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    Mississippi County, MO Commercial Real Estate for Sale

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    Kansas City, MO Louis, MO Saint Louis, MO
    12 listings
    East Prairie Commercial Building For Sale
    $185,000
    9,700 SF
    East Prairie Commercial Building For Sale

    201-203 E. Pine, East Prairie, MO 63845

    9700 sqft commercial building in East Prairie, Missouri.
    • Priced below last appraised value
    • Excellent location close to downtown East Prairie
    • 9700 square foot building suitable for retail or office use
    • 8‑10 overhead doors for deliveries or loading
    • Ample parking for approximately 20 cars
    Updated: Dec 15, 2025
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    Remodeled Commercial Property in Charleston
    $350,000
    4,173 SF
    Remodeled Commercial Property in Charleston

    506 S Main Street, Charleston, MO 63834

    Turnkey commercial property with residential zoning in prime location.
    • Prime location with high visibility.
    • Turnkey, beautifully remodeled commercial property.
    • Zoned for commercial/residential use.
    • Substantial 4173 Sq Ft of space.
    • New roof, windows, flooring, and bathrooms.
    Updated: Jan 23
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    Productive Farmland Investment Opportunity
    $918,000
    101.94 Acres
    Productive Farmland Investment Opportunity

    101.94 acres of farmland in Mississippi and New Madrid Counties.

    0 S Highway BB, East Prairie, MO 63845

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    Charleston, MO Commercial Land Opportunity
    $950,000
    11.04 Acres
    Charleston, MO Commercial Land Opportunity

    11.04 acre commercial land with high visibility and access.

    3,5,7,9 Charleston Plaza, Charleston, MO 63834

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    Productive Farm in Bertrand, Missouri
    $1,100,000
    230.00 Acres
    Productive Farm in Bertrand, Missouri

    230-acre farm with income potential and expansion opportunities.

    000 County Road 429, Bertrand, MO 63823

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    Remodeled Mixed-Use Property For Sale
    $425,000
    4,173 SF
    Remodeled Mixed-Use Property For Sale

    Turnkey, remodeled mixed-use property with commercial/residential zoning.

    506 S Main Street, Charleston, MO 63834

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    RV Park with Restaurant
    $740,000
    3,876 SF
    RV Park with Restaurant

    RV park with restaurant, store, cabins, and highway frontage.

    4067 W. 404 Road, Bertrand, MO 63823

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    Charleston, MO Commercial Investment Opportunity
    $575,000
    2,134 SF
    Charleston, MO Commercial Investment Opportunity

    High-traffic commercial property suitable for restaurant, retail, or office use.

    11 Truman St, Charleston, MO 63834

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    Farmland in Desirable Farming Area
    $655,000
    66.23 Acres
    Farmland in Desirable Farming Area

    66.23 acres of farmland perfect for agricultural use.

    Hwy 60, Wyatt, MO 63882

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    17-Acre Parcel Near Dogwood Community
    $260,000
    17.00 Acres
    17-Acre Parcel Near Dogwood Community

    17-acre parcel with tillable land and rental properties.

    2447 West 416th Road, East Prairie, MO 63845

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    Retail Building on Highway 105
    $84,000
    1,452 SF
    Retail Building on Highway 105

    Retail building with great visibility and expansion potential.

    2380 S. Main, Charleston, MO 63834

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    High-Frontage Retail or Office Building
    $99,900
    2,121 SF
    High-Frontage Retail or Office Building

    Commercial building on a highway-frontage site with space for retail or office redevelopment.

    1113 E. Marshall, Charleston, MO 63834

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    Based on your search, we've compiled 72 Potential Opportunities for your consideration. Besides 12 Active listings in Mississippi County, MO, we suggest exploring several alternatives: similar 60 Off-Market properties to explore as potential leads

    Off-Market Properties in Mississippi County, MO

    Consider similar Off-Market properties in Mississippi County, MO. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    102 Garfield St
    COMMERCIAL (GENERAL)
    Lot: 0.88 Acres
    Value Estimation by Request

    102 Garfield St, East Prairie, MO 63845-1556

    View details
    115 Main St
    OFFICE (GENERAL)
    4,453 SF Lot: 0.39 Acres
    Value Estimation by Request

    115 Main St, Charleston, MO 63834-1632

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    203 Washington St
    RETAIL STORES (PERSONAL SERVICES)
    2,173 SF Lot: 0.40 Acres
    Value Estimation by Request

    203 Washington St, East Prairie, MO 63845-1527

    View details
    Aly Behind 606th Helena
    WAREHOUSE, STORAGE
    1,571 SF Lot: 0.10 Acres
    Value Estimation by Request

    Aly Behind 606th Helena, Charleston, MO 63834

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    801 Marshall St
    OFFICE (GENERAL)
    7,032 SF Lot: 0.33 Acres
    Value Estimation by Request

    801 Marshall St, Charleston, MO 63834-1262

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    204 1st St
    OFFICE (GENERAL)
    1,664 SF Lot: 0.10 Acres
    Value Estimation by Request

    204 1st St, Charleston, MO 63834-1100

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    105 Ctr St
    RETAIL STORES (PERSONAL SERVICES)
    1,612 SF Lot: 0.04 Acres
    Value Estimation by Request

    105 Ctr St, Charleston, MO 63834-1602

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    208 Commercial St
    OFFICE (GENERAL)
    2,150 SF Lot: 0.16 Acres
    Value Estimation by Request

    208 Commercial St, Charleston, MO 63834-1749

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    Garfield
    CAR WASH
    2,478 SF Lot: 0.34 Acres
    Value Estimation by Request

    Garfield, East Prairie, MO 63845

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    201 Ctr St
    FUNERAL HOME
    5,588 SF Lot: 0.63 Acres
    Value Estimation by Request

    201 Ctr St, Charleston, MO 63834-1604

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    931 Main St
    SERVICE STATION (FULL SERVICE)
    1,305 SF Lot: 0.27 Acres
    Value Estimation by Request

    931 Main St, East Prairie, MO 63845-8133

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    121 Pne St
    RETAIL STORES (PERSONAL SERVICES)
    1,686 SF Lot: 0.20 Acres
    Value Estimation by Request

    121 Pne St, East Prairie, MO 63845-1137

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    Mississippi County, MO Commercial Real Estate Investment Opportunities Market Analysis

    Explore 72 commercial real estate for sale in Mississippi County, MO, showcased through 12 active listings on our real estate platform. These investment opportunities span a total of 27,629 square feet of properties for sale, with an estimated market value of $2,458,900.

    Sale prices for business properties in Mississippi County, MO start at $84,000, averaging $351,271, and reaching up to $740,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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