La Mesa, CA Office buildings for Rent & Lease

Updated: Jul 17

Professional Office Building

5565 Grossmont Center Dr., La Mesa, CA 91942

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3,898 sqft

Office building for lease in La Mesa
Approximately 3,898 sq. ft. of commercial workspace
Built in 2026

Based on your search, we've compiled 10 Potential Opportunities for your consideration. Besides 1 Active listings in La Mesa, CA, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 5 Properties for Sales.

Office buildings for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Office Building for Lease

5555 Reservoir Dr., San Diego, CA 92120

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10,403 sqft

Office building available for rent at 5555 Reservoir Dr. in San Diego.

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Convenient Office Space Near I-15

3655 Ruffin Rd., San Diego, CA 92123

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Office space with easy access to I-15 and amenities.

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Dynamic San Diego Office Campus

9635 Granite Ridge Dr, San Diego, CA 92123

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14,939 sqft

First-class office campus with robust amenities and freeway access.

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San Diego Office Campus

3530, 3550, & 3570 Camino del Rio N, San Diego, CA 92108

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4.20 AC lot

Three-building office campus in central San Diego with modern renovations.

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Similar Spaces for Sale in La Mesa, CA

Consider Similar Space for Sale. We found 5 Spaces matching your search parameters.

Single-Tenant Office Building with Billboard

8167-69 Center Street, La Mesa, CA 91942

$1,700,000

5,236 sqft

The property combines full occupancy with rooftop billboard space and M Zone industrial zoning near the (8) Freeway.

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Landmark Office Building in La Mesa

7578 El Cajon Blvd, La Mesa, CA 91942

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22,500 sqft 0.84 AC lot

Three-story office building on a highly visible corner lot.

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Leased Office Building Opportunity

8911 La Mesa Boulevard, La Mesa, CA 91942

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13,978 sqft

Well-located office building offered as a leased investment or owner/user opportunity between major freeways.

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Atrium-Style Office Building

7484 University Ave, La Mesa, CA 91942

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Office suites feature private restrooms and a circular layout centered on an atrium with floor-to-ceiling glass.

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Freestanding Office Building

4495 Dale Avenue, La Mesa, CA 91941

$1,450,000

Two-level office property combines an available suite with leased corporate office space.

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La Mesa, CA Office buildings Lease Rates & Market Statistics

Explore 1 Office buildings listing for lease in La Mesa, CA on Realmo, a commercial real estate exchange covering the La Mesa area. The current inventory totals 3,898 square feet of properties.

La Mesa accounts for 1% of the 173 office buildings currently available across San Diego County, where nearby markets include San Diego and Carlsbad. Office buildings are one of the more limited space types in La Mesa, with just 1 listing currently available — a scarcity worth factoring into lease negotiations. Tenants comparing options may also consider Office Units (9 listings) and Medical Office Space (3 listings) elsewhere in the La Mesa market.

La Mesa, CA Office Buildings for Lease

5565 Grossmont Center Dr., La Mesa, CA 91942