Sanford, FL Office buildings for Rent & Lease

Updated: Apr 29, 2025

Office Building with Private Parking

500 E AIRPORT Boulevard, Sanford, FL 32773

$7,495/Mo

5,124 sqft 1.09 AC lot

5,124 SF office building on 1.09 acres
Seven oversized rooms with potential for additional partitioning
More than 350 feet of frontage along E Airport Boulevard
Private parking lot with 42 spaces plus a two‑car carport
Two bathrooms, kitchenette, and laundry room with multiple sinks and hookups

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Updated: May 25

Spacious Sanford Commercial Building For Rent

500 E Airport Boulevard, Sanford, FL 32773

$7,495/Mo

5,124 sqft

High‑visibility location: Over 350 ft of frontage on busy E Airport Blvd.
Large commercial space: 5124 sq ft GC2 commercial building.
Ample parking: Private parking lot with 42 spaces.
Flexible layout: Currently divided into 7 oversized rooms, easily customizable.
Functional amenities: Includes 2 bathrooms, kitchenette, laundry room, and 2‑car carport.

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Renovated Office Building in Sanford

1270 Upsala Road, Sanford, FL 32771

$17.50 SF/Yr

23,700 sqft

Recently renovated office building with modern amenities and prime location.

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Freestanding Commercial Building with Drive-Thru

1381 Rinehart Rd, Sanford, FL 32771

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5,301 sqft 1.21 AC lot

Freestanding building with drive-thru lanes and ample on-site parking; visibility from Rinehart Road.

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Versatile Commercial Office Building For Rent

502 E AIRPORT Blvd, Sanford, FL 32773

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2,641 sqft 0.24 AC lot

2641 sq ft office building with reception and offices.

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Freestanding Office Building

1701 E Airport Blvd, Sanford, FL 32773

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2,654 sqft

Freestanding office building with 8 built-out offices and 52 on-site parking spaces.

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Based on your search, we've compiled 15 Potential Opportunities for your consideration. Besides 6 Active listings in Sanford, FL, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 5 Properties for Sales.

Office buildings for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Lake Mary Office Space Available

3300 West Lake Mary Blvd, Lake Mary, FL 32746

$18.75 SF/Yr

28,183 sqft

28,183± SF office space in Lake Mary, excellent location.

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Class A Office Building

100 Colonial Center Parkway, Lake Mary, FL 32746

$34.50 SF/Yr

Five-story office building with on-site amenities in mixed-use development.

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Modern Office Building

200 Colonial Center Pkwy, Lake Mary, FL 32746

Contact for pricing

17,608 sqft

Energy Star-rated office building offers large floorplates, ample parking, and dual-feed electrical service.

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Lake Mary Office Space Available

400 Colonial Center Pkwy, Lake Mary, FL 32746

Contact for pricing

Office building in Lake Mary, LEED Silver certified.

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Similar Spaces for Sale in Sanford, FL

Consider Similar Space for Sale. We found 5 Spaces matching your search parameters.

Freestanding Medical Office

2105 S PARK Avenue, Sanford, FL 32771

$549,000

1,550 sqft 0.28 AC lot

Standalone medical office with private parking, a fenced yard, and PD zoning along Park Avenue.

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Sanford Commercial Building For Sale

333 GORDON STREET, Sanford, FL 32771

$949,000

3,360 sqft

Free-standing commercial building near Downtown Sanford with easy highway access.

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Medical Office Building

1400 S Park Ave, Sanford, FL 32771

Contact for pricing

2,150 sqft

Healthcare-oriented property in Sanford’s Historic District with connectivity to US-17-92, SR-46, and Interstate 4.

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Standalone Medical Office Building

2105 S PARK, Sanford, FL 32771

$549,000

Former pediatric practice with private parking and a fenced yard.

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Waterfront Land with Office Building

4950 46A Road, Sanford, FL 32771

$1,950,000

1,000 sqft 24.00 AC lot

Cleared waterfront tract with an existing office building and AG zoning.

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Sanford, FL Office buildings Lease Rates & Market Statistics

Explore 6 Office buildings for lease in Sanford, FL on Realmo, a commercial real estate exchange covering the Sanford area. The current inventory totals 44,544 square feet of properties.

Asking lease rates for Office buildings in Sanford start at $17.50 SF/Yr, average $17.53 SF/Yr, and reach $17.55 SF/Yr at the top of the market. Pricing across the market is relatively uniform, which simplifies like-for-like comparison between listings. The local average of $17.53 SF/Yr is 35% below the Florida state average of $26.85 SF/Yr.

Sanford accounts for 8% of the 71 office buildings currently available across Seminole County, where nearby markets include Lake Mary and Altamonte Springs. Office buildings make up 13% of the 48 Office Spaces currently for lease in Sanford, with asking rates averaging $17.53 SF/Yr — 50% below the citywide Office Spaces average of $35.02 SF/Yr. Also worth a look for tenants weighing alternatives: Office Units (41 listings) and Medical Office Space (5 listings) elsewhere in the Sanford market.