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    New Madrid County, MO Commercial Real Estate for Sale

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    Saint Louis, MO Kansas City, MO Louis, MO
    Highway-Accessible Manufacturing/Warehouse Facility
    $1,300,000
    17,370 SF

    Highway-Accessible Manufacturing/Warehouse Facility

    2946 State Highway V, Matthews, MO 63867

    Versatile industrial property with office, warehouse, and manufacturing space.

    • Strategic location with high visibility and immediate access to Interstate 55
    • Large 2.93‑acre site suitable for various purposes
    • Substantial 16,218 SF warehouse/manufacturing space with high ceilings and overhead doors
    • Includes a 792 SF office building
    • Turnkey property, currently set up for manufacturing, with equipment included in the sale
    Updated: Aug 6, 2025
    View details
    I-55 Land Parcel Opportunity
    $395,000

    I-55 Land Parcel Opportunity

    337 State Highway P, New Madrid, MO 63869

    5 acre parcel suitable for truck stop or fuel station.

    • Prime location on the northwest corner of southbound I‑55 at mile marker 52.
    • 5‑acre parcel suitable for a truck stop or fuel station.
    • All utilities are available at the site.
    • Opportunity for a secluded truck stop location with less competition.
    • Previously a fuel station.
    Updated: Mar 5
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    I-55 Frontage Development Opportunity
    $395,000

    I-55 Frontage Development Opportunity

    5 acre commercial land parcel with I-55 frontage.

    337 State Hwy P, New Madrid, MO 63869
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    Commercial Building in Portageville, MO
    $225,000
    2,379 SF

    Commercial Building in Portageville, MO

    Versatile commercial building suitable for various business types.

    205 E. 4th St, Portageville, MO 63873
    View details
    Based on your search, we've compiled 905 Potential Opportunities for your consideration. Besides 4 Active listings in New Madrid County, MO, we suggest exploring several alternatives: similar 901 Off-Market properties to explore as potential leads

    Explore Off-Market Properties in New Madrid County, MO

    Consider similar Off-Market properties in New Madrid County, MO. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    Us Hwy 61

    Us Hwy 61

    COMMERCIAL (GENERAL) • 0.50 Acres
    Value Estimation by Request
    Us Hwy 61, New Madrid, MO 63869
    View details
    1320 Main St

    1320 Main St

    COMMERCIAL (GENERAL) • 1.80 Acres
    Value Estimation by Request
    1320 Main St, Sikeston, MO 63801-9359
    View details
    Us Hwy 61

    Us Hwy 61

    COMMERCIAL (GENERAL) • 1,448 SF
    Value Estimation by Request
    Us Hwy 61, Portageville, MO 63873
    View details
    704 Us Hwy 61

    704 Us Hwy 61

    COMMERCIAL (GENERAL) • 2,069 SF
    Value Estimation by Request
    704 Us Hwy 61, New Madrid, MO 63869-1123
    View details
    1057 Main St

    1057 Main St

    COMMERCIAL (GENERAL) • 1.27 Acres
    Value Estimation by Request
    1057 Main St, Sikeston, MO 63801-3135
    View details
    110 St Frnt Frnt

    110 St Frnt Frnt

    COMMERCIAL (GENERAL)
    Value Estimation by Request
    110 St Frnt Frnt, Morehouse, MO 63868
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    3143 State Hwy Ff

    3143 State Hwy Ff

    COMMERCIAL (GENERAL) • 1.20 Acres
    Value Estimation by Request
    3143 State Hwy Ff, Sikeston, MO 63801
    View details
    801 Plantation Blvd

    801 Plantation Blvd

    COMMERCIAL (GENERAL)
    Value Estimation by Request
    801 Plantation Blvd, Sikeston, MO 63801-5744
    View details
    Us Hwy 61

    Us Hwy 61

    COMMERCIAL (GENERAL) • 6,000 SF
    Value Estimation by Request
    Us Hwy 61, Portageville, MO 63873
    View details
    209 Main St

    209 Main St

    COMMERCIAL (GENERAL) • 2,000 SF
    Value Estimation by Request
    209 Main St, Portageville, MO 63873-1613
    View details
    Main St

    Main St

    VACANT COMMERCIAL LAND
    Value Estimation by Request
    Main St, New Madrid, MO 63869
    View details
    1003 State Hwy Aa

    1003 State Hwy Aa

    COMMERCIAL (GENERAL) • 4,800 SF
    Value Estimation by Request
    1003 State Hwy Aa, Matthews, MO 63867-9135
    View details
    Main St

    Main St

    COMMERCIAL (GENERAL) • 420 SF
    Value Estimation by Request
    Main St, New Madrid, MO 63869
    View details
    93 Sisson St

    93 Sisson St

    COMMERCIAL (GENERAL) • 3,466 SF
    Value Estimation by Request
    93 Sisson St, New Madrid, MO 63869-9185
    View details
    501 Outer Rd

    501 Outer Rd

    COMMERCIAL (GENERAL) • 12,884 SF
    Value Estimation by Request
    501 Outer Rd, Marston, MO 63866
    View details
    104 Acres St

    104 Acres St

    COMMERCIAL (GENERAL) • 3,059 SF
    Value Estimation by Request
    104 Acres St, Sikeston, MO 63801-5606
    View details
    515 Virginia Ave

    515 Virginia Ave

    COMMERCIAL (GENERAL)
    Value Estimation by Request
    515 Virginia Ave, New Madrid, MO 63869
    View details
    3rd St At King Ave

    3rd St At King Ave

    COMMERCIAL (GENERAL) • 1,830 SF
    Value Estimation by Request
    3rd St At King Ave, Portageville, MO 63873
    View details
    106 Main St

    106 Main St

    COMMERCIAL (GENERAL) • 1,144 SF
    Value Estimation by Request
    106 Main St, Matthews, MO 63867
    View details
    413 Main St

    413 Main St

    COMMERCIAL (GENERAL) • 2,100 SF
    Value Estimation by Request
    413 Main St, Portageville, MO 63873-1617
    View details

    New Madrid County, MO Commercial Real Estate Investment Opportunities Market Analysis

    Explore 905 commercial real estate for sale in New Madrid County, MO, showcased through 4 active listings on our real estate platform. These investment opportunities span a total of 19,749 square feet of properties for sale, with an estimated market value of $1,525,000.

    Sale prices for business properties in New Madrid County, MO start at $225,000, averaging $762,500, and reaching up to $1,300,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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