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    Downtown San Francisco, CA Office Spaces for Lease

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    Two-Story Commercial Building
    Updated: Aug 1, 2025
    Two-Story Commercial Building

    729 Bush Street, San Francisco, CA 94108

    $8,000/Mo
    5,072 sqft
    Two‑story commercial building plus basement, built in 1911
    Approx. 5,072 sq ft on a 3,781 sq ft lot
    RC‑4 zoning supports a wide range of commercial uses
    Includes basement and 3 bathrooms (Bathroom 1, Bathroom 2, Bathroom 3)
    Located in San Francisco’s Lower Nob Hill, blocks from Union Square and the Financial District
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    Medical Office Suite on Third Floor
    Updated: Jun 16
    Medical Office Suite on Third Floor

    950 Stockton Street # 307, San Francisco, CA 94108

    $4,200/Mo
    1,142 sqft
    Approximately 1,142 RSF available on the 3rd floor at 950 Stockton Street in San Francisco’s Chinatown
    Functional layout with multiple private offices/exam rooms
    Built‑in sink and cabinetry areas in the suite
    Includes access to a private shower/restroom
    Elevator‑served building with convenient access to public transportation, the Financial District, North Beach, and downtown San Francisco
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    3rd-Floor Medical Office Suite
    3rd-Floor Medical Office Suite

    307-950 Stockton St, San Francisco, CA 94108

    $4,200/Mo
    1,142 sqft

    Elevator-served 3rd-floor suite with private offices, exam rooms, and built-in sink areas plus a private shower/restroom.

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    Move-In Ready Office Suite
    Move-In Ready Office Suite

    375-950 Stockton St, San Francisco, CA 94108

    $3,800/Mo
    690 sqft

    Bright, updated suite with corner windows and a reception plus two private offices for professional and service uses.

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    Corner Office Suite with Reception
    Corner Office Suite with Reception

    950 Stockton Street # 375, San Francisco, CA 94108

    $3,800/Mo
    690 sqft

    Move-in ready office suite with reception area, two private offices, and corner windows in an elevator-served building.

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    Side-Core Office Suites
    Side-Core Office Suites

    755 Sansome St, San Francisco, CA 94111

    $45 SF/Yr
    4,378 sqft

    Lease office space with exposed ceiling features across multiple floors in a highly improved 2017–2018 building.

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    Office Suite on Stockton Street
    Office Suite on Stockton Street

    950 Stockton Street 307, San Francisco, CA 94108

    $4,200/Mo
    1,142 sqft

    Office suite available for rent at 950 Stockton Street, Suite 307.

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    Class A Office Space
    Class A Office Space

    71 Stevenson St, San Francisco, CA 94105

    $57 SF/Yr
    1,993 sqft

    Prime office space in San Francisco's vibrant South Financial district.

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    Penthouse Office with Outdoor Decks
    Penthouse Office with Outdoor Decks

    45 Belden Pl, San Francisco, CA 94108

    $45 SF/Yr
    2,035 sqft

    Top floor office with private offices and outdoor space.

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    Office Space with Treatment Rooms
    Office Space with Treatment Rooms

    150 Lombard St, San Francisco, CA 94111

    $67 SF/Yr
    1,200 sqft

    Office space featuring treatment rooms and shared amenities for rent.

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    CA, San Francisco - 388 Market Street
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    Office Building with Updated Lobby
    Office Building with Updated Lobby

    300 Mission St, San Francisco, CA 94105

    Contact for pricing
    14,485 sqft

    Brand new lobby renovation and ground-floor remodel in a multi-story office building with secured subterranean parking and 24/7 security.

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    High-Rise Office Space with Views
    High-Rise Office Space with Views

    600 California St, San Francisco, CA 94108

    Contact for pricing
    2,827 sqft

    Highly efficient side-core office space with natural light, fitness amenities, and on-site parking.

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    CA, San Francisco - 101 Montgomery
    CA, San Francisco - 101 Montgomery

    101 Montgomery St, Unit 900, San Francisco, CA 94111

    15 available spaces from 11 to 1,676 sqft
    $129-$30,619/Mo

    Find fully flexible work and meeting space in CA, San Francisco - 101 Montgomery. Book a tour & get info

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    Historic Office Building with Parking
    Historic Office Building with Parking

    85 2nd St, San Francisco, CA 94105

    Contact for pricing
    8,273 sqft

    Historic office building offering open, creative space with large efficient floorplates and on-site parking.

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    Office Suite with Roof Deck
    Office Suite with Roof Deck

    369 Pine St, San Francisco, CA 94104

    $36 SF/Yr
    1,071 sqft

    Suite includes reception, five private offices, a kitchen, and a roof deck with stair-only access.

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    Spaces Levi's Plaza
    Spaces Levi's Plaza

    1160 Battery St, San Francisco, CA 94111

    15 available spaces from 11 to 1,723 sqft
    $129-$17,496/Mo

    Find fully flexible work and meeting space in Spaces Levi's Plaza. Book a tour & get info

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    Lower-Level Office Space Available
    Lower-Level Office Space Available

    30 Hotaling Pl, San Francisco, CA 94111

    $42 SF/Yr
    6,000 sqft

    6,000 RSF office space with rooftop deck access.

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    California Street
    California Street

    50 California St, Unit 1500, San Francisco, CA 94111

    16 available spaces from 11 to 1,702 sqft
    $129-$33,696/Mo

    Flexible workspace in California Street. Book a tour & get info

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    Sublease Office with Column-Free Floors
    Sublease Office with Column-Free Floors

    181 Fremont St, San Francisco, CA 94105

    Contact for pricing
    13,461 sqft

    Interconnecting stair and column-free floorplates with floor-to-ceiling windows, furnished, and commercial kitchen/cafeteria.

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    Sublease Office Space
    Sublease Office Space

    425 Bush St, San Francisco, CA 94108

    Contact for pricing
    6,463 sqft

    Available office space offered for sublease at 425 Bush St in San Francisco.

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    Creative Plug-and-Play Office Sublease
    Creative Plug-and-Play Office Sublease

    315 Montgomery St, San Francisco, CA 94104

    Contact for pricing
    14,027 sqft

    Creative plug-and-play sublease available with 14,027 to 43,339 RSF at 315 Montgomery St.

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    Office Condo Suite
    Office Condo Suite

    950 Stockton, San Francisco, CA 94108

    $4,000/Mo

    Office condo available for immediate use in San Francisco’s financial district, across from a subway station.

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    Prime Jackson Square Office Space
    Prime Jackson Square Office Space

    414 Jackson Street, San Francisco, CA 94111

    $39 SF/Yr
    22,716 sqft

    Classic brick and timber building in Jackson Square, San Francisco.

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    Downtown San Francisco, CA Office Spaces Market Trends and Statistics

    Explore Office Spaces leasing options in Downtown San Francisco, CA with 153 listings featured on our commercial real estate exchange. The current inventory includes 1,718,755 square feet of properties with an estimated lease value of $122,606.

    Estimated lease rates for Office Spaces in Downtown San Francisco, CA begin at $1.14 SF/Yr, with an average of $834.06 /Mo and extend to $91,110.
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    Most Searched ZIP Codes in San Francisco, CA

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