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Middlesex County, MA Mixed-use Properties for Sale

37 results
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Lowell Mixed-Use Investment Opportunity
$795,000
3,774 SF

Lowell Mixed-Use Investment Opportunity

525 Chelmsford St, Lowell, MA 01851

Mixed-use property with commercial space and residential unit in Lowell.

  • Mixed‑use property featuring commercial space and a large residential unit.
  • Two retail storefronts boast high street visibility and traffic on Chelmsford Street.
  • Off‑street parking for 10+ vehicles plus a carport.
  • Spacious 4‑5 bedroom residential unit with a flexible floor plan.
  • Unfinished 2nd floor offers expansion potential for commercial space.
Updated: Dec 12, 2025
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Mixed-Use Building Near UMASS Lowell
$1,300,000
7,178 SF

Mixed-Use Building Near UMASS Lowell

169-171 Salem St, Lowell, MA 01854

Five-unit mixed-use building with retail space and residential units.

  • 5‑unit mixed‑use building with retail space and residential units.
  • First‑floor retail space includes a kitchen area, 2 walk‑in coolers, 1 walk‑in freezer, and pizza ovens.
  • Two updated 3‑bedroom apartments.
  • All units have separate utilities and washer/dryer hookups.
  • Includes business/Cote's market name, equipment, and inventory.
Updated: Jan 11
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Renovated Mixed-Use Building For Sale
$789,999

Renovated Mixed-Use Building For Sale

Two-story renovated building with office/retail space and luxury apartment.

205 Chelmsford St, Chelmsford, MA 01824
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Marlborough Office & Flex Space
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5,374 SF

Marlborough Office & Flex Space

Office and flex space in a high-visibility Marlborough location.

7-9 Mechanic St, Marlborough, MA 01752
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Somerville Retail Space Opportunity
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1,670 SF

Somerville Retail Space Opportunity

Commercial space in mixed-use building with public and private outdoor spaces.

1060 Broadway St, Somerville, MA 02144
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Lowell Mixed-Use Repositioning Opportunity
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Lowell Mixed-Use Repositioning Opportunity

Two-story building in vibrant area, ideal for medical, office, retail.

Lowell, MA 01854
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Downtown Natick Retail Opportunity
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28,422 SF

Downtown Natick Retail Opportunity

Retail space in a newly developed mixed-use building.

21 Summer St, Natick, MA 01760
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Mixed-Use Development Project Opportunity
$2,999,900

Mixed-Use Development Project Opportunity

Developable mixed-use project with potential for up to 37 units.

176-182 Broadway, Somerville, MA 02145
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Approved Mixed-Use Development Opportunity
$1,099,900

Approved Mixed-Use Development Opportunity

Approved mixed-use development with residential and commercial space.

818 Waverly St, Framingham, MA 01702
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Somerville Retail Space Opportunity
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1,670 SF

Somerville Retail Space Opportunity

Commercial space in mixed-use building with outdoor access.

1060 Broadway, Somerville, MA 02144
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Melrose Mixed-Use Investment Opportunity
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4,448 SF

Melrose Mixed-Use Investment Opportunity

4,448 SF building in Melrose Market with BA-2 zoning.

437-445 Franklin St, Melrose, MA 02176
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Mixed-Use Redevelopment Opportunity
$1,900,000

Mixed-Use Redevelopment Opportunity

Mixed-use building with redevelopment potential in MBTA overlay district.

540 Merrimack St, Lowell, MA 01854
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Downtown Natick Mixed-Use Building
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89,500 SF

Downtown Natick Mixed-Use Building

Street-level retail/restaurant space in a newly developed mixed-use building.

45 East Central St, Natick, MA 01760
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Versatile Arlington Commercial Property
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Versatile Arlington Commercial Property

Mixed-use property with residential, commercial, and industrial components.

52-56 Dudley Street Pl, Arlington, MA 02476
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Mixed-Use Property in Glendale
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3,238 SF

Mixed-Use Property in Glendale

Mixed-use property with commercial, residential, and retail spaces.

826 Broadway, Everett, MA 02149
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Maplewood Square Investment Opportunity
$1,799,000
7,000 SF

Maplewood Square Investment Opportunity

Four-unit commercial building and two-family home in prime location.

697-705 Salem St, Malden, MA 02148
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Mixed-Use Development Opportunity
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Mixed-Use Development Opportunity

Three contiguous lots with mixed-use development potential.

66-68-70 Powder Mill Rd, Maynard, MA 01754
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Mixed-Use Property in Vibrant Location
$1,849,999
9,960 SF

Mixed-Use Property in Vibrant Location

Remodeled mixed-use property with residential units and commercial space.

340 Main St, Everett, MA 02149
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Mixed-Use Property Near Commuter Rail
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Mixed-Use Property Near Commuter Rail

Mixed-use property with auto repair potential near commuter rail.

12 Waverly St, Framingham, MA 01702
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Mixed-Use Restaurant/Residential Building
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Mixed-Use Restaurant/Residential Building

Mixed-use building with restaurant and residential units in Downtown Lowell.

110 Gorham St, Lowell, MA 01852
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Mixed-Use Investment Property in Hudson
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Mixed-Use Investment Property in Hudson

Mixed-use property with retail and apartment units in downtown Hudson.

65 Main St, Hudson, MA 01749
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Mixed-Use Building in Prime Location
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Mixed-Use Building in Prime Location

Mixed-use building with residential and office/retail spaces in Lowell.

42 Branch St, Lowell, MA 01851
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Natick Center Redevelopment Opportunity
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Natick Center Redevelopment Opportunity

Two-family house plus detached commercial/retail building in Natick Center.

49 Summer St, Natick, MA 01760
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Melrose Mixed-Use Investment Opportunity
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Melrose Mixed-Use Investment Opportunity

2,288 SF 3-unit building in thriving Melrose Market.

371-377 Franklin St, Melrose, MA 02176
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Middlesex County, MA Mixed-Use Properties Investment Opportunities Market Analysis

Explore 2976 mixed-use properties for sale in Middlesex County, MA, showcased through 37 active listings on our real estate platform. These investment opportunities span a total of 41,144,626 square feet of properties for sale, with an estimated market value of $818,545,000.

Sale prices for multi use buildings in Middlesex County, MA start at $50,000, averaging $839,533, and reaching up to $14,030,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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