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    Downtown San Francisco, CA Commercial Real Estate for Lease

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    South San Francisco, CA Bishop, CA Lincoln, CA
    169 results
    CA, San Francisco - 101 Montgomery
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    San Francisco Commercial Space Available
    $8,000/Mo
    3,795 SF

    San Francisco Commercial Space Available

    729 Bush Street, San Francisco, CA 94108

    Two-story commercial building in Lower Nob Hill for rent.

    • Prime location in Lower Nob Hill, San Francisco, near Union Square and the Financial District
    • Versatile RC‑4 zoning allows for a wide range of commercial uses
    • Rare large 3,781 sq ft lot for the area
    • Excellent transportation access via BART, cable cars, and MUNI
    • Redevelopment potential, including vertical expansion and modern medical build‑outs
    Updated: Aug 1, 2025
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    Spaces Levi's Plaza
    $129-$5,116/Mo

    Spaces Levi's Plaza

    1160 Battery St, San Francisco, CA 94111

    Find fully flexible work and meeting space in Spaces Levi's Plaza

    • Make a home for yourself and your team in a private office, fully serviced and flexible, with everything included
    • Grow in a modern workplace with the added advantage of a benefits program offering exclusive discounts and bespoke procurement support
    • Find your own private desk in a beautifully designed shared workspace with 24/7 access, a personal locker, and an inviting reception team
    • Virtual offices allow you to establish a presence at any Spaces location worldwide with mail handling, a virtual call assistant, and on‑demand access
    • Spaces' meeting rooms have everything you need from audiovisual equipment, whiteboards, and Wi‑Fi to food and beverage services
    Updated: Feb 19
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    California Street
    $129-$6,436/Mo

    California Street

    Discover many ways to work your way in California Street

    50 California St, Unit 1500, San Francisco, CA 94111
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    San Francisco Office Space Available
    $45 SF/Yr
    2,035 SF

    San Francisco Office Space Available

    Office space for lease in San Francisco with exposed brick.

    45 Belden Pl, San Francisco, CA 94104
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    Penthouse Office with Outdoor Decks
    $45 SF/Yr
    2,035 SF

    Penthouse Office with Outdoor Decks

    Top floor office with private offices and outdoor space.

    45 Belden Pl, San Francisco, CA 94108
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    Office Space with Treatment Rooms
    $67 SF/Yr
    1,200 SF

    Office Space with Treatment Rooms

    Office space featuring treatment rooms and shared amenities for rent.

    150 Lombard St, San Francisco, CA 94111
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    CA, San Francisco - 580 California
    $129-$5,265/Mo

    CA, San Francisco - 580 California

    Discover many ways to work your way in CA, San Francisco - 580 California

    580 Floors, San Francisco, CA 94104
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    505 Montgomery
    $129-$6,196/Mo

    505 Montgomery

    All-inclusive access to workspace, virtual office and meeting rooms in 505 Montgomery

    505 Floors, San Francisco, CA 94111
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    Class A Retail Space Available
    Contact for pricing
    700 SF

    Class A Retail Space Available

    Prime retail space in a growing San Francisco neighborhood.

    215 Fremont St, San Francisco, CA 94105
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    CA, San Francisco - 71 Stevenson St
    Contact for pricing

    CA, San Francisco - 71 Stevenson St

    Workspaces, services and support to help you work better in CA, Campbell - Orchards City Dr

    71 Stevenson St, San Francisco, CA 94105
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    Retail Space in Transbay Area
    Contact for pricing

    Retail Space in Transbay Area

    Retail space available in a rapidly growing neighborhood.

    420-488 Folsom St, San Francisco, CA 94105
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    Ritz-Carlton Retail & Spa Space
    Contact for pricing
    356 SF

    Ritz-Carlton Retail & Spa Space

    Luxury retail and former spa space at the Ritz-Carlton Hotel.

    600 Stockton St, San Francisco, CA 94108
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    San Francisco Retail Space Available
    Contact for pricing
    3,975 SF

    San Francisco Retail Space Available

    Retail space for lease in Class A office building.

    100 California St, San Francisco, CA 94111
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    Prime Jackson Square Office Space
    $39 SF/Yr
    22,716 SF

    Prime Jackson Square Office Space

    Classic brick and timber building in Jackson Square, San Francisco.

    414 Jackson Street, San Francisco, CA 94111
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    Class A Office Space Available
    Contact for pricing
    3,721 SF

    Class A Office Space Available

    Prominent 34-story Class A office building in the South Financial District.

    555 Mission St, San Francisco, CA 94105
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    San Francisco Retail/Office Space
    $6,000/Mo
    1,500 SF

    San Francisco Retail/Office Space

    Retail or office space available for rent in San Francisco.

    643 Mission Street, San Francisco, CA 94105
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    Retail Space Near Transbay Terminal
    Contact for pricing
    2,100 SF

    Retail Space Near Transbay Terminal

    Remodeled retail space with high ceilings and ample sunlight.

    301 Howard St, San Francisco, CA 94105
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    Panoramic City and Bay Views
    Contact for pricing
    967 SF

    Panoramic City and Bay Views

    Office tower with customizable suites and direct mass transit access.

    1 Post St, San Francisco, CA 94104
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    Four Embarcadero Center Office Sublease
    Contact for pricing
    21,858 SF

    Four Embarcadero Center Office Sublease

    Office space available for sublease in San Francisco.

    4 Embarcadero Ctr, San Francisco, CA 94111
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    Class A Office Space
    Contact for pricing
    1,993 SF

    Class A Office Space

    Prime office space in San Francisco's vibrant South Financial district.

    71 Stevenson St, San Francisco, CA 94105
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    Jackson Square Office Space Available
    $85 SF/Yr
    5,400 SF

    Jackson Square Office Space Available

    Sublease opportunity in Jackson Square with creative finishes.

    402 Jackson St, San Francisco, CA 94111
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    Office Space in Central Plaza
    Contact for pricing
    25,250 SF

    Office Space in Central Plaza

    Office space available for sublease in San Francisco.

    455 Market St, San Francisco, CA 94105
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    San Francisco Office Space Available
    Contact for pricing
    4,112 SF

    San Francisco Office Space Available

    Office space for lease in San Francisco with flexible floorplates.

    115 Sansome St, San Francisco, CA 94104
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    Downtown San Francisco, CA Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in Downtown San Francisco, CA with 169 listings featured on our commercial real estate exchange. The current inventory includes 3,116,282 square feet of properties with an estimated lease value of $93,797.

    Estimated lease rates for Commercial real estate in Downtown San Francisco, CA begin at $0.74 SF/Yr, with an average of $276 SF/Yr and extend to $30,000.
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    Most Searched ZIP Codes in San Francisco, CA

    • 94111
    • 94105
    • 94104
    • 94108

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