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    Santa Clarita, CA Medical Office Space for Lease

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    Valencia, CA Stevenson Ranch, CA Castaic, CA
    9 results
    Santa Clarita Medical/Professional Office Space
    $2 SF/Yr
    10,436 SF

    Santa Clarita Medical/Professional Office Space

    23951 Newhall Ranch Road, Santa Clarita, CA 91355

    Newly renovated medical/professional office space available for lease.

    • Newly renovated interior with state‑of‑the‑art features.
    • Professional office space available.
    • Medical office space available.
    • Competitive lease rates.
    • 2nd floor location.
    Updated: Nov 22, 2025
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    Retail, Medical, and Office Park
    $16 SF/Yr

    Retail, Medical, and Office Park

    23548 Lyons Avenue, Santa Clarita, CA 91321

    Flexible leasing opportunities in a well-established Retail, Medical, and Office Park.

    • Prime location at the high‑traffic intersection of Lyons Avenue and Peachland in Newhall.
    • Flexible leasing opportunities for retail, medical, and office spaces.
    • Easy access to the I‑5 freeway.
    • Diverse tenant mix creating a dynamic business environment.
    • Ample parking available.
    Updated: Dec 10, 2024
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    Shared Medical Office in Santa Clarita
    Contact for pricing

    Shared Medical Office in Santa Clarita

    Shared medical office space in a prime Santa Clarita location.

    21060 Centre Pointe Pkwy, Santa Clarita, CA 91350
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    Medical Office Space Available
    $3 SF/Yr
    1,339 SF

    Medical Office Space Available

    Medical office space for rent in Santa Clarita.

    27875 Smyth Dr, Santa Clarita, CA
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    Advanced Medical Suites for Rent
    Contact for pricing

    Advanced Medical Suites for Rent

    Flexible, professional medical workspace with modern amenities in prime location.

    21050 Centre Pointe Pkwy, Santa Clarita, CA 91350
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    Medical Co-working Exam Rooms
    Contact for pricing
    78,000 SF

    Medical Co-working Exam Rooms

    Three exam rooms for lease in renovated medical building.

    26357 McBean Pkwy, Santa Clarita, CA 91355
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    Move-in Ready Second Floor Office
    Contact for pricing
    4,674 SF

    Move-in Ready Second Floor Office

    Second floor office space with medical build-out available for rent.

    24355 Lyons Ave, Santa Clarita, CA
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    Medical Building with Tenant Controlled Utilities
    $34 SF/Yr
    36,000 SF

    Medical Building with Tenant Controlled Utilities

    Two-story medical building featuring tenant-controlled utilities and 24-hour security.

    23501 Cinema Dr, Santa Clarita, CA 91355
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    Medical Office Building For Rent
    Contact for pricing

    Medical Office Building For Rent

    Three-story medical office building centrally located near major freeways.

    23838 Valencia Blvd, Santa Clarita, CA 91355
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    Based on your search, we've compiled 17 Potential Opportunities for your consideration. Besides 9 Active listings in Santa Clarita, CA, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities

    Medical Office Space for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Medical Office Space For Lease
    $3 SF/Yr
    8,175 SF

    Medical Office Space For Lease

    Prime medical office space available in a dedicated healthcare building.

    10515 Balboa Boulevard, Los Angeles, CA 91344
    View details
    Northridge Medical Office Space
    Contact for pricing
    1,120 SF

    Northridge Medical Office Space

    Ground-floor clinic space in Northridge, CA, near hospital.

    18251 Roscoe Boulevard, Northridge, CA 91325
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    Medical/Therapy Office Space Available
    $2 SF/Yr
    9,278 SF

    Medical/Therapy Office Space Available

    Medical/therapy office with multiple exam rooms and private restrooms.

    8349 Reseda Blvd |, Northridge, CA 91324
    View details
    Medical Office Building in Mission
    Contact for pricing
    7,000 SF

    Medical Office Building in Mission

    Three-story medical office building located in Mission Hills.

    11600 Indian Hills Road, Los Angeles, CA 91345
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Grand Junction Commercial Land Lease
    $9,656/Mo

    Grand Junction Commercial Land Lease

    0.74 acre commercial land for lease in Grand Junction.

    Highway 6&50, Grand Junction, CO 81505
    View details
    Grand Junction Commercial Land Opportunity
    $17,728/Mo

    Grand Junction Commercial Land Opportunity

    1.36 acre commercial land for lease in Grand Junction.

    Sanford Drive, Grand Junction, CO 81505
    View details
    El Paso Commercial Land Lease
    $3,600/Mo

    El Paso Commercial Land Lease

    Commercial land for lease in a strategic El Paso location.

    5538 E Paisano Drive, El Paso, TX 79905
    View details
    Office Development Land For Lease
    Contact for pricing
    4,000 SF

    Office Development Land For Lease

    2.43 acres for office development with build-to-suit opportunity.

    1323 Strawfloor Drive, Jonesboro, AR 72401
    View details

    Santa Clarita, CA Medical Office Space Leasing Opportunities Market Analysis

    Explore Medical Office Space leasing options in Santa Clarita, CA with 9 listings featured on our commercial real estate exchange. The current inventory includes 37,339 square feet of properties with an estimated lease value of $37 SF/Yr.

    Estimated lease rates for Medical Office Space in Santa Clarita, CA begin at $3 SF/Yr, with an average of $18 SF/Yr and extend to $34 SF/Yr.
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    Most Searched ZIP Codes in Santa Clarita, CA

    • 91355
    • 91350
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