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    Greenwood County, SC Mixed-use Properties for Sale

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    Versatile Commercial Flex Property
    $799,900
    6,000 SF

    Versatile Commercial Flex Property

    463 Calhoun Ave, Greenwood, SC 29646

    6,000 sq ft commercial flex property in Greenwood, SC.

    • 6,000 sq ft commercial flex property in a thriving commercial district.
    • Potential to reconfigure into 4 units for increased rental income.
    • Currently divided into 3 units (3,000 sq ft, two 1,500 sq ft units) offering immediate income potential.
    • Recently resurfaced parking lot providing ample parking.
    • Ideal for a mix of office, retail, or light industrial use.
    Updated: Mar 17
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    Historic Uptown Greenwood Commercial Property
    $749,000
    4,684 SF

    Historic Uptown Greenwood Commercial Property

    206 Main St, Greenwood, SC 29649

    Versatile commercial space in a vibrant historic district with unique features.

    • Prime Location: Situated in the heart of Uptown Greenwood with high visibility and foot traffic.
    • Versatile Space: Just under 5,000 sqft with a flexible layout suitable for retail, office, or mixed‑use purposes. Includes seven private office suites, a shared kitchenette, and a large basement.
    • Historic Charm: Features original hardwood floors, ghost murals (including a vintage Coca‑Cola mural), and architectural details reflecting its 1917 origins.
    • Ample Parking: Benefits from an expansive city‑owned front lot providing abundant parking.
    • Turnkey Opportunity: Includes all remaining furnishings upstairs, making it ready for a new business/owner.
    Updated: Sep 9, 2025
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    Versatile Commercial Building, Greenwood SC
    $159,000
    1,722 SF

    Versatile Commercial Building, Greenwood SC

    Adaptable commercial building with high visibility and flexible build-out options.

    1601 E Cambridge Ave, Greenwood, SC 29646
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    Iconic Mixed-Use Property, Greenwood SC
    $479,000
    4,753 SF

    Iconic Mixed-Use Property, Greenwood SC

    Mixed-use property in vibrant Uptown Greenwood, ideal for live/work.

    204 Main St, Greenwood, SC 29649
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    Retail Building on Crosscreek Connector
    Contact for pricing
    4,320 SF

    Retail Building on Crosscreek Connector

    Retail building on one acre with expansion potential.

    167 Crosscreek Connector, Greenwood, SC 29649
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    Based on your search, we've compiled 8 Potential Opportunities for your consideration. Besides 5 Active listings in Greenwood County, SC, we suggest exploring several alternatives: plus 3 Land Listings that present a potential for development.

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Greenwood Commercial Corner Lot Opportunity
    $174,000
    0.54 Acres

    Greenwood Commercial Corner Lot Opportunity

    Prime commercial corner lot in Greenwood's active corridor.

    441/433 Calhoun Ave, Greenwood, SC 29649
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    Lake Greenwood Development Opportunity
    $2,000,000
    5.00 Acres

    Lake Greenwood Development Opportunity

    5-acre waterfront property zoned for residential or mixed-use development.

    7125 Ninety Six Hwy, Ninety Six, SC 29666
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    Lake Greenwood Waterfront Development Opportunity
    $2,000,000
    5.00 Acres

    Lake Greenwood Waterfront Development Opportunity

    5-acre waterfront property with development potential on Lake Greenwood.

    7125 Ninety Six Hwy, Ninety Six, SC 29666
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    Explore Off-Market Properties in Greenwood County, SC

    Consider similar Off-Market properties in Greenwood County, SC. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    1610 Calhoun Rd

    1610 Calhoun Rd

    STORE/OFFICE (MIXED USE) • 12,000 SF
    Value Estimation
    $645,000
    1610 Calhoun Rd, Greenwood, SC 29649-8907
    View details
    430 Cobb Rd

    430 Cobb Rd

    STORE/OFFICE (MIXED USE) • 4,126 SF
    Value Estimation by Request
    430 Cobb Rd, Greenwood, SC 29649-9002
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    213 Anderson Cir

