Medical Premises

Santa Clarita, CA Medical Office Space for Sale

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Two-Story Medical Office Building
Updated: Jun 11
Two-Story Medical Office Building

22621 LYONS AVE, Santa Clarita, CA 91321

Contact for pricing
4,604 sqft
Freestanding two‑story medical office building built in 1992 with ground‑floor medical buildout and second‑floor executive suites
Two legal parcels on a large lot with dual ingress/egress from Lyons Avenue and Walnut Street
Second floor includes five executive suites for therapists or professional offices
Secured on‑site parking with above‑standard medical parking ratio and gated security
Upgraded HVAC control system and well‑maintained landscaping
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Based on your search, we've compiled 31 Potential Opportunities for your consideration. Besides 1 Active listings in Santa Clarita, CA, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 26 Off-Market properties to explore as potential leads

Opportunities in Nearby Cities

Here are 4 Similar properties we found in Nearby Locations for your consideration.

Medical Office with Dental Operatories
Medical Office with Dental Operatories

10727 White Oak Avenue, Los Angeles, CA 91344

Contact for pricing
2,200 sqft

Commercial medical zoning, healthcare equipment, and on-site parking support an established clinical office configuration.

View details
Single-Story Freestanding Medical Office
Single-Story Freestanding Medical Office

22151 Clarendon St, Woodland Hills, CA 91367

$1,199,000

Freestanding single-story building currently used for physical therapy with mixed-use zoning for a range of professional and service uses.

View details
Remodeled Office Building in Woodland Hills
Remodeled Office Building in Woodland Hills

19825 Ventura Boulevard, Woodland Hills, CA 91364

$1,995,000
3,462 sqft

Remodeled professional office building with prime location and ample parking.

View details
Dental Office with Three Operatories
Dental Office with Three Operatories

19458 Ventura Blvd, Los Angeles, CA 91356

Contact for pricing
1,200 sqft

Three-operatory dental office includes equipment and charts, located in a shopping center with signage and parking.

View details

Off-Market Properties in Santa Clarita, CA

Consider similar Off-Market properties in Santa Clarita, CA. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

22817 Lyons Ave
MEDICAL BUILDING

22817 Lyons Ave, Santa Clarita, CA 91321-2819

Estimated value:
$850,000
1,694 sqft 0.17 AC lot
View details
27335 Tourney Rd, Unit A-1
MEDICAL BUILDING

27335 Tourney Rd, Santa Clarita, CA 91355-2095

Unit A-1
Estimated value:
$1,010,000
1.18 AC lot
View details
17909 Soledad Cyn Rd
MEDICAL BUILDING

17909 Soledad Cyn Rd, Santa Clarita, CA 91387-3210

Estimated value:
$1,335,000
20,612 sqft 1.12 AC lot
View details
26877 Tourney Rd
MEDICAL BUILDING

26877 Tourney Rd, Santa Clarita, CA 91355-1846

Estimated value:
$10,190,000
118,157 sqft 4.12 AC lot
View details
27107 Tourney Rd
MEDICAL BUILDING

27107 Tourney Rd, Santa Clarita, CA 91355-1860

Estimated value:
$1,305,000
70,835 sqft 2.48 AC lot
View details
27335 Tourney Rd, Unit G2
MEDICAL BUILDING

27335 Tourney Rd, Santa Clarita, CA 91355-2095

Unit G2
Estimated value:
$1,055,000
1.18 AC lot
View details
27335 Tourney Rd, Unit J2
MEDICAL BUILDING

27335 Tourney Rd, Santa Clarita, CA 91355-2095

Unit J2
Estimated value:
$740,000
1.18 AC lot
View details
27335 Tourney Rd, Unit D2
MEDICAL BUILDING

27335 Tourney Rd, Santa Clarita, CA 91355-2095

Unit D2
Estimated value:
$1,465,000
1.18 AC lot
View details
27141 Hidaway Ave
MEDICAL BUILDING

27141 Hidaway Ave, Santa Clarita, CA 91351-4131

Estimated value:
$125,000
19,396 sqft 0.73 AC lot
View details
14550 Soledad Cyn Rd
MEDICAL BUILDING

