Santa Clarita, CA Medical Office Space for Rent & Lease

Updated: Nov 22, 2025

Santa Clarita Medical/Professional Office Space

23951 Newhall Ranch Road, Santa Clarita, CA 91355

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10,436 sqft

Newly renovated interior with state‑of‑the‑art features.
Professional office space available.
Medical office space available.
Competitive lease rates.
2nd floor location.

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Updated: Jun 5, 2023

Medical Co-working Exam Rooms

26357 McBean Pkwy, Santa Clarita, CA 91355

$1,800/Mo

78,000 sqft

Cost‑effective daily rate of $150 per exam room.
Located in a renovated, Class A medical building.
Ample free parking for patients and staff.
High visibility corner building.
Close proximity to Henry Mayo Hospital with direct access to Rt 5.

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Medical Office Space Available

27875 Smyth Dr, Santa Clarita, CA

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1,339 sqft

Medical office space for rent in Santa Clarita.

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Move-in Ready Second Floor Office

24355 Lyons Ave, Santa Clarita, CA

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4,674 sqft

Second floor office space with medical build-out available for rent.

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Advanced Medical Suites for Rent

21050 Centre Pointe Pkwy, Santa Clarita, CA 91350

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Flexible, professional medical workspace with modern amenities in prime location.

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Medical Building with Tenant Controlled Utilities

23501 Cinema Dr, Santa Clarita, CA 91355

$34.20 SF/Yr

36,000 sqft

Two-story medical building featuring tenant-controlled utilities and 24-hour security.

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High-Image Office/Medical Building

26415 Carl Boyer Dr, Santa Clarita, CA 91350

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Two-story office/medical building in Centre Pointe Business Park.

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Medical Office Building For Rent

23838 Valencia Blvd, Santa Clarita, CA 91355

$30 SF/Yr

Three-story medical office building centrally located near major freeways.

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Based on your search, we've compiled 17 Potential Opportunities for your consideration. Besides 8 Active listings in Santa Clarita, CA, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 1 Properties for Sales.

Medical Office Space for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Ground-Floor Office Suite with Private Entry

5775 E Los Angeles Avenue, Simi Valley, CA 93063

$4,463/Mo

Move-in ready office suite with private exterior entrance, multiple private offices, and 24/7 security camera coverage.

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Medical-Ready Office Suite

5775 E Los Angeles Avenue, Simi Valley, CA 93063

Contact for pricing

Suite with built-out private office, tech/IT room, and exterior entrance for client-facing professional use.

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Medical Office Space For Lease

10515 Balboa Boulevard, Los Angeles, CA 91344

Contact for pricing

8,175 sqft

Prime medical office space available in a dedicated healthcare building.

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Medical Office Space Available

10515 Balboa Blvd, Los Angeles, CA 91344

$40.20 SF/Yr

8,175 sqft

8,175 SF medical office space in Doctors' Medical Plaza.

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Similar Spaces for Sale in Santa Clarita, CA

Consider Similar Space for Sale. We found 1 Spaces matching your search parameters.

Two-Story Medical Office Building

22621 LYONS AVE, Santa Clarita, CA 91321

Contact for pricing

4,604 sqft

Freestanding two-story facility with a fully built-out medical ground floor and executive suites above, supported by secured parking.

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Potential Development Sites for Consideration

Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

Commercial Land for Long-Term Lease

5538 E Paisano Drive, El Paso, TX 79905

$5,950/Mo

Lease a C4-zoned lot with easy interstate access, suited for a range of business and professional uses.

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Office Development Land For Lease

1323 Strawfloor Drive, Jonesboro, AR 72401

Contact for pricing

4,000 sqft

2.43 acres for office development with build-to-suit opportunity.

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Corner Lot on Highway 72

30472 Highway 72, Madison, AL 35756

$5,000/Mo

1,875 sqft

1.7 acre corner lot zoned for commercial, medical, residential.

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Prime Lexington Outlot Opportunity

3330 Partner Place, Lexington, KY 40503

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Outlot for ground lease or build-to-suit in South Lexington.

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Santa Clarita, CA Medical Office Space Market Trends and Statistics

Explore Medical Office Space leasing options in Santa Clarita, CA with 8 listings featured on our commercial real estate exchange. The current inventory includes 47,775 square feet of properties with an estimated lease value of $40.15 SF/Yr.

Estimated lease rates for Medical Office Space in Santa Clarita, CA begin at $2.95 SF/Yr, with an average of $13.38 SF/Yr and extend to $34.20 SF/Yr.