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    St Francois County, MO Commercial Real Estate for Sale

    117 results
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    De Soto Church Building on 5+ Acres
    $399,900
    3,739 SF

    De Soto Church Building on 5+ Acres

    4041 Maple Downs Ct, De Soto, MO 63020

    Church building with spacious sanctuary and high-visibility location.

    • Spacious 5+/- acre property with high visibility location.
    • Large sanctuary with high ceilings and ample natural light, seating for approximately 140.
    • Newer construction (built in 2007) and in move‑in ready condition.
    • Large paved parking area with 40+ spaces and room for expansion.
    • Zoned HVAC systems for efficient climate control.
    Updated: Mar 9
    View details
    Established Tire Business with Real Estate
    $115,000
    2,541 SF

    Established Tire Business with Real Estate

    112 W Kelley St, De Soto, MO 63020

    Operating used tire business with real estate in De Soto.

    • Established used tire business with real estate included, offering immediate business opportunity.
    • Commercial building featuring a customer area, office, bathroom, and convenient 4‑bay lean‑to.
    • Includes business equipment, inventory, and tire stock (quantity subject to change).
    • Potential for continued business growth and real estate value appreciation.
    • 1920 two‑story house with rehab potential for rental income or business use.
    Updated: Mar 5
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    Farmington Mixed-Use Commercial Property
    $299,900
    3,008 SF

    Farmington Mixed-Use Commercial Property

    2574 SF mixed-use property with detached garage and ample parking.

    210 Hyler Dr, Farmington, MO 63640
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    Bonne Terre Church For Sale
    $495,000
    7,680 SF

    Bonne Terre Church For Sale

    7680 sq ft church building on 1.29 acres.

    530 Benham St, Bonne Terre, MO 63628
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    Versatile Commercial Property on Highway
    $1,399,000
    15,000 SF

    Versatile Commercial Property on Highway

    Commercial property with high visibility and multiple income streams.

    3350 Highway O, Park Hills, MO 63601
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    Former Drive-Thru Liquor Store
    $170,000
    964 SF

    Former Drive-Thru Liquor Store

    High-visibility location in Bonne Terre, Missouri.

    24 W School St, Bonne Terre, MO 63628
    View details
    Historic Mixed-Use Commercial Property
    $219,000
    4,095 SF

    Historic Mixed-Use Commercial Property

    Unique 4,095 SF commercial property in downtown De Soto.

    400 N 3Rd St, De Soto, MO 63020
    View details
    Highway 21 Commercial Opportunity
    $419,000
    4.05 Acres

    Highway 21 Commercial Opportunity

    7,788 sq. ft. building on 4 acres in De Soto.

    13326 Rte 21, De Soto, MO 63020
    View details
    Turnkey Restaurant/Bar in Park Hills
    $224,900
    0.21 Acres

    Turnkey Restaurant/Bar in Park Hills

    Established restaurant/bar with updated interior and outdoor seating.

    201 Houser St, Park Hills, MO 63601
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    Park Hills Commercial Building For Sale
    $250,000
    2,055 SF

    Park Hills Commercial Building For Sale

    High-traffic commercial building suitable for retail, office, or investment.

    120 W Main St, Park Hills, MO 63601
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    Bismarck Ranch with Open Pasture
    $459,900
    3,056 SF

    Bismarck Ranch with Open Pasture

    Ranch home on 30 acres with pond and barn.

    10399 Gibson Rd, Bismarck, MO 63624
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    De Soto Retail Business Opportunity
    $850,000
    15,500 SF

    De Soto Retail Business Opportunity

    Own a business and a piece of history!

    400 S Main St, De Soto, MO 63020
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    Commercial Lot in Terre Du Lac
    $42,500
    0.33 Acres

    Commercial Lot in Terre Du Lac

    Highly visible commercial lot ready for development in Bonne Terre.

    St Francois Rd, Bonne Terre, MO 63628
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    Secluded Farm with Pool and Shop
    $620,000
    4,598 SF

    Secluded Farm with Pool and Shop

    10-acre farm with home, pool, shop, and cabin.

    960 Rdg Top Dr, Farmington, MO 63640
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    Spacious Ranch with Modern Comforts
    $950,000
    2,698 SF

    Spacious Ranch with Modern Comforts

    Custom-built home on 33 acres, ideal for country living.

    3700 State Road V, De Soto, MO 63020
    View details
    68 Acres Near Highway Frontage
    $646,000
    67.94 Acres

    68 Acres Near Highway Frontage

    68 acre farm with highway frontage near schools and shopping.

    State Route 21, De Soto, MO 63020
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    High Visibility Garage in Bonne Terre
    $244,900
    0.23 Acres

    High Visibility Garage in Bonne Terre

    Four-bay garage suitable for automotive or retail use.

    112 Division St, Bonne Terre, MO 63628
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    Prime Land Near Shopping Center
    $699,900
    1.59 Acres

    Prime Land Near Shopping Center

    Unimproved land with high traffic and road frontage.

    772 Weber Rd, Farmington, MO 63640
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    Farmington Land: Dual-Use Opportunity
    $50,000
    4.42 Acres

    Farmington Land: Dual-Use Opportunity

    4.42-acre parcel suitable for mixed-use development in Farmington, MO.

    800 E Woodlawn Dr, Farmington, MO 63640
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    Downtown Farmington Multi-Tenant Office Building
    $1,350,000
    32,376 SF

    Downtown Farmington Multi-Tenant Office Building

    Value-add opportunity with vacant suites and flexible tenancy.

    400 N Washington St, Farmington, MO 63640
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    Remodeled Mixed-Use Property in De Soto
    $164,000
    0.16 Acres

    Remodeled Mixed-Use Property in De Soto

    Remodeled 2-bedroom home with commercial zoning in De Soto, MO.

    401 E Miller St, De Soto, MO 63020
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    68 Acres Near Highway Frontage
    $646,000
    67.94 Acres

    68 Acres Near Highway Frontage

    68 acres near school, shopping, and highway frontage.

    State Route 21, De Soto, MO 63020
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    Lakeview Cabins in Gated Community
    $52,500
    0.21 Acres

    Lakeview Cabins in Gated Community

    Two cabins on a single lot in a gated community.

    9279 Beach Dr, French Village, MO 63036
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    Farm Property with Highway Frontage
    $1,680,000
    1,652 SF

    Farm Property with Highway Frontage

    16+ acre farm with commercial potential near Hwy 67.

    1741 Liberty St, Farmington, MO 63640
    View details

    St Francois County, MO Commercial Real Estate Investment Opportunities Market Analysis

    Explore 64 commercial real estate for sale in St Francois County, MO, showcased through 117 active listings on our real estate platform. These investment opportunities span a total of 34,157,552 square feet of properties for sale, with an estimated market value of $24,613,698.

    Sale prices for business properties in St Francois County, MO start at $35,000, averaging $535,080, and reaching up to $2,900,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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