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    San Mateo, CA Medical Office Space for Lease

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    Professional/Medical Office Space Available
    Contact for pricing

    Professional/Medical Office Space Available

    312 N San Mateo Drive, San Mateo, CA 94401

    Professional/Medical office space for lease, near San Francisco International Airport.

    • Prime Location: Just 11 minutes from San Francisco International Airport.
    • High‑Speed Connectivity: Features Fiber Optic Internet with CAT‑6 wiring throughout.
    • Secured Parking: Includes a secured, gated parking lot with 12 spaces.
    • Flexible Zoning: Zoned E2‑1.5, encompassing all E2 and E1 uses.
    • Modern Amenities: Boasts a grand main lobby with a limestone walkway and high ceilings.
    Updated: Jan 27
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    Downtown San Mateo Office Space
    Contact for pricing
    2,500 SF

    Downtown San Mateo Office Space

    101 South San Mateo Drive, San Mateo, CA 94401

    Rare 2500 sqft office space in downtown San Mateo.

    • Rare downtown San Mateo location
    Updated: Nov 22, 2025
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    Medical Office Space Available
    $5 SF/Yr
    1,340 SF

    Medical Office Space Available

    Medical office space with existing dental infrastructure for lease.

    36 N San Mateo Dr, San Mateo, CA
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    Based on your search, we've compiled 13 Potential Opportunities for your consideration. Besides 3 Active listings in San Mateo, CA, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 2 Properties for Sales.

    Medical Office Space for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Prime Corner Retail Opportunity
    $29,000 SF/Yr
    3,524 SF

    Prime Corner Retail Opportunity

    Highly visible retail space in downtown Burlingame with parking.

    1351 Howard Ave, Burlingame, CA 94010
    View details
    Downtown Medical/Office Space Available
    $3 SF/Yr
    1,734 SF

    Downtown Medical/Office Space Available

    Prime downtown location with treatment rooms and parking.

    961-963 Laurel Street, San Carlos, CA
    View details
    Class A Medical Office Space
    Contact for pricing
    4,897 SF

    Class A Medical Office Space

    Medical office space near Mills-Peninsula Medical Center and public transport.

    1720 El Camino Real, Burlingame, CA 94010
    View details
    San Carlos Biotech/Lab Space
    Contact for pricing
    13,500 SF

    San Carlos Biotech/Lab Space

    13,500 RSF biotech/lab/pharma/GMP manufacturing space available Spring 2026.

    San Carlos, CA 94070
    View details

    Similar Spaces for Sale in San Mateo, CA

    Consider Similar Space for Sale. We found 2 Spaces matching your search parameters.

    New Medical/Dental Condo For Sale
    $1,499,000
    4,000 SF
    New Medical/Dental Condo For Sale

    Newly constructed medical/dental condo on the San Mateo Burlingame border.

    420 Peninsula Avenue #3, San Mateo, CA 94401

    View details
    New Medical/Dental Condo For Sale
    $3,000,000
    4,000 SF
    New Medical/Dental Condo For Sale

    New medical/dental condo on San Mateo Burlingame border.

    420 Peninsula Avenue, San Mateo, CA 94401

    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Grand Junction Commercial Land Lease
    $9,656/Mo

    Grand Junction Commercial Land Lease

    0.74 acre commercial land for lease in Grand Junction.

    Highway 6&50, Grand Junction, CO 81505
    View details
    Grand Junction Commercial Land Opportunity
    $17,728/Mo

    Grand Junction Commercial Land Opportunity

    1.36 acre commercial land for lease in Grand Junction.

    Sanford Drive, Grand Junction, CO 81505
    View details
    El Paso Commercial Land Lease
    $3,600/Mo

    El Paso Commercial Land Lease

    Commercial land for lease in a strategic El Paso location.

    5538 E Paisano Drive, El Paso, TX 79905
    View details
    Office Development Land For Lease
    Contact for pricing
    4,000 SF

    Office Development Land For Lease

    2.43 acres for office development with build-to-suit opportunity.

    1323 Strawfloor Drive, Jonesboro, AR 72401
    View details

    San Mateo, CA Medical Office Space Leasing Opportunities Market Analysis

    Explore Medical Office Space leasing options in San Mateo, CA with 3 listings featured on our commercial real estate exchange. The current inventory includes 1,340 square feet of properties with an estimated lease value of $5 SF/Yr.

    Estimated lease rates for Medical Office Space in San Mateo, CA begin at $5 SF/Yr, with an average of $5 SF/Yr and extend to $5 SF/Yr.
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