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    Saint Charles, MO Mixed-use Properties for Sale

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    Historic Mixed-Use Building in Frenchtown
    $980,000
    8,218 SF

    Historic Mixed-Use Building in Frenchtown

    900 N 2Nd St, Saint Charles, MO 63301

    Mixed-use building with retail and apartments in historic Frenchtown.

    • Prime location in booming Historic Frenchtown, St. Charles, next to the proposed new City Hall.
    • 8,218 sf building with retail space on the main level and five apartments on the upper floors.
    • Three‑story building with historical significance, built in 1880.
    • Second floor features four units (800 sf - 900 sf +/-), with three finished.
    • All units have individual utility services.
    Updated: Aug 21, 2025
    View details
    Based on your search, we've compiled 7 Potential Opportunities for your consideration. Besides 1 Active listings in Saint Charles, MO, we suggest exploring several alternatives: 4 properties in Nearby Cities, plus 2 Land Listings that present a potential for development.

    Explore Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Mixed-Use Property Near Lambert Airport
    Contact for pricing

    Mixed-Use Property Near Lambert Airport

    Mixed-use property with retail and warehouse space, great investment opportunity.

    3444 N Lindbergh Blvd, Saint Ann, MO 63074
    View details
    Mixed-Use Property Near Lambert Airport
    $825,000
    5,500 SF

    Mixed-Use Property Near Lambert Airport

    Mixed-use property with retail and warehouse space, investment opportunity.

    3444 N Lindbergh Blvd, Saint Ann, MO 63074
    View details
    Move-In Ready Mixed-Use Building
    $238,500
    0.10 Acres

    Move-In Ready Mixed-Use Building

    Commercial building in the heart of Old Town Florissant.

    560 N Jefferson St, Florissant, MO 63031
    View details
    Mixed-Use Building with Renovated Spaces
    Contact for pricing
    2,200 SF

    Mixed-Use Building with Renovated Spaces

    Income-producing mixed-use building with renovated office and residential spaces.

    699 Rue Saint Francois St, Florissant, MO
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    St Charles Development Opportunity
    $1,168,100
    9.09 Acres

    St Charles Development Opportunity

    9.09 acres of land in a prime location.

    365 Clarence Dr, Saint Charles, MO 63303
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    St Charles Development Opportunity
    $1,168,100
    9.09 Acres

    St Charles Development Opportunity

    9.09 acres of land in prime location for development.

    365 Clarence Dr, Saint Charles, MO 63303
    View details

    Explore Off-Market Properties in Saint Charles, MO

    Consider similar Off-Market properties in Saint Charles, MO. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    Ehlmann Rd

    Ehlmann Rd

    OFFICE/RESIDENTIAL (MIXED USE) • 25.86 Acres
    Value Estimation by Request
    Ehlmann Rd, Saint Charles, MO 63301
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    Hwy V V

    Hwy V V

    OFFICE/RESIDENTIAL (MIXED USE) • 14.86 Acres
    Value Estimation by Request
    Hwy V V, Saint Charles, MO 63301
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    Huster Rd

    Huster Rd

    OFFICE/RESIDENTIAL (MIXED USE) • 19.29 Acres
    Value Estimation by Request
    Huster Rd, Saint Charles, MO 63301
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    3650 New Town Blvd

    3650 New Town Blvd

    OFFICE/RESIDENTIAL (MIXED USE) • 4.39 Acres
    Value Estimation by Request
    3650 New Town Blvd, Saint Charles, MO 63301-4357
    View details
    3416 Civic Cir

    3416 Civic Cir

    OFFICE/RESIDENTIAL (MIXED USE) • 0.73 Acres
    Value Estimation by Request
    3416 Civic Cir, Saint Charles, MO 63301
    View details
    456 Wright Dr

    456 Wright Dr

    OFFICE/RESIDENTIAL (MIXED USE) • 6,067 SF
    Value Estimation
    $585,000
    456 Wright Dr, Saint Charles, MO 63301-0039
    View details
    1100 2nd St

    1100 2nd St

    OFFICE/RESIDENTIAL (MIXED USE) • 1,512 SF
    Value Estimation by Request
    1100 2nd St, Saint Charles, MO 63301-2102
    View details
    905 2nd St