14550 Soledad Cyn Rd, Santa Clarita, CA 91387-2200

Estimated value:
No data
38,308 sqft 0.85 AC lot
View details
14550 Soledad Cyn Rd
MEDICAL BUILDING

14550 Soledad Cyn Rd, Santa Clarita, CA 91387-2200

Estimated value:
No data
38,308 sqft 0.39 AC lot
View details
14550 Soledad Cyn Rd
MEDICAL BUILDING

14550 Soledad Cyn Rd, Santa Clarita, CA 91387-2200

Estimated value:
$20,265,000
38,308 sqft 2.04 AC lot
View details
23450 Lyons Ave Ste A
MEDICAL BUILDING

23450 Lyons Ave Ste A, Santa Clarita, CA 91321-5779

Estimated value:
$1,030,000
2,307 sqft 0.21 AC lot
View details
23928 Lyons Ave
MEDICAL BUILDING

23928 Lyons Ave, Santa Clarita, CA 91321-2409

Estimated value:
$3,250,000
21,680 sqft 0.17 AC lot
View details
22800 Lyons Ave
MEDICAL BUILDING

22800 Lyons Ave, Santa Clarita, CA 91321-6800

Estimated value:
$1,055,000
5,586 sqft 0.31 AC lot
View details
23929 Mcbean Pkwy
MEDICAL BUILDING

23929 Mcbean Pkwy, Santa Clarita, CA 91355-4466

Estimated value:
$19,835,000
83,698 sqft 8.94 AC lot
View details
23450 Lyons Ave Ste B
MEDICAL BUILDING

23450 Lyons Ave Ste B, Santa Clarita, CA 91321-5780

Estimated value:
$490,000
2,258 sqft 0.21 AC lot
View details
24515 Kansas St
MEDICAL BUILDING

24515 Kansas St, Santa Clarita, CA 91321-1719

Estimated value:
$330,000
2,877 sqft 0.29 AC lot
View details
22840 Soledad Cyn Rd
MEDICAL BUILDING

22840 Soledad Cyn Rd, Santa Clarita, CA 91350-2630

Estimated value:
$310,000
4,149 sqft 0.70 AC lot
View details
24318 Walnut St
MEDICAL BUILDING

24318 Walnut St, Santa Clarita, CA 91321-2924

Estimated value:
$290,000
4,697 sqft 0.15 AC lot
View details
23861 Mcbean Pkwy
Medical Office Space

23861 Mcbean Pkwy, Santa Clarita, CA 91355

Estimated value:
No data
46,054 sqft
View details
24120-24290 Valencia Blvd
Neighborhood centers

24120-24290 Valencia Blvd, Santa Clarita, CA 91355

Estimated value:
No data
172,856 sqft
View details
27940 Lost Canyon Rd
Medical Office Space

27940 Lost Canyon Rd, Santa Clarita, CA 91387

Estimated value:
No data
2,600 sqft
View details

Santa Clarita, CA Medical Office Space Market Trends and Statistics

Explore 27 medical office space for sale in Santa Clarita, CA on our real estate platform. These investment opportunities span a total of 4,604 square feet of properties for sale.

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Top Commercial Asset Segments

Commercial property segments ranked by active listings on the market

Office Units 30
Medical Office Space 9
Office buildings 4
Coworking space 2
Business parks 1

Demographics Overview

Population 286K
Population Growth (5Y) +1.7%
Median Household Income $124,373
College Educated 30.0%

High-Yield Neighborhoods for Investment

Identify Santa Clarita submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

Neighborhood Average Price
91350 $2.1M

Taxes & Financing

Tax Rate (average for all types) 1.46%
Property Tax per SF $34.46 per SF
Tax Rate vs County Average 0.19 pp above county avg
Average Loan-to-Value 65.0%

Listings Trend

New vs delisted commercial listings in Los Angeles County

New Delisted

Total CRE Inventory on Market (SF)

Average Property Price per SF

For-sale pricing trends across core commercial property types in Los Angeles County

Residential Income

Property Size Breakdown

The majority of commercial real estate listings in Santa Clarita fall within the 100,000+ square foot range.

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