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    Picayune, MS Commercial Real Estate for Sale

    274 results
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    Versatile Commercial Property on Highway
    $650,000
    6,755 SF

    Versatile Commercial Property on Highway

    2467 Highway 43 South, Picayune, MS 39466

    6,755 sq ft commercial property on 1.32 acres.

    • High‑visibility location: Situated on Highway 43 South with 8,900+ vehicles passing daily.
    • Large commercial space: 6,755 sq. ft. on 1.32 acres provides ample room for various business ventures.
    • Versatile potential: Suitable for event venue, restaurant revival, short‑term rentals (Airbnb), or other commercial uses.
    • Strategic location: Only 5 minutes south of I‑59 in Picayune, offering easy access.
    • Rear quarters ideal for Airbnb or guest accommodations.
    Updated: Oct 29, 2025
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    Prime Commercial Building in Picayune
    $399,900
    3,915 SF

    Prime Commercial Building in Picayune

    707 Memorial Blvd, Picayune, MS 39466

    Spacious commercial building with multiple suites in prime location.

    • Prime location in Picayune offering high visibility and accessibility.
    • Excellent investment opportunity for new or established businesses.
    • Located right off I‑59 and surrounded by other businesses.
    • Four possible rental suites in one building.
    • Three suites include bathrooms and kitchens.
    Updated: Dec 1, 2025
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    Profitable Cinema on High-Traffic Location
    $1,150,000
    10,800 SF

    Profitable Cinema on High-Traffic Location

    10,800 sq. ft. cinema on 1.9 acres near I-59.

    997 Cooper Rd, Picayune, MS 39466
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    Turnkey Auto Repair Business
    $325,000
    4,912 SF

    Turnkey Auto Repair Business

    Established auto repair business on 1.82 acres.

    1747 Highway 11 South, Picayune, MS 39466
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    Picayune Commercial Building For Sale
    $450,000
    3,064 SF

    Picayune Commercial Building For Sale

    3,010 sq ft building on 1.02 acres near I-59.

    2508 Highway 43 S, Picayune, MS 39466
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    Commercial Space with Roll-Up Doors
    $280,000
    7,250 SF

    Commercial Space with Roll-Up Doors

    Commercial space with roll-up doors, ideal for various businesses.

    105 S Columbia St, Picayune, MS 39466
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    7,500 SF Warehouse on 2 Acres
    $269,000
    7,500 SF

    7,500 SF Warehouse on 2 Acres

    Warehouse on 2 acres with office space for sale.

    1817 Palestine Rd, Picayune, MS 39466
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    Picayune Church Property for Sale
    $499,000
    4,410 SF

    Picayune Church Property for Sale

    Community church with sanctuary, meeting rooms, and ample parking.

    1700 Goodyear Blvd, Picayune, MS 39466
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    Commercial Property on 3.4 Acres
    $640,000
    21,350 SF

    Commercial Property on 3.4 Acres

    Three buildings on 3.4 acres, suitable for various commercial uses.

    1007 Highway 11 South, Picayune, MS 39466
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    Picayune Commercial Retail Space Available
    $245,000
    10,000 SF

    Picayune Commercial Retail Space Available

    Retail property with highway access in Picayune, Mississippi.

    213 Highway 11 South, Picayune, MS 39466
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    Picayune Commercial Building For Sale
    $379,000
    2,300 SF

    Picayune Commercial Building For Sale

    Versatile commercial building with drive-thru, excellent visibility, and ample parking.

    249 Frontage Rd, Picayune, MS 39466
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    Retail Space Near Walmart
    Contact for pricing
    1,500 SF

    Retail Space Near Walmart

    Commercial retail space available, 1500 sq ft, near Hwy 43.

    1407 Armand Dr, Picayune, MS 39466
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    Restaurant Ready Commercial Property
    $149,500
    1,727 SF

    Restaurant Ready Commercial Property

    Commercial property with restaurant equipment included, ready for operation.

    728 West Canal St, Picayune, MS 39466
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    Commercial Land on Highway 11
    $765,784
    8.79 Acres

    Commercial Land on Highway 11

    Undeveloped commercial land with highway frontage in a growing area.

    6499 Highway 11 North, Picayune, MS 39466
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    Prime Highway 11 Vacant Lot
    $784,080
    2.09 Acres

    Prime Highway 11 Vacant Lot

    Ideally located commercial land on Highway 11 in Picayune.

    00 Highway 11 North, Picayune, MS 39466
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    Picayune Commercial Property For Sale
    $385,000
    6,750 SF

    Picayune Commercial Property For Sale

    Multipurpose commercial property with potential for various uses.

    502 Jarrell St, Picayune, MS 39466
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    Cleared Land on Highway 43
    $199,900
    13.75 Acres

    Cleared Land on Highway 43

    13.75-acre tract zoned A-1 with road frontage, ready for development.

    19910 Highway 43, Picayune, MS 39466
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    Remodeled Commercial Property with High Visibility
    $315,000
    952 SF

    Remodeled Commercial Property with High Visibility

    Remodeled commercial property with high visibility and many added features.

    1307 Hwy. 11 South, Picayune, MS 39466
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    Picayune Commercial Land For Sale
    $1,098,000
    5.78 Acres

    Picayune Commercial Land For Sale

    5.78 acre commercial land in Picayune, Mississippi.

    00 Highland Pkwy, Picayune, MS 39466
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    High Visibility Commercial Lot For Sale
    $549,000
    1.04 Acres

    High Visibility Commercial Lot For Sale

    Commercial lot for sale or lease in high-traffic location.

    105 Highland Pkwy, Picayune, MS 39466
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    High Visibility Commercial Lot For Sale
    $549,000
    1.04 Acres

    High Visibility Commercial Lot For Sale

    Commercial lot near hospital with high traffic and multiple opportunities.

    105 Highland Pkwy, Picayune, MS 39466
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    High Visibility Commercial Lot
    $549,000
    1.04 Acres

    High Visibility Commercial Lot

    Commercial lot near hospital and post office, zoned C3.

    105 Highland Pkwy, Picayune, MS 39466
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    Picayune, MS Wooded Land
    $405,000
    45.00 Acres

    Picayune, MS Wooded Land

    45 acres of wooded land with highway frontage.

    S Leetown And Hwy 43, Picayune, MS 39466
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    Picayune Land with Mixed Zoning
    $295,000
    5.40 Acres

    Picayune Land with Mixed Zoning

    5.4 acre property zoned for commercial, multi-family, or single-family use.

    00 Elm St, Picayune, MS 39466
    View details

    Picayune, MS Commercial Real Estate Investment Opportunities Market Analysis

    Explore 64 commercial real estate for sale in Picayune, MS, showcased through 274 active listings on our real estate platform. These investment opportunities span a total of 10,315,139 square feet of properties for sale, with an estimated market value of $20,251,224.

    Sale prices for business properties in Picayune, MS start at $38,500, averaging $368,204, and reaching up to $1,150,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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