4,932 SF

    Medical Office in The Villages

    Turnkey medical office building on UF Health Spanish Plaines campus.

    1400 U.S. 441, Lady Lake, FL 32159
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    Class A Medical Office Space
    $21 SF/Yr
    2,736 SF

    Class A Medical Office Space

    Medical office space for rent with outpatient surgery center.

    201 W Guava St, Lady Lake, FL
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    Stand-Alone Commercial Building For Lease
    Contact for pricing
    2,500 SF

    Stand-Alone Commercial Building For Lease

    2,500 SF stand-alone commercial building with high visibility.

    126 US-441, Lady Lake, FL 32159
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    Medical/Professional Office in The Villages
    Contact for pricing
    1,944 SF

    Medical/Professional Office in The Villages

    Upscale medical/professional office space for lease in Lady Lake.

    929 US-441, Lady Lake, FL 32159
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    Medical Office in Summit Park
    Contact for pricing

    Medical Office in Summit Park

    Finished medical office space near UF Health Hospital and The Villages.

    741 Co Rd 466, Lady Lake, FL 32159
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    High-Visibility Retail/Office Space Available
    Contact for pricing
    4,000 SF

    High-Visibility Retail/Office Space Available

    Newly completed building with high traffic exposure in The Villages.

    13922 US-441, Lady Lake, FL 32159
    View details
    Based on your search, we've compiled 25 Potential Opportunities for your consideration. Besides 8 Active listings in Lady Lake, FL, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 9 Properties for Sales.

    Explore Office properties & Spaces for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Medical/Office Building in The Villages
    Contact for pricing

    Medical/Office Building in The Villages

    Standalone medical/office building in a high-traffic location.

    1503 Buenos Aires Boulevard #150, The Villages, FL 32159
    View details
    Medical/Office Building in The Villages
    Contact for pricing
    3,264 SF

    Medical/Office Building in The Villages

    Standalone medical/office building in The Villages, available February 1, 2026.

    1503 Buenos Aires Boulevard #150, The Villages, FL 32159
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    Office or Medical Space Available
    $21 SF/Yr
    3,000 SF

    Office or Medical Space Available

    Office or medical space for rent near The Villages.

    17820 SE 109th Ave, Summerfield, FL
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    Highway 441 Frontage Building
    Contact for pricing
    3,000 SF

    Highway 441 Frontage Building

    New 3,000 Sq Ft Office/Medical/Retail Space for rent.

    17154 SE 109th Terrace Rd, Summerfield, FL 34491
    View details

    Explore Similar Spaces for Sale in Lady Lake, FL

    Consider Similar Space for Sale. We found 9 Spaces matching your search parameters.

    Luxurious Medical Suite in Lady Lake
    $1,300,000
    0.09 Acres

    Luxurious Medical Suite in Lady Lake

    Move-in-ready medical suite with high-end finishes and flexible layout.

    809 County Road 466 unit: 202C, Lady Lake, FL 32159
    View details
    Lady Lake Professional Plaza Office
    $640,000
    2,328 SF

    Lady Lake Professional Plaza Office

    Office space in Lady Lake Professional Plaza available for sale.

    918 ROLLING ACRES, Lady Lake, FL 32159
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    Lady Lake Office Near US-441
    $260,000
    928 SF

    Lady Lake Office Near US-441

    Office space in Lady Lake near The Villages Community.

    918 ROLLING ACRES ROAD, Lady Lake, FL 32159
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    Medical/Professional Space in Lady Lake
    $619,000
    1,920 SF

    Medical/Professional Space in Lady Lake

    Medical-ready/professional space with excellent synergy in a desirable location.

    749 COUNTY ROAD 466, Lady Lake, FL 32159
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    Medical Office in Summit Park
    $700,000
    1,920 SF

    Medical Office in Summit Park

    1,920 SF medical office space with new three-year lease.

    737 COUNTY ROAD 466, Lady Lake, FL 32159
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    Medical/Professional Office in Lady Lake
    Contact for pricing
    10,266 SF

    Medical/Professional Office in Lady Lake

    Two-building medical/professional office space for sale in Lady Lake.

    301 Skyline Dr, Lady Lake, FL 32159
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    Medical Office Investment Opportunity
    $700,000
    1,920 SF

    Medical Office Investment Opportunity

    Leased medical office in growing area near The Villages.

    737 Hwy 466, Lady Lake, FL 32159
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    Medical Office in Lady Lake
    $600,000
    1,920 SF

    Medical Office in Lady Lake

    Fully leased medical office space in a prime location.

    781 Co Rd 466, Lady Lake, FL 32159
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    Medical Office Ready For Sale
    $619,000
    1,920 SF

    Medical Office Ready For Sale

    Medical/Professional office space for sale in Lady Lake, Florida.

    749 Co Rd 466, Lady Lake, FL 32159
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Lady Lake Multi-Use Development Land
    Contact for pricing

    Lady Lake Multi-Use Development Land

    44-acre multi-use development site near The Villages.

    Teague Trl, Lady Lake, FL
    View details
    Lady Lake Development Opportunity
    Contact for pricing

    Lady Lake Development Opportunity

    44-acre multi-use development site in Lady Lake, Florida.

    406 Griffin Ave, Lady Lake, FL
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    Retail Space on 3 Acres
    Contact for pricing

    Retail Space on 3 Acres

    Single tenant retail space available for rent on 3 acres.

    431 US-441, Lady Lake, FL 32159
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    Land on US Hwy 441
    Contact for pricing

    Land on US Hwy 441

    Land with high traffic count near future residential development.

    Shadow Hill Dr, Fruitland Park, FL
    View details

    Lady Lake, FL Office properties & Spaces Leasing Opportunities Market Analysis

    Explore Office properties & Spaces leasing options in Lady Lake, FL with 8 listings featured on our commercial real estate exchange. The current inventory includes 397,441,440 square feet of properties with an estimated lease value of $79 SF/Yr.

    Estimated lease rates for Office properties & Spaces in Lady Lake, FL begin at $21 SF/Yr, with an average of $26 SF/Yr and extend to $30 SF/Yr.
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