    905 2nd St

    OFFICE/RESIDENTIAL (MIXED USE) • 2,322 SF
    Value Estimation by Request
    905 2nd St, Saint Charles, MO 63301-2040
    View details
    1534 Boones Lick Rd

    1534 Boones Lick Rd

    OFFICE/RESIDENTIAL (MIXED USE) • 2,704 SF
    Value Estimation by Request
    1534 Boones Lick Rd, Saint Charles, MO 63301-2333
    View details
    1579 Old Hwy 94

    1579 Old Hwy 94

    OFFICE/RESIDENTIAL (MIXED USE) • 2,228 SF
    Value Estimation by Request
    1579 Old Hwy 94, Saint Charles, MO 63303-3737
    View details
    1925 Randolph St

    1925 Randolph St

    OFFICE/RESIDENTIAL (MIXED USE) • 5,586 SF
    Value Estimation
    $640,000
    1925 Randolph St, Saint Charles, MO 63301-0841
    View details
    1700 Randolph St

    1700 Randolph St

    OFFICE/RESIDENTIAL (MIXED USE) • 3,600 SF
    Value Estimation by Request
    1700 Randolph St, Saint Charles, MO 63301-0827
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    3309 Shutten St

    3309 Shutten St

    OFFICE/RESIDENTIAL (MIXED USE) • 2,838 SF
    Value Estimation by Request
    3309 Shutten St, Saint Charles, MO 63301-8035
    View details
    3214 Rue Royale St

    3214 Rue Royale St

    OFFICE/RESIDENTIAL (MIXED USE) • 3,350 SF
    Value Estimation by Request
    3214 Rue Royale St, Saint Charles, MO 63301-8358
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    3308 Rue Royale St

    3308 Rue Royale St

    OFFICE/RESIDENTIAL (MIXED USE) • 8,583 SF
    Value Estimation
    $930,000
    3308 Rue Royale St, Saint Charles, MO 63301-8328
    View details
    1042 David Mdws Ln

    1042 David Mdws Ln

    OFFICE/RESIDENTIAL (MIXED USE) • 7,455 SF
    Value Estimation
    $675,000
    1042 David Mdws Ln, Saint Charles, MO 63304-7622
    View details
    3224 Rue Royale St

    3224 Rue Royale St

    OFFICE/RESIDENTIAL (MIXED USE) • 3,382 SF
    Value Estimation by Request
    3224 Rue Royale St, Saint Charles, MO 63301-8347
    View details
    1065 1st Capitol Dr

    1065 1st Capitol Dr

    OFFICE/RESIDENTIAL (MIXED USE) • 1,710 SF
    Value Estimation by Request
    1065 1st Capitol Dr, Saint Charles, MO 63301-2735
    View details
    547 1st Capitol Dr

    547 1st Capitol Dr

    OFFICE/RESIDENTIAL (MIXED USE) • 2,536 SF
    Value Estimation by Request
    547 1st Capitol Dr, Saint Charles, MO 63301-2763
    View details
    3245 Domain St

    3245 Domain St

    OFFICE/RESIDENTIAL (MIXED USE) • 2,076 SF
    Value Estimation by Request
    3245 Domain St, Saint Charles, MO 63301-8252
    View details
    3309 Domain St

    3309 Domain St

    OFFICE/RESIDENTIAL (MIXED USE) • 2,104 SF
    Value Estimation by Request
    3309 Domain St, Saint Charles, MO 63301-8242
    View details
    24 Faye Ave

    24 Faye Ave

    OFFICE/RESIDENTIAL (MIXED USE) • 3,360 SF
    Value Estimation by Request
    24 Faye Ave, Saint Charles, MO 63301-3103
    View details
    200 Hwy B B

    200 Hwy B B

    OFFICE/RESIDENTIAL (MIXED USE) • 5,068 SF
    Value Estimation by Request
    200 Hwy B B, Saint Charles, MO 63301-6939
    View details

    Saint Charles, MO Mixed-Use Properties Investment Opportunities Market Analysis

    Explore 245 mixed-use properties for sale in Saint Charles, MO on our real estate platform. These investment opportunities span a total of 30,085,580 square feet of properties for sale, with an estimated market value of $30,420,000.

    Sale prices for multi use buildings in Saint Charles, MO start at $55,000, averaging $507,000, and reaching up to $5,240,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Most Searched ZIP Codes in Saint Charles, MO

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    • 63303
    • 63304

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