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Two-Story Medical Office Building
For Sale
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22621 LYONS AVE, Santa Clarita, CA 91321

Freestanding two-story facility with a fully built-out medical ground floor and executive suites above, supported by secured parking.

Property Size4,604 SF
Days on Market59

Property Features for 22621 LYONS AVE

General Information

Standard status Active
Size 4,604 SF
Property subtype Office

Additional Details

Highway Access Yes
Office Units 5

Building Details

Year Built 1992
Stories 2
Listing Agency: Spectrum Commercial Real Estate, Inc
Listed By: Yair Haimoff · License #CA 01414758
Source: Crexi
Added: Jun 11 Changed: Jul 10 Last Checked: Aug 7 at 3:01AM

Displayed information is deemed reliable but is not guaranteed and should be independently verified. All listing content including descriptions, pricing, images are the copyrighted material of Spectrum Commercial Real Estate, Inc

Investment Insights

Based on property information with market context.

This freestanding, two-story Victorian-style medical office building sits on a large lot comprised of two legal parcels. The ground floor is fully built out for medical use with efficient layouts, while the second floor offers five executive suites suited to therapists and professional office users. The property also includes an upgraded HVAC control system, well-maintained landscaping, and prominent signage opportunities.

The building provides dual ingress and egress from Lyons Avenue and Walnut Street, supporting convenient access for staff and patients. Secured on-site parking and gated security are in place, along with above-standard medical parking based on the property’s stated parking ratio. It also features excellent street visibility and convenient proximity to a local library and Main Street Newhall amenities within walking distance, including dining, cafes, hotels, and entertainment venues such as Laemmle Newhall and The MAIN.

Offered for sale as a potential owner-user or investment, the property’s configuration supports an on-site medical practice on the first floor with additional professional space upstairs. Its proximity to Henry Mayo Newhall Hospital and major freeway access can help facilitate access for both patients and visiting professionals, and there is potential to add an elevator in the future.

Key Highlights

  • Freestanding two‑story medical office building built in 1992 with ground‑floor medical buildout and second‑floor executive suites
  • Two legal parcels on a large lot with dual ingress/egress from Lyons Avenue and Walnut Street
  • Second floor includes five executive suites for therapists or professional offices

Property Analytics

Current Use

Harter Karen MD Physician Umali Medical Clinic Medical Clinic Walter King Psychotherapy: ... Marriage Or Relationship Counselor Krista H Renella, ... Psychotherapist Rachelle R. Bodle, ... Marriage Or Relationship Counselor

Suggested Use

Top Pick Big Box & Wholesale Store Auto Parts Store Storage Facility Furniture & Home Goods Hotel & Motel Real Estate Agency

Score = modeled unmet demand for each use within ~1 mi (higher = bigger opportunity). Zoning and permitted uses should be independently verified with local authorities.

Lease Details

5
Office units
Yes
Highway access

Location Intelligence

Trade Area within ½ mile

1,798
Businesses Nearby
Balanced
Demand for This Use

Demographics for 91321, CA

33,560
Population
11,257
Households
3
Avg Household Size
37
Median Age
31%
College-Educated
84%
High-School Grad
26.7 sq mi
ZIP Area
1,257
Density / Sq Mi
$93,281
Median Household Income
$40,544
Median Earnings
$2,135
Median Rent
$654,300
Median Home Value

Market

Vacancy Rate% for Office in West region

11% 2019
14.1% 2020
15.5% 2021
17.2% 2022
19.9% 2023
21% 2024
20.8% 2025
Rey
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Frequently Asked Questions

What type of property is this?
Medical Office Space - Freestanding two-story facility with a fully built-out medical ground floor and executive suites above, supported by secured parking.
Where is this medical office space located?
The property is located at 22621 LYONS AVE Santa Clarita, CA.
What are key features of this property?
This property features: Freestanding two‑story medical office building built in 1992 with ground‑floor medical buildout and second‑floor executive suites; Two legal parcels on a large lot with dual ingress/egress from Lyons Avenue and Walnut Street; Second floor includes five executive suites for therapists or professional offices
(818) 203-5429 Call to check price and availability
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