    213 Anderson Cir

    STORE/OFFICE (MIXED USE) • 2,244 SF
    Value Estimation by Request
    213 Anderson Cir, Greenwood, SC 29649-8908
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    231 Hampton Ave Ste H

    231 Hampton Ave Ste H

    STORE/OFFICE (MIXED USE) • 3,445 SF
    Value Estimation by Request
    231 Hampton Ave Ste H, Greenwood, SC 29646-2299
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    327 Main St, Unit 2

    327 Main St, Unit 2

    STORE/OFFICE (MIXED USE) • 661 SF
    Value Estimation by Request
    327 Main St, Greenwood, SC 29646-1601
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    805 Montague Ave

    805 Montague Ave

    STORE/OFFICE (MIXED USE) • 13,660 SF
    Value Estimation
    $1,645,000
    805 Montague Ave, Greenwood, SC 29649-1471
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    328 Main St

    328 Main St

    STORE/OFFICE (MIXED USE) • 8,149 SF
    Value Estimation
    $540,000
    328 Main St, Greenwood, SC 29646-2797
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    327 Main St

    327 Main St

    STORE/OFFICE (MIXED USE) • 2,523 SF
    Value Estimation by Request
    327 Main St, Greenwood, SC 29646-1601
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    418 Main St

    418 Main St

    STORE/OFFICE (MIXED USE) • 5,190 SF
    Value Estimation by Request
    418 Main St, Greenwood, SC 29646-2756
    View details
    2432-C Hwy 293rd E

    2432-C Hwy 293rd E

    STORE/OFFICE (MIXED USE) • 2,940 SF
    Value Estimation by Request
    2432-C Hwy 293rd E, Greenwood, SC 29649
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    682 Byp 72nd NW

    682 Byp 72nd NW

    STORE/OFFICE (MIXED USE) • 4,186 SF
    Value Estimation by Request
    682 Byp 72nd NW, Greenwood, SC 29649
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    1303 Montague Ave Ext

    1303 Montague Ave Ext

    STORE/OFFICE (MIXED USE) • 5,824 SF
    Value Estimation
    $525,000
    1303 Montague Ave Ext, Greenwood, SC 29649-9028
    View details
    106 Byp 225

    106 Byp 225

    STORE/OFFICE (MIXED USE) • 11,507 SF
    Value Estimation
    $1,170,000
    106 Byp 225, Greenwood, SC 29646-1154
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    529 Byp 72nd NW

    529 Byp 72nd NW

    STORE/OFFICE (MIXED USE) • 8,605 SF
    Value Estimation
    $970,000
    529 Byp 72nd NW, Greenwood, SC 29649-1355
    View details
    314 Main St

    314 Main St

    STORE/OFFICE (MIXED USE) • 10,076 SF
    Value Estimation by Request
    314 Main St, Greenwood, SC 29646-2758
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    327 Main St, Unit 5

    327 Main St, Unit 5

    STORE/OFFICE (MIXED USE) • 651 SF
    Value Estimation by Request
    327 Main St, Greenwood, SC 29646-1601
    View details
    327 Main St, Unit 6

    327 Main St, Unit 6

    STORE/OFFICE (MIXED USE) • 651 SF
    Value Estimation by Request
    327 Main St, Greenwood, SC 29646-1601
    View details
    300 Montague Ave

    300 Montague Ave

    STORE/OFFICE (MIXED USE) • 11,766 SF
    Value Estimation by Request
    300 Montague Ave, Greenwood, SC 29649-1938
    View details
    327 Main St, Unit 3

    327 Main St, Unit 3

    STORE/OFFICE (MIXED USE) • 651 SF
    Value Estimation by Request
    327 Main St, Greenwood, SC 29646-1601
    View details

    Greenwood County, SC Mixed-Use Properties Investment Opportunities Market Analysis

    Explore 37 mixed-use properties for sale in Greenwood County, SC, showcased through 5 active listings on our real estate platform. These investment opportunities span a total of 331,492 square feet of properties for sale, with an estimated market value of $9,122,900.

    Sale prices for multi use buildings in Greenwood County, SC start at $159,000, averaging $912,290, and reaching up to $2,670,